ADHDgene Database

SNP Report

Basic Info

Name	rs2042449 dbSNP Ensembl
Location	Chr5:1416646(Fwd)
Variant Alleles	G/A
Ancestral Allele	G
Functional Annotation	intron_variant; nc_transcript_variant; non_coding_exon_variant.
Consequence to Transcript	intron_variant(ENST00000453492; ENST00000513308; ENST00000270349) nc_transcript_variant(ENST00000511750) non_coding_exon_variant(ENST00000511750)
No. of Studies	2 (significant: 1; non-significant: 1; trend: 0)
Source	Literature-origin

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Friedel S, 2007	C/T	C	FAMHAP P-value=0.78 in single marker association analysis FAMHAP P-value=0.78 in single marker association analysis	No association was found with ADHD No association was found with ADHD	Non-significant
Brookes K, 2006	A/G		UNPHASED TDT P-value=0.267; WHAP TDT P-value=0.048 UNPHASED TDT P-value=0.267; WHAP TDT P-value=0.048	significant association was observed in WHAP analysis significant association was observed in WHAP analysis	Significant

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
SLC6A3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	5p15.3	68(42/25/1)

SNPs in LD with rs2042449 (count: 5) View in gBrowse (chr5:1416646..1436102 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

rs_ID	Functional Annotation	r²[population]
rs10040882	intron_variant; upstream_gene_variant	1.0[CEU]; 0.91[JPT]; 0.845[YRI]
rs10053602	intron_variant	1.0[ASW]; 1.0[CEU]; 0.924[CHB]; 0.913[CHD]; 1.0[JPT]; 1.0[MEX]; 0.943[TSI]; 0.924[YRI]
rs2975292	intron_variant; upstream_gene_variant	1.0[CHB]; 1.0[JPT]
rs10052016	intron_variant	1.0[ASW]; 1.0[CEU]; 0.924[CHB]; 0.913[CHD]; 1.0[JPT]; 0.822[MEX]; 0.89[TSI]; 0.924[YRI]
rs9312866	intron_variant	0.941[CEU]; 1.0[MEX]; 0.863[MKK]; 0.943[TSI]