ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Study Report

Basic Info

Reference	Cho SC, 2008(b)18314873
Citation	Cho S. C., Kim J. W., Kim B. N., Hwang J. W., Park M., Kim S. A., Cho D. Y., Yoo H. J., Chung U. S., Son J. W. and Park T. W. (2008) "Possible association of the alpha-2A-adrenergic receptor gene with response time variability in attention deficit hyperactivity disorder." Am J Med Genet B Neuropsychiatr Genet, 147B(6): 957-63.
Study Design	case-control and family-based
Study Type	Candidate-gene association study
Sample Size	186 children with ADHD and their parents, 150 normal controls
Predominant Ethnicity	Mongoloid
Population	Korea
Gender	162 boys for cases, 131 boys for controls
Age Group	Children/Adolescents : mean 9.2,SD=2.3 years

Detail Info

Summary	The aims of this study were to examine the association of the ADRA2A MspI and DraI polymorphisms with ADHD in Korean subjects, and to determine the relationship between the genotypes of these two polymorphisms and the candidate endophenotypes, as measured by the continuous performance test (CPT). In a case-control study, they assessed 186 ADHD probands and 150 normal controls. One hundred eight trios were studied in a family based association analysis. The transmission disequilibrium test (TDT) analysis showed preferential transmission of the C allele of the DraI polymorphism (X²=5.88, P-value=0.015). In the haplotype analyses, a trend of over-transmission of haplotype C/C was observed (X²=3.80, P-value= 0.051). The homozygous subjects for the C allele (C/C genotype) at the DraI polymorphism showed a trend toward a higher mean T-score with respect to the response time variability profiles of the CPT than did those with the other genotypes (C/T+T/T genotypes; P-value=0.042). The homozygous subjects for the G allele (G/G genotype) at the MspI polymorphism showed a tendency to have a lower mean T-score with respect to the response time variability profiles of the CPT (P-value=0.068). The results of this study provide important evidence for the involvement of the ADRA2A MspI and DraI polymorphisms in the etiology of ADHD in Korean subjects.
Total Sample	The present study included 186 children with ADHD (mean 9.2 SD=2.3 years), consisting of 162 boys and 24 girls, and their parents. The control group included 150 normal children (mean 9.4, SD=0.6 years), consisting of 131 boys and 19 girls, who were recruited from two elementary schools in Seoul, Korea.
Diagnosis Description	The Kiddie-Schedule for Affective Disorders and Schizophrenia- Present and Lifetime Version (K-SADS-PL) was the tool used for the diagnosis of ADHD in the present study.
Technique	Genomic DNA was extracted from whole blood lymphocytes using a G-DEXTM II Genomic DNA Extraction Kit (Intron, Korea). The detection of SNP was based upon analysis of primer extension products generated from previously amplified genomic DNA using a chip-based MALDI-TOF mass spectrometry platform (Sequenom, Inc., San Diego, CA).
Analysis Method	The allele frequencies were estimated by counting, and the Hardy-Weinberg equilibrium was calculated based on these allele frequencies, using the goodness-of-fit X² (Chi-square) test. The family based association of the ADRA2A polymorphisms with ADHD was investigated using the transmission disequilibrium test (TDT).
Result Description	The results of this study provide important evidence for the involvement of the ADRA2A MspI and DraI polymorphisms in the etiology of ADHD in Korean subjects.

SNPs reported by this study (count: 2)

SNP	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
rs583668			genotype or allele frequencies P-value>0.05; TDT P-value=0.015, X²=5.88 for allele C	showed preferential transmission of the C allele showed preferential transmission of the C allele	Significant
rs1800544			genotype or allele frequencies P-value>0.05	no significant differences in the genotype or allele frequen...... no significant differences in the genotype or allele frequencies of the ADRA2A MspI and DraI polymorphisms between the ADHD and control groups More...	Non-significant

Genes reported by this study (count: 1)