ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

SNP Report

Basic Info

Name	rs1982406 dbSNP Ensembl
Location	Chr7:50597627(Fwd)
Variant Alleles	A/G
Ancestral Allele	A
Functional Annotation	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant.
Consequence to Transcript	NMD_transcript_variant(ENST00000444733) intron_variant(ENST00000357936; ENST00000444733; ENST00000426377; ENST00000444124; ENST00000431062; ENST00000430300; ENST00000489162; ENST00000380984) nc_transcript_variant(ENST00000489162) upstream_gene_variant(ENST00000454521)
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Ribases M, 2009(b)			Case-control test: lowest P-value=0.022 for genotype analysi...... Case-control test: lowest P-value=0.022 for genotype analysis, P-value=0.1 for allele analysis in adult combined ADHD; lowest P-value=0.0044 for genotype analysis, P-value=0.0087 for allele analysis in all childhood ADHD; lowest P-value=0.00058 for genotype analysis, P-value=0.0031 for allele analysis in childhood combined ADHD. More...	no significance after correcting for multiple comparisons no significance after correcting for multiple comparisons	Significant

SNP related genes (count: 1)

Literature-origin genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
DDC	dopa decarboxylase (aromatic L-amino acid decarboxylase)	7p11	6(5/1/0)

Genes from other sources (count: 0)

SNPs in LD with rs1982406 (count: 19) View in gBrowse (chr7:50572709..50615840 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

Literature-origin SNPs (count: 1)

rs_ID	Functional Annotation	#studies(significant/non-significant/trend)	r²[population]

rs6592961	NMD_transcript_variant; intron_variant	1(1/0/0)	0.869[CHB]; 0.908[CHD]

LD-proxies (count: 18)

rs_ID	Functional Annotation	r²[population]
rs2100280	NMD_transcript_variant; intron_variant	0.811[CEU]; 0.933[CHB]; 0.955[CHD]; 0.928[GIH]; 1.0[JPT]; 0.877[MEX]; 0.972[TSI]
rs3735274	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	0.82[CEU]; 1.0[CHB]; 1.0[CHD]; 0.954[GIH]; 1.0[JPT]; 0.877[MEX]; 0.973[TSI]
rs7777600	NMD_transcript_variant; downstream_gene_variant; intron_variant	0.839[TSI]
rs6592963	NMD_transcript_variant; intron_variant	0.82[CEU]; 0.933[CHB]; 0.955[CHD]; 0.932[GIH]; 1.0[JPT]; 0.877[MEX]; 0.972[TSI]
rs2329364	NMD_transcript_variant; intron_variant	0.863[JPT]
rs17133877	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	0.863[JPT]
rs4585697	NMD_transcript_variant; downstream_gene_variant; intron_variant; upstream_gene_variant	0.933[CHB]; 0.955[CHD]; 0.93[JPT]
rs7809758	NMD_transcript_variant; intron_variant	0.933[CHB]; 0.866[CHD]
rs10249982	NMD_transcript_variant; downstream_gene_variant; intron_variant	0.82[CEU]; 1.0[CHB]; 1.0[JPT]
rs2198144	NMD_transcript_variant; intron_variant	0.933[CHB]
rs9918702	NMD_transcript_variant; downstream_gene_variant; intron_variant	0.82[CEU]; 1.0[CHB]; 0.838[CHD]; 0.932[GIH]; 1.0[JPT]; 0.877[MEX]; 0.972[TSI]
rs12538830	NMD_transcript_variant; downstream_gene_variant; intron_variant	0.815[CEU]; 1.0[CHB]; 0.955[CHD]; 0.932[GIH]; 1.0[JPT]; 0.835[MEX]; 0.972[TSI]
rs10228056	NMD_transcript_variant; downstream_gene_variant; intron_variant; upstream_gene_variant	0.863[JPT]
rs12535064	NMD_transcript_variant; downstream_gene_variant; intron_variant	0.82[CEU]; 1.0[CHB]; 0.953[CHD]; 0.862[GIH]; 1.0[JPT]; 0.874[MEX]; 0.917[TSI]
rs4947584	NMD_transcript_variant; intron_variant	0.933[CHB]; 0.866[CHD]
rs7808025	NMD_transcript_variant; intron_variant	0.869[CHB]; 1.0[CHD]
rs1817074	NMD_transcript_variant; intron_variant	0.869[CHB]
rs10244632	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	1.0[CEU]; 1.0[CHB]; 1.0[JPT]; 0.963[YRI]