ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	AMACR
Symbol Alias	RACE
Approved Name	alpha-methylacyl-CoA racemase
Location	5p13.2-q11.1
Position	chr5:33986283-34008220, -
External Links	HGNC: 451 Entrez Gene: 23600 Ensembl: ENSG00000242110 UCSC: uc003jig.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
5p13	chr5:28900000-42500000	3 (1/1/1)

Gene related GO terms (count: 11)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0033540	fatty acid beta-oxidation using acyl-CoA oxidase	Biological Process		1
GO:0044255	cellular lipid metabolic process	Biological Process		30
GO:0005777	peroxisome	Cellular Component	IDA[11060344]	15
GO:0005739	mitochondrion	Cellular Component	IDA[11060344]	183
GO:0005737	cytoplasm	Cellular Component	IDA[15941950]	690
GO:0005102	receptor binding	Molecular Function	IPI[11060344]	61
GO:0008206	bile acid metabolic process	Biological Process	IDA[10655068]	8
GO:0008111	alpha-methylacyl-CoA racemase activity	Molecular Function	IDA[7649182]; IMP[10655068]	1
GO:0006699	bile acid biosynthetic process	Biological Process		4
GO:0005782	peroxisomal matrix	Cellular Component		5

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa00120	Primary bile acid biosynthesis	4	Bile acids are steroid carboxylic acids derived from cholest...... Bile acids are steroid carboxylic acids derived from cholesterol in vertebrates. The primary bile acids, cholic acid and chenodeoxycholic acid, are synthesized in the liver and conjugated with taurine or glycine before secretion via bile into the intestine. The conversion from cholesterol to cholic and chenodeoxycholic acids involves four steps: 1) the initiation of synthesis by 7alpha-hydroxylation of sterol precursors, 2) further modifications to the ring structures, 3) side-chain oxidation and shortening (cleavage) by three carbons, and 4) conjugation of the bile acid with taurine or glycine. More...
hsa04146	Peroxisome	9	Peroxisomes are essential organelles that play a key role in...... Peroxisomes are essential organelles that play a key role in redox signalling and lipid homeostasis. They contribute to many crucial metabolic processes such as fatty acid oxidation, biosynthesis of ether lipids and free radical detoxification. The biogenesis of peroxisomes starts with the early peroxins PEX3, PEX16 and PEX19 and proceeds via several steps. The import of membrane proteins into peroxisomes needs PEX19 for recognition, targeting and insertion via docking at PEX3. Matrix proteins in the cytosol are recognized by peroxisomal targeting signals (PTS) and transported to the docking complex at the peroxisomal membrane. Peroxisomes' deficiencies lead to severe and often fatal inherited peroxisomal disorders (PD). PDs are usually classified in two groups. The first group is disorders of peroxisome biogenesis which include Zellweger syndrome, and the second group is single peroxisomal enzyme deficiencies. More...
hsa01100	Metabolic pathways	237

Genes shared at least 5 GO terms with AMACR (count: 2)

Gene Symbol	Pathway Count	Pathway List
BAAT	6	small molecule metabolic process; peroxisome; receptor binding; bile acid metabolic process; bile acid biosynthetic process; peroxisomal matrix;
PRDX5	5	peroxisome; mitochondrion; cytoplasm; receptor binding; peroxisomal matrix;

Genes shared at least 2 KEGG pathways with AMACR (count: 4)

Gene Symbol	Pathway Count	Pathway List
BAAT	3	Primary bile acid biosynthesis; Peroxisome; Metabolic pathways;
CYP27A1	2	Primary bile acid biosynthesis; Metabolic pathways;
HSD3B7	2	Primary bile acid biosynthesis; Metabolic pathways;
MLYCD	2	Peroxisome; Metabolic pathways;

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Region: chr5:33986283..34008220 View in gBrowse