ADHDgene Database

SNP Report

Basic Info

Name	rs2290416 dbSNP Ensembl
Location	Chr8:144657600(Fwd)
Variant Alleles	G/A
Functional Annotation	downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant; synonymous_variant; upstream_gene_variant.
Consequence to Transcript	downstream_gene_variant(ENST00000524397; ENST00000529576; ENST00000442189; ENST00000532741; ENST00000534380; ENST00000462059; ENST00000480946; ENST00000531621; ENST00000419152; ENST00000317198; ENST00000526786; ENST00000530109; ENST00000532645; ENST00000491904; ENST00000529007; ENST00000528382; ENST00000528610; ENST00000534377; ENST00000529272; ENST00000532400; ENST00000423316; ENST00000526838; ENST00000527741; ENST00000524624; ENST00000533833; ENST00000395119; ENST00000488096; ENST00000525583) intron_variant(ENST00000531730) nc_transcript_variant(ENST00000460623; ENST00000531730; ENST00000464332) non_coding_exon_variant(ENST00000460623; ENST00000464332) synonymous_variant(ENST00000340490; ENST00000435154; ENST00000449291; ENST00000426292; ENST00000276844) upstream_gene_variant(ENST00000398882; ENST00000529971; ENST00000529179; ENST00000529247; ENST00000498076)
No. of Studies	1 (significant: 0; non-significant: 0; trend: 1)
Source	Literature-origin

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Lasky-Su J, 2008			P-value=8.51E-06 under Additive model for Total ADHD symptom...... P-value=8.51E-06 under Additive model for Total ADHD symptom count More...	association finding with P-value association finding with P-value	Trend

SNP related genes (count: 3)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
NAPRT1	nicotinate phosphoribosyltransferase domain containing 1	8q24.3	1(0/0/1)

Approved Symbol	Approved Name	Location
C8orf73	chromosome 8 open reading frame 73	8q24.3
EEF1D	eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)	8q24

SNPs in LD with rs2290416 (count: 3) View in gBrowse (chr8:144657600..144691512 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

rs_ID	Functional Annotation	r²[population]
rs2278898	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	0.896[JPT]
rs4874169	NMD_transcript_variant; intron_variant; nc_transcript_variant	0.899[CEU]
rs3793371	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant; upstream_gene_variant	1.0[ASW]; 0.899[CEU]; 0.808[CHD]; 0.823[JPT]; 1.0[YRI]