ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

SNP Report

Basic Info

Name	rs941298 dbSNP Ensembl
Location	Chr7:73125263(Fwd)
Variant Alleles	G/A
Ancestral Allele	G
Functional Annotation	intron_variant; nc_transcript_variant; upstream_gene_variant.
Consequence to Transcript	intron_variant(ENST00000462135; ENST00000395156; ENST00000470878; ENST00000222812; ENST00000395155; ENST00000395154) nc_transcript_variant(ENST00000462135; ENST00000470878) upstream_gene_variant(ENST00000578924)
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Sanchez-Mora, C., 2012			P-value=0.012, Genotype12+22 vs11: P-value=0.012, OR(95%CI)=...... P-value=0.012, Genotype12+22 vs11: P-value=0.012, OR(95%CI)=1.32(1.06¨C1.65); Genotypes22 vs11+12: P-value=0.020, OR(95%CI)=1.52(1.07¨C2.17); allelic P-value=0.003, OR(95%CI)=1.29(1.09¨C1.52) More...	When adults with ADHD were considered, nominal differences w...... When adults with ADHD were considered, nominal differences were found for nine SNPs located in five genes. After applying a FDR of 15%, only the four SNPs in STX1A remained associated with adulthood ADHD. More...	Significant

SNP related genes (count: 2)

Literature-origin genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
STX1A	syntaxin 1A (brain)	7q11.2	3(2/1/0)

Genes from other sources (count: 1)

Approved Symbol	Approved Name	Location
MIR4284	microRNA 4284	7

SNPs in LD with rs941298 (count: 22) View in gBrowse (chr7:73081831..73125263 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

Literature-origin SNPs (count: 1)

rs_ID	Functional Annotation	#studies(significant/non-significant/trend)	r²[population]

rs4363087	3_prime_UTR_variant; NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant; upstream_gene_variant	1(1/0/0)	0.831[CEU]

LD-proxies (count: 21)

rs_ID	Functional Annotation	r²[population]
rs7778762	3_prime_UTR_variant; NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant	1.0[CEU]; 0.888[CHB]; 1.0[JPT]; 0.956[MEX]; 0.975[TSI]
rs11769825	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	0.953[CEU]; 0.888[CHB]; 1.0[JPT]; 0.87[MEX]
rs4717806	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	0.952[CEU]; 0.888[CHB]; 1.0[JPT]
rs867500	3_prime_UTR_variant; NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant	0.952[CEU]; 0.888[CHB]; 1.0[JPT]
rs4644119	downstream_gene_variant	0.953[CEU]; 0.888[CHB]; 0.927[JPT]
rs1527454	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	1.0[CEU]; 0.888[CHB]; 1.0[JPT]; 0.956[MEX]; 0.975[TSI]
rs6950314	upstream_gene_variant	0.817[CEU]; 0.888[CHB]; 0.856[JPT]
rs1001220	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant	0.831[CEU]
rs941297	downstream_gene_variant	0.953[CEU]; 0.888[CHB]; 1.0[JPT]
rs2293487	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	1.0[CEU]; 0.888[CHB]; 1.0[JPT]; 0.956[MEX]; 0.975[TSI]
rs4717803	downstream_gene_variant; upstream_gene_variant	1.0[CEU]; 0.888[CHB]; 1.0[JPT]; 0.956[MEX]; 0.975[TSI]
rs2141166	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	0.953[CEU]; 0.888[CHB]; 1.0[JPT]
rs2293490	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant; upstream_gene_variant	0.952[CEU]; 0.888[CHB]; 1.0[JPT]; 0.956[MEX]; 0.975[TSI]
rs2293488	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	1.0[CEU]; 0.888[CHB]; 1.0[JPT]; 0.956[MEX]; 0.975[TSI]
rs4717101	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	1.0[CEU]; 0.888[CHB]; 1.0[JPT]; 0.956[MEX]; 0.975[TSI]
rs10949826	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	1.0[CEU]; 0.888[CHB]; 1.0[JPT]; 0.956[MEX]; 0.975[TSI]
rs2293489	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant; upstream_gene_variant	1.0[CEU]; 0.888[CHB]; 1.0[JPT]; 0.956[MEX]; 0.975[TSI]
rs941299	intron_variant; nc_transcript_variant; upstream_gene_variant	1.0[ASW]; 1.0[CEU]; 1.0[CHB]; 1.0[CHD]; 0.954[GIH]; 1.0[JPT]; 1.0[LWK]; 1.0[MEX]; 1.0[MKK]; 1.0[TSI]; 1.0[YRI]
rs12531606	downstream_gene_variant; upstream_gene_variant	0.953[CEU]; 0.888[CHB]; 1.0[JPT]; 0.865[MEX]
rs2141167	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	0.953[CEU]; 0.888[CHB]; 1.0[JPT]
rs10267271	downstream_gene_variant	0.831[CEU]; 0.81[TSI]