ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Study Report

Basic Info

Reference	Zoroglu SS, 200312606840
Citation	Zoroglu S. S., Erdal M. E., Erdal N., Ozen S., Alasehirli B. and Sivasli E. (2003) "No evidence for an association between the T102C and 1438 G/A polymorphisms of the serotonin 2A receptor gene in attention deficit/hyperactivity disorder in a Turkish population." Neuropsychobiology, 47(1): 17-20.
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	70 patients with ADHD and 100 healthy volunteers
Predominant Ethnicity	Turkish
Population	Turkey
Gender	54 male and 16 female patients; 65 male and 35 female controls
Age Group	Children/Adolescents : case: 6-17 years (mean=10.2, SD=3.9); control: 6-17 years (mean=10.2, SD=4.5)

Detail Info

Summary	The purpose of this study was to examine the relationship between ADHD and two polymorphisms (T102C and 1438 G/A) in the 5-HT2A gene in a sample of Turkish children. Using the PCR technique, these polymorphisms were assessed in 70 patients with ADHD and in 100 healthy controls. There was no significant difference between the frequencies of the T, C, G and A alleles of both groups. No association was found between the studied polymorphisms of the 5-HT2A gene and ADHD in this sample consisting of Turkish children. Overall, their results suggest that the investigated 5-HT2A polymorphisms are not major susceptibility factors in the etiology of ADHD.
Total Sample	Seventy patients with ADHD and 100 healthy volunteers were included in the study. There were 54 male and 16 female patients with ADHD with ages ranging from 6 to 17 years (mean=10.2, SD=3.9), and 65 male and 35 female controls with ages ranging from 6 to 17 years (mean=10.2, SD=4.5).
Sample Collection	ADHD patients were recruited from the Child and Adolescent Psychiatry Clinic of the University Hospital of Gaziantep, Turkey.
Diagnosis Description	The diagnosis of ADHD was made on the basis of DSM-IV criteria. All ADHD patients had the symptoms inattention and hyperactivity/impulsivity, which was recognized by DSM-IV as ADHD combined type. The clinical assessment included the following parts. (1) The Child Behavior Checklist (CBCL); (2) The Conners Parent Rating Scale; (3) The Connors Teacher Rating Scale; (4) The ADHD Rating Scale IV; (5) The Schedule for Affective Disorders and Schizophrenia for School-Age Children, lifetime version.
Technique	Genomic DNA was extracted according to standard procedures. PCR amplification of the 5-HT2A T102C and 1439 G/A polymorphisms were carried out using the primers and methods described earlier [14, 23]. The laboratory personnel were blind to the origin and diagnoses of the DNA samples.
Analysis Method	For the statistical analysis, SPSS (10.0 version) for Windows computing program was used. For mean scores of clinical rating scales and age, comparisons between the ADHD and the control group were performed by using Student t tests. The X² test was applied to test differences in the allele distribution between the group of ADHD and healthy controls. A two-tailed type I error rate of 5% was chosen for the analyses.
Result Description	There was no significant difference between the frequencies of the T, C, G and A alleles of both groups. No association was found between the studied polymorphisms of the 5-HT2A gene and ADHD in this sample consisting of Turkish children. Overall, their results suggest that the investigated 5-HT2A polymorphisms are not major susceptibility factors in the etiology of ADHD.

Other variant reported by this study (count: 2)

Variant Name	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
HTR2A promoter 1438G/A	G/A		allelic chi-square test P-value=0.78, X²(1df)=0.0...... allelic chi-square test P-value=0.78, X²(1df)=0.08; genotypic chi-square test P-value=0.83, X²(2df)=0.37 More...	no significant differences between patients and controls were found neither in the distribution of the genotypes nor in the allele frequency	Non-significant
HTR2A T102C	T/C		allelic chi-square test P-value=0.89, X²(1df)=0.0...... allelic chi-square test P-value=0.89, X²(1df)=0.02; genotypic chi-square test P-value=0.53, X²(2df)=1.25 More...	no significant differences between patients and controls were found neither in the distribution of the genotypes nor in the allele frequency	Non-significant

Genes reported by this study (count: 1)