Gene Report
Basic Info
Approved Symbol |
DPAGT1
|
Previous Symbol |
DPAGT2, DPAGT |
Symbol Alias |
GPT, D11S366, DGPT, ALG7, CDG-Ij |
Approved Name |
dolichyl-phosphate (UDP-N-acetylglucosamine) N-acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase) |
Location |
11q23.3 |
Position |
chr11:118967213-118979041, - |
External Links |
HGNC: 2995
Entrez Gene: 1798
Ensembl: ENSG00000172269
UCSC: uc001pvi.2
|
No. of Studies |
0 (significant: 0; non-significant: 0; trend: 0) |
Source |
Mapped by significant region |
Gene related studies (count: 0)
Gene related SNPs (count: 0)
Gene related CNVs (count: 0)
Gene related other variant (count: 0)
Gene related regions (count: 1)
Gene related GO terms (count: 16)
Gene related KEGG pathways (count: 2)
ID |
Name |
No. of Genes in ADHDgene |
Brief Description |
hsa00510 |
N-Glycan biosynthesis |
11 |
N-glycans or asparagine-linked glycans are major constituent......
N-glycans or asparagine-linked glycans are major constituents of glycoproteins in eukaryotes. N-glycans are covalently attached to asparagine with the consensus sequence of Asn-X-Ser/Thr by an N-glycosidic bond, GlcNAc b1- Asn. Biosynthesis of N-glycans begins on the cytoplasmic face of the ER membrane with the transferase reaction of UDP-GlcNAc and the lipid-like precursor P-Dol (dolichol phosphate) to generate GlcNAc a1- PP-Dol. After sequential addition of monosaccharides by ALG glycosyltransferases [MD:M00055], the N-glycan precursor is attached by the OST (oligosaccharyltransferase) complex to the polypeptide chain that is being synthesized and translocated through the ER membrane. The protein-bound N-glycan precursor is subsequently trimmed, extended, and modified in the ER and Golgi by a complex series of reactions catalyzed by membrane-bound glycosidases and glycosyltransferases. N-glycans thus synthesized are classified into three types: high-mannose type, complex type, and hybrid type. Defects in N-glycan biosynthesis lead to a variety of human diseases known as congenital disorders of glycosylation [DS:H00118 H00119].
More...
|
hsa01100 |
Metabolic pathways |
237 |
|
Genes shared at least 5 GO terms with DPAGT1 (count: 8)
Genes shared at least 2 KEGG pathways with DPAGT1 (count: 10)
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