ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Study Report

Basic Info

Reference	Zhang HY, 201120599404
Citation	Zhang H., Zhu S., Zhu Y., Chen J., Zhang G. and Chang H. (2011) "An association study between SNAP-25 gene and attention-deficit hyperactivity disorder." Eur J Paediatr Neurol, 15(1): 48-52.
Study Design	case-control and family-based
Study Type	Candidate-gene association study
Sample Size	102 trios and 98 healthy children as controls
Predominant Ethnicity	Mongoloid
Population	China
Gender	90 boys and 12 girls in the ADHD group, 78 boys and 20 girls in the non-ADHD group
Age Group	Children/Adolescents : mean age 8.7,SD=2.2 years for cases, mean age 11.3, SD=3.7 for controls

Detail Info

Summary	They characterized two single-nucleotide polymorphisms (rs362549, rs363006) and one microsatellite [5'-UTR (TAAA)n] of SNAP-25. The association of these variants with ADHD was assessed in 102 trios collected from 90 male and 12 female probands. Transmission disequilibriumtest (TDT) analysis showed that none of the polymorphic alleles were preferentially transmitted to the probands. Quantitative analysis was also conducted to assess the relationship between these marker alleles and the severity of ADHD symptoms. Analysis of the DSM-IV subtypes indicated that a significant association was identified between SNP rs362549 and ADHD subtypes (P-value=0.0047). This is the first report of an association between SNAP-25 and ADHD in Chinese subjects of Han descent. They still support the premise that SNAP-25 is a genetic susceptibility factor for ADHD.
Total Sample	The ADHD group (n=102) was comprised of children (90 boys and 12 girls) of average intelligence with an average age of mean 8.7,SD=2.2 years, who had been clinically diagnosed with ADHD. The parents (n=204) from 102 nuclear families were assigned to the parents of ADHD group. The non-ADHD control group (n=98) included healthy children (78 boys and 20 girls) of average intelligence with an average age of mean 11.3,SD=3.7 years.
Sample Collection	Han Chinese descent
Diagnosis Description	All probands fulfilled the DSM-IV diagnostic criteria for ADHD. The diagnosis was made on the basis of biological parents' and teachers' ratings of the Conners' questionnaire (PSQ & TRS).
Technique	The E.Z.N.A Micro-Spin DNA Extraction Kit (Omega Co., United Kingdom) was used to extract total DNA from the saliva of subjects in the ADHD group and the blood of subjects in the other two groups. All DNA samples from each subject of the three groups were analyzed using Taqman amplification of the region followed by GeneScan fragment analysis. Genotyping was performed using the ABI PRISM 7900 Sequence Detection System. For more details, please refer to the original article.
Analysis Method	The transmission disequilibrium test (TDT) was performed by manual method to detect the distorted transmission of alleles or haplotypes.
Result Description	Transmission disequilibriumtest (TDT) analysis showed that none of the polymorphic alleles were preferentially transmitted to the probands. Analysis of the DSM-IV subtypes indicated that a significant association was identified between SNP rs362549 and ADHD subtypes (P-value=0.0047).

SNPs reported by this study (count: 2)

SNP	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
rs363006			TDT P-value>0.05	showed a non-significant association with ADHD showed a non-significant association with ADHD	Non-significant
rs362549	A/G		TDT P-value=0.0047, X²=8.00 for inattentive subtype, TDT P-value=0.0423, X²=4.122 for ADHD-C subtype; Cross-tab P-value=0.0247, X²=5.0467 for ADHD-I subtype, Cross-tab P-value=0.0955, X²=2.779 for ADHD-C subtype	showed surprisingly a statistical significant trend of biase...... showed surprisingly a statistical significant trend of biased transmission in ADHD-IA subtype and ADHD-C subtype. By correcting with cross-tab analysis, it still remains statistical significantin in ADHD-IA subtype, but that in ADHD-C subtype showed only a trend but not significant. More...	Significant

Other variant reported by this study (count: 1)

Genes reported by this study (count: 1)