ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

SNP Report

Basic Info

Name	rs1801260 dbSNP Ensembl
Location	Chr4:56301369(Fwd)
Variant Alleles	A/G
Ancestral Allele	A
Functional Annotation	3_prime_UTR_variant; nc_transcript_variant; non_coding_exon_variant.
Consequence to Transcript	3_prime_UTR_variant(ENST00000381322; ENST00000309964; ENST00000513440) nc_transcript_variant(ENST00000511124) non_coding_exon_variant(ENST00000511124)
No. of Studies	2 (significant: 2; non-significant: 0; trend: 0)
Source	Literature-origin

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Kissling C, 2008	T/C		P-value<0.001 P-value<0.001	a strong, significant association between each of the adult ...... a strong, significant association between each of the adult ADHD assessments and the rs1801260 polymorphism More...	Significant
Xu X, 2010	T:C		TDT P-value=0.146, X² (1df)=2.110 for UK samples ...... TDT P-value=0.146, X² (1df)=2.110 for UK samples allele; TDT P-value=0.010, X² (1df)=6.701 for Taiwanese samples allele; TDT P-value=0.008, X² (1df)=7.136 for combined samples allele More...	increased transmission of the T allele in the Taiwanese samp...... increased transmission of the T allele in the Taiwanese samples and combined samples; no significant association in the UK sample More...	Significant

SNP related genes (count: 1)

Literature-origin genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
CLOCK	clock homolog (mouse)	4q12	2(2/0/0)

Genes from other sources (count: 0)

SNPs in LD with rs1801260 (count: 65) View in gBrowse (chr4:56235592..56482750 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

Literature-origin SNPs (count: 0)

LD-proxies (count: 65)

rs_ID	Functional Annotation	r²[population]
rs13133077	intron_variant	0.857[CEU]; 0.926[YRI]
rs2070062	5_prime_UTR_variant; NMD_transcript_variant; nc_transcript_variant; non_coding_exon_variant	1.0[CEU]; 1.0[CHB]; 1.0[JPT]; 1.0[YRI]
rs476184	downstream_gene_variant; intron_variant; nc_transcript_variant	1.0[ASW]; 1.0[CHB]; 0.911[CHD]; 1.0[JPT]; 0.83[TSI]
rs1021307	NMD_transcript_variant; intron_variant; nc_transcript_variant	1.0[ASW]; 1.0[CEU]; 1.0[CHB]; 1.0[CHD]; 1.0[GIH]; 1.0[JPT]; 0.872[LWK]; 1.0[MEX]; 1.0[MKK]; 1.0[TSI]; 1.0[YRI]
rs819268	intron_variant; nc_transcript_variant	0.812[JPT]
rs11240	downstream_gene_variant; intron_variant; upstream_gene_variant	1.0[CEU]; 1.0[CHB]; 1.0[JPT]; 1.0[YRI]
rs1873091	intron_variant; nc_transcript_variant	1.0[CHB]; 0.917[CHD]; 0.93[JPT]
rs10000512	intron_variant; nc_transcript_variant	1.0[CHB]; 0.923[JPT]
rs10018932	intron_variant; nc_transcript_variant	1.0[CHB]; 0.927[JPT]
rs1048004	3_prime_UTR_variant; downstream_gene_variant; nc_transcript_variant; non_coding_exon_variant	1.0[ASW]; 0.846[CHD]; 1.0[GIH]; 0.803[JPT]; 0.958[LWK]; 0.982[MKK]; 0.92[TSI]
rs17725163	intron_variant; nc_transcript_variant	1.0[CHB]; 0.917[CHD]; 0.856[JPT]
rs11932595	intron_variant; nc_transcript_variant	1.0[CHB]; 0.846[CHD]; 0.93[JPT]
rs3792603	intron_variant; nc_transcript_variant	1.0[CHB]; 1.0[CHD]; 1.0[JPT]
rs11732481	intron_variant	1.0[CEU]; 1.0[CHB]; 0.923[JPT]; 0.923[YRI]
rs1021306	NMD_transcript_variant; intron_variant; nc_transcript_variant	1.0[CEU]; 1.0[CHB]; 1.0[JPT]; 1.0[YRI]
rs9993599	intron_variant	1.0[CEU]; 1.0[CHB]; 0.867[JPT]; 0.927[YRI]
rs7665846	intron_variant	1.0[CEU]; 0.816[JPT]; 0.837[YRI]
rs576732	3_prime_UTR_variant; downstream_gene_variant; intron_variant; nc_transcript_variant	0.823[CHD]; 0.812[JPT]; 0.835[TSI]
rs9996936	intron_variant; nc_transcript_variant	1.0[CHB]; 0.93[JPT]
rs10012559	intron_variant	1.0[CEU]; 1.0[CHB]; 0.804[YRI]
rs1979605	downstream_gene_variant	1.0[CEU]; 1.0[CHB]; 1.0[JPT]; 0.88[YRI]
rs4336288	intron_variant	1.0[CEU]; 1.0[CHB]; 0.868[JPT]; 0.931[YRI]
rs2412664	downstream_gene_variant; intron_variant	0.885[ASW]; 1.0[CHB]; 0.917[CHD]; 0.868[JPT]; 0.947[MKK]; 0.87[YRI]
rs2538	3_prime_UTR_variant; downstream_gene_variant; intron_variant; nc_transcript_variant	0.812[JPT]
rs6554290	intron_variant	0.885[ASW]; 0.906[CEU]; 1.0[CHB]; 0.846[CHD]; 0.889[GIH]; 0.866[JPT]; 0.867[LWK]; 0.963[MKK]; 0.945[TSI]; 0.934[YRI]
rs6802	3_prime_UTR_variant; downstream_gene_variant	1.0[CEU]; 1.0[CHB]; 1.0[JPT]
rs3805389	intron_variant; nc_transcript_variant	1.0[CHB]; 0.917[CHD]; 0.856[JPT]
rs4865012	downstream_gene_variant	1.0[CEU]; 1.0[CHB]; 1.0[JPT]; 1.0[YRI]
rs17722979	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	1.0[ASW]; 1.0[CEU]; 1.0[CHB]; 1.0[CHD]; 0.977[GIH]; 0.93[JPT]; 0.872[LWK]; 1.0[MKK]; 1.0[TSI]; 1.0[YRI]
rs7660668	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant	1.0[CEU]; 1.0[CHB]; 1.0[JPT]; 1.0[YRI]
rs552792	downstream_gene_variant; intron_variant; nc_transcript_variant	1.0[CHB]; 0.911[CHD]; 1.0[JPT]; 0.81[TSI]
rs819270	3_prime_UTR_variant; downstream_gene_variant; intron_variant; nc_transcript_variant	0.812[JPT]
rs10011801	intron_variant; nc_transcript_variant	1.0[CHB]; 0.927[JPT]
rs880358	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	1.0[CEU]; 1.0[CHB]; 1.0[CHD]; 1.0[GIH]; 1.0[JPT]; 1.0[MEX]; 1.0[TSI]
rs483978	intron_variant; nc_transcript_variant; upstream_gene_variant	1.0[ASW]; 1.0[CHB]; 0.911[CHD]; 0.808[GIH]; 1.0[JPT]; 0.812[MEX]; 0.92[TSI]; 0.871[YRI]
rs6554291	intron_variant	0.885[ASW]; 1.0[CEU]; 1.0[CHB]; 0.917[CHD]; 1.0[GIH]; 0.868[JPT]; 0.872[LWK]; 0.948[MEX]; 0.982[MKK]; 0.972[TSI]; 0.934[YRI]
rs10026676	intron_variant; nc_transcript_variant	1.0[CHB]; 0.856[JPT]
rs11732723	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant	0.814[GIH]; 1.0[JPT]
rs13434995	intron_variant; nc_transcript_variant	1.0[CHB]; 0.917[CHD]; 0.868[JPT]
rs550144	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant; upstream_gene_variant	1.0[ASW]; 1.0[CEU]; 1.0[CHB]; 1.0[CHD]; 1.0[GIH]; 1.0[JPT]; 0.919[LWK]; 1.0[MEX]; 0.898[MKK]; 1.0[TSI]; 0.934[YRI]
rs2101476	intron_variant	1.0[CEU]
rs6851971	intron_variant	1.0[ASW]; 1.0[CEU]; 1.0[CHB]; 0.911[CHD]; 1.0[GIH]; 0.93[JPT]; 0.822[LWK]; 1.0[MEX]; 1.0[TSI]; 1.0[YRI]
rs11943456	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	1.0[JPT]
rs6842960	intron_variant	0.904[CEU]; 1.0[CHB]; 0.868[JPT]; 0.931[YRI]
rs972446	intron_variant	1.0[CEU]; 1.0[CHB]; 0.868[JPT]; 0.934[YRI]
rs17725110	intron_variant; nc_transcript_variant	1.0[CHB]; 0.917[CHD]; 0.93[JPT]
rs861029	downstream_gene_variant; intron_variant; nc_transcript_variant	0.808[CEU]; 1.0[CHB]; 0.911[CHD]; 0.887[GIH]; 1.0[JPT]; 0.857[TSI]
rs7659095	NMD_transcript_variant; intron_variant; nc_transcript_variant	1.0[CHB]; 1.0[JPT]; 1.0[YRI]
rs17721497	intron_variant; nc_transcript_variant; upstream_gene_variant	1.0[CEU]; 1.0[CHB]; 1.0[CHD]; 1.0[GIH]; 1.0[JPT]; 0.898[MEX]; 1.0[TSI]
rs1979604	downstream_gene_variant	1.0[CEU]; 0.864[CHB]; 1.0[JPT]
rs6858749	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant	0.814[GIH]; 1.0[JPT]
rs819266	intron_variant; nc_transcript_variant	0.823[CHD]; 0.812[JPT]; 0.809[TSI]
rs6830728	intron_variant	1.0[CEU]; 1.0[CHB]; 0.862[JPT]; 0.931[YRI]
rs693367	intron_variant; nc_transcript_variant; upstream_gene_variant	1.0[CHB]; 0.911[CHD]; 0.808[GIH]; 1.0[JPT]; 0.895[TSI]
rs819269	3_prime_UTR_variant; downstream_gene_variant; intron_variant; nc_transcript_variant	0.809[TSI]
rs41324951	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	1.0[CEU]; 1.0[CHB]; 1.0[CHD]; 1.0[GIH]; 1.0[JPT]; 1.0[MEX]; 1.0[TSI]
rs3805383	nc_transcript_variant; non_coding_exon_variant; synonymous_variant	1.0[CHB]; 0.846[CHD]; 0.856[JPT]
rs10021233	downstream_gene_variant; intron_variant; nc_transcript_variant	1.0[CHB]; 0.93[JPT]
rs10462028	3_prime_UTR_variant; downstream_gene_variant	1.0[ASW]; 1.0[CHB]; 1.0[CHD]; 0.892[GIH]; 1.0[JPT]; 1.0[LWK]; 0.817[MEX]; 0.982[MKK]; 0.92[TSI]; 1.0[YRI]
rs17781708	intron_variant; nc_transcript_variant	1.0[CHB]; 0.917[CHD]; 0.856[JPT]
rs10026315	intron_variant; nc_transcript_variant	1.0[CHB]; 0.917[CHD]; 0.856[JPT]
rs6853506	intron_variant	1.0[CEU]; 1.0[CHB]; 1.0[JPT]; 1.0[YRI]
rs17776975	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	1.0[CEU]; 1.0[CHB]; 1.0[CHD]; 1.0[GIH]; 1.0[JPT]; 1.0[MEX]; 1.0[TSI]
rs2130040	intron_variant	1.0[CEU]; 1.0[CHB]; 1.0[JPT]; 1.0[YRI]
rs7698022	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	1.0[CEU]; 1.0[CHB]; 1.0[JPT]; 1.0[YRI]