ADHDgene Database

SNP Report

Basic Info

Name	rs737865 dbSNP Ensembl
Location	Chr22:19930121(Fwd)
Variant Alleles	A/G
Ancestral Allele	A
Functional Annotation	intron_variant; nc_transcript_variant; upstream_gene_variant.
Consequence to Transcript	intron_variant(ENST00000407537; ENST00000403184; ENST00000403710; ENST00000467943; ENST00000361682) nc_transcript_variant(ENST00000467943) upstream_gene_variant(ENST00000400519; ENST00000400525; ENST00000400521; ENST00000474308; ENST00000535882; ENST00000334363; ENST00000496729)
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Turic D, 2005(b)	G/A		allelic TRANSMIT P-value (10,000 simulations)=0.52, X^2<...... allelic TRANSMIT P-value (10,000 simulations)=0.52, X²=0.411 More...	did not show preferential transmission of any allele did not show preferential transmission of any allele	Non-significant

SNP related genes (count: 2)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
COMT	catechol-O-methyltransferase	22q11.21	25(5/20/0)

Approved Symbol	Approved Name	Location
TXNRD2	thioredoxin reductase 2	22q11.21

SNPs in LD with rs737865 (count: 8) View in gBrowse (chr22:19921137..19933048 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

rs_ID	Functional Annotation	#studies(significant/non-significant/trend)	r²[population]

rs2020917	intron_variant; nc_transcript_variant; upstream_gene_variant	1(0/1/0)	1.0[CEU]; 1.0[CHB]; 1.0[CHD]; 0.97[GIH]; 1.0[JPT]; 0.925[MEX]; 0.946[TSI]
rs737866	intron_variant; nc_transcript_variant; upstream_gene_variant	1(0/1/0)	1.0[ASW]; 1.0[CEU]; 1.0[CHB]; 1.0[CHD]; 1.0[GIH]; 1.0[JPT]; 0.952[LWK]; 1.0[MEX]; 1.0[MKK]; 1.0[TSI]; 1.0[YRI]

rs_ID	Functional Annotation	r²[population]
rs9605031	intron_variant; nc_transcript_variant; upstream_gene_variant	1.0[CEU]; 1.0[CHB]; 1.0[CHD]; 0.97[GIH]; 1.0[JPT]; 0.925[MEX]; 0.82[MKK]; 0.946[TSI]
rs9606189	intron_variant; nc_transcript_variant; upstream_gene_variant	1.0[CEU]; 1.0[CHB]; 1.0[JPT]
rs9605030	intron_variant; nc_transcript_variant; upstream_gene_variant	0.949[CHB]; 0.942[CHD]; 1.0[JPT]
rs8140265	intron_variant; nc_transcript_variant; upstream_gene_variant	1.0[CEU]; 1.0[CHB]; 1.0[CHD]; 0.97[GIH]; 1.0[JPT]; 0.925[MEX]; 0.82[MKK]; 0.946[TSI]
rs8185002	intron_variant; nc_transcript_variant; upstream_gene_variant	1.0[CEU]; 0.949[CHB]; 1.0[CHD]; 0.969[GIH]; 1.0[JPT]; 0.902[LWK]; 1.0[MEX]; 0.959[MKK]; 1.0[TSI]; 0.931[YRI]
rs5748484	intron_variant; nc_transcript_variant; upstream_gene_variant	1.0[CEU]; 1.0[CHB]; 1.0[JPT]