ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Study Report

Basic Info

Reference	Comings DE, 19957786965
Citation	Comings D. E., Gade R., Muhleman D. and Sverd J. (1995) "No association of a tyrosine hydroxylase gene tetranucleotide repeat polymorphism in autism, Tourette syndrome, or ADHD." Biol Psychiatry, 37(7): 484-6.
Study Design	case-control
Study Type	Candidate-gene association study
Sample Size	74 ADHD patients and 89 controls
Predominant Ethnicity	USA
Population	USA

Detail Info

Summary	In this study, they examined the possibility that the polymorphic tetranucleotide in intron 1 of the TH gene might show an association with other disorders which often display considerable mood liability.
Total Sample	74 ADHD patients and 89 controls
Sample Collection	The subjects with TS, ADHD, and autism were from the City of Hope National Medical Center Tourette syndrome-ADHD-autism clinic. The controls consisted of unrelated grandparents from CEPH families.
Diagnosis Description	All met the DSM-III-R criteria (APA 1987) for their respective disorders, based on clinical interviews.
Technique	The polymorphic tetranucleotide repeat in intron 1 of the TH gene was determined using the technique of Polymeropoulos et al (1991).
Analysis Method	logistic regression analysis
Result Description	All patient groups showed no significant differences in the distribution of the five repeat-size alleles compared to controls.

Other variant reported by this study (count: 1)

Genes reported by this study (count: 1)