ADHDgene Database

Gene Report

Basic Info

Approved Symbol	DOC2A
Approved Name	double C2-like domains, alpha
Location	16p11.2
Position	chr16:30016835-30022401, -
External Links	HGNC: 2985 Entrez Gene: 8448 Ensembl: ENSG00000149927 UCSC: uc002dvn.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 4)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_16	chr16:29563594-30367556 (NCBI Build 36.1 (hg18))	803963	16p11.2	Loss
CNV_Williams[2010]_34	chr16:29342178-31155425 (NCBI Build 36.1 (hg18))	1813248	16p11.2	Loss	De novo
CNV_Williams[2010]_39	chr16:29342178-31155425 (NCBI Build 36.1 (hg18))	1813247	16p11.2	Gain
CNV_Jarick[2012]_35	chr16:29554843-30085308 (NCBI36 / hg18)	530466	16p11.2	del

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005215	transporter activity	Molecular Function		41
GO:0005764	lysosome	Cellular Component		31
GO:0007268	synaptic transmission	Biological Process	TAS[7826360]	96
GO:0005515	protein binding	Molecular Function	IPI[18354201]	910
GO:0005544	calcium-dependent phospholipid binding	Molecular Function		6
GO:0043005	neuron projection	Cellular Component		35
GO:0030672	synaptic vesicle membrane	Cellular Component		15
GO:0016079	synaptic vesicle exocytosis	Biological Process		5
GO:0007399	nervous system development	Biological Process	TAS[7826360]	54
GO:0030054	cell junction	Cellular Component		77
GO:0017158	regulation of calcium ion-dependent exocytosis	Biological Process	IMP[18354201]	5

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with DOC2A (count: 5)

Gene Symbol	Pathway Count	Pathway List
SYT1	9	transporter activity; synaptic transmission; protein binding; calcium-dependent phospholipid binding; neuron projection; synaptic vesicle membrane; synaptic vesicle exocytosis; cell junction; regulation of calcium ion-dependent exocytosis;
SYT2	6	transporter activity; synaptic transmission; protein binding; calcium-dependent phospholipid binding; synaptic vesicle membrane; cell junction;
SYT7	5	transporter activity; lysosome; synaptic vesicle membrane; cell junction; regulation of calcium ion-dependent exocytosis;
STX1A	5	synaptic transmission; protein binding; neuron projection; synaptic vesicle membrane; cell junction;
VAMP2	5	synaptic transmission; protein binding; neuron projection; synaptic vesicle membrane; cell junction;

Genes shared at least 2 KEGG pathways with DOC2A (count: 0)

View in gBrowse

Region: chr16:30016835..30022401 View in gBrowse