Study Report
Basic Info
Reference |
Comings DE, 19957786965
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Citation |
Comings D. E., Gade R., Muhleman D. and Sverd J. (1995) "No association of a tyrosine hydroxylase gene tetranucleotide repeat polymorphism in autism, Tourette syndrome, or ADHD." Biol Psychiatry, 37(7): 484-6.
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Study Design |
case-control |
Study Type |
Candidate-gene association study |
Sample Size |
74 ADHD patients and 89 controls |
Predominant Ethnicity |
USA |
Population |
USA |
Detail Info
Summary |
In this study, they examined the possibility that the polymorphic tetranucleotide in intron 1 of the TH gene might show an association with other disorders which often display considerable mood liability. |
Total Sample |
74 ADHD patients and 89 controls |
Sample Collection |
The subjects with TS, ADHD, and autism were from the City of Hope National Medical Center Tourette syndrome-ADHD-autism clinic. The controls consisted of unrelated grandparents from CEPH families. |
Diagnosis Description |
All met the DSM-III-R criteria (APA 1987) for their respective disorders, based on clinical interviews. |
Technique |
The polymorphic tetranucleotide repeat in intron 1 of the TH gene was determined using the technique of Polymeropoulos et al (1991). |
Analysis Method |
logistic regression analysis |
Result Description |
All patient groups showed no significant differences in the distribution of the five repeat-size alleles compared to controls. |
Other variant reported by this study (count: 1)
Variant Name |
Allele Change |
Risk Allele |
Statistical Values |
Author Comments |
Result of Statistical Analysis |
TH intron1 (TCAT)n |
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P-value>0.05, X2=3.30
P-value>0.05, X2=3.30
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All patient groups showed no significant differences in the distribution of the five repeat-size alleles compared to controls. |
Non-significant
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Genes reported by this study (count: 1)
Gene |
Statistical Values/Author Comments |
Result of Statistical Analysis |
TH |
ADHD patient showed no significant differences in the distri......
ADHD patient showed no significant differences in the distribution of the five repeat-size alleles compared to controls.
More...
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Non-significant
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