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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Study Report

Basic Info

Reference	Wohl M, 200818214864
Citation	Wohl M., Boni C., Asch M., Cortese S., Orejarena S., Mouren M. C., Gorwood P. and Purper-Ouakil D. (2008) "Lack of association of the dopamine transporter gene in a French ADHD sample." Am J Med Genet B Neuropsychiatr Genet, 147B(8): 1509-10.
Study Design	family-based
Study Type	Candidate-gene association study
Sample Size	146 affected children with 106 trios and 40 duos
Predominant Ethnicity	Caucasian
Population	French
Gender	87% boys
Age Group	Children/Adolescents : 6-16 years

Detail Info

Summary	They analyzed a sample of 146 ADHD children and their parents, with a transmission disequilibrium test (TDT) design, assessing age, inattention, and hyperactivity dimensions and total score of the ADHD Rating Scale, the number of errors and the total score at Stroop Color-Word test, and the total score at the Trail Making Test. The TDT for 10-repeat (10-R) allele shows a perfect lack of transmission bias and PBAT analyses showed no role of this polymorphism for any of the studied endophenotypes. Lack of statistical power is always a possibility, but with a sample size above the average of the majority of previous studies, and an odds ratio (number of transmitted versus untransmitted 10-R allele) of 1.00 exactly, this possibility may be considered as not very likely.
Total Sample	The final sample consisted of 146 affected children with 106 trios and 40 duos (82% child-mother). Main characteristics of the samplewere: 86% Caucasians, 73% combined ADHD subtype, 87% boys.
Sample Collection	86% Caucasians
Diagnosis Description	They recruited a French clinical sample of ADHD children aged 6-16, assessed for diagnostic subtype and comorbidity (DSM IV-TR), the severity of ADHD symptoms (ADHD Rating Scale), cognitive function after at least 24 hr off methylphenidate medication (Stroop Color-Word test and Trail Making Test).
Technique	Probands and their parents were genotyped for the 40 bp VNTR polymorphism of the DAT1 gene.
Analysis Method	a TDT design was used, including trios and duos
Result Description	The TDT for 10-repeat allele shows a perfect lack of transmission bias and PBAT analyses showed no role of this polymorphism for any of the studied endophenotypes. Lack of statistical power is always a possibility, but with a sample size above the average of the majority of previous studies, and an odds ratio of 1.00 exactly, this possibility may be considered as not very likely.

Other variant reported by this study (count: 1)

Genes reported by this study (count: 1)