ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Study Report

Basic Info

Reference	McEvoy B, 200212210284
Citation	McEvoy B., Hawi Z., Fitzgerald M. and Gill M. (2002) "No evidence of linkage or association between the norepinephrine transporter (NET) gene polymorphisms and ADHD in the Irish population." Am J Med Genet, 114(6): 665-6.
Study Design	family-based
Study Type	Candidate-gene association study
Sample Size	118 children from 111 families.
Predominant Ethnicity	Caucasian
Population	Ireland
Gender	85% male
Age Group	Children/Adolescents

Detail Info

Summary	To investigate whether the NET gene is a candidate locus in predisposing to ADHD, two single nucleotide polymorphisms (SNPs) mapped to intron 7 and 9 of the NET were genotyped in ADHD nuclear families from Ireland. All cases were diagnosed according to the DSM-IV criteria for ADHD. Eighty-five percent of the ADHD cases were male. Transmission disequilibrium test (TDT) was used to examine the presence or the absence of linkage or association between NET gene polymorphisms and ADHD.
Total Sample	118 children from 111 families [Daly et al., 1999].
Diagnosis Description	DSM-IV
Technique	Stober et al., 1996
Analysis Method	LD between the two loci was measured using the program GOLD. Transmission disequilibrium test (TDT) was used to examine the presence or the absence of linkage or association between NET gene polymorphisms and ADHD. Haplotype analysis was conducted using the programme TRANSMIT.
Result Description	The two loci are in strong LD with each other (D'=0.71, P=0.00000). TDT analysis showed no distortion in the transmission of any allele to the ADHD cases. Haplotype analysis showed no distortion in the transmission of marker haplotypes.

Other variant reported by this study (count: 2)

Variant Name	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
SLC6A2 intron7 C/A BsrDI	C/A		TDT P-value=0.55 TDT P-value=0.55	No distortion in the transmission of any allele to the ADHD cases.	Non-significant
SLC6A2 intron9 G/C MnlI	G/C		TDT P-value=0.88 TDT P-value=0.88	No distortion in the transmission of any allele to the ADHD cases.	Non-significant

Genes reported by this study (count: 1)