ADHDgene Database

Gene Report

Basic Info

Approved Symbol	MGAT4B
Symbol Alias	GnT-Ivb
Approved Name	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B
Previous Name	mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isoenzyme B
Location	5q35
Position	chr5:179224597-179233952, -
External Links	HGNC: 7048 Entrez Gene: 11282 Ensembl: ENSG00000161013 UCSC: uc003mks.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Jarick[2012]_14	chr5:178157153-180497731 (NCBI36 / hg18)	2340579	5q35.3	dup

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 8)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0043687	post-translational protein modification	Biological Process		37
GO:0044267	cellular protein metabolic process	Biological Process		64
GO:0016021	integral to membrane	Cellular Component		845
GO:0018279	protein N-linked glycosylation via asparagine	Biological Process		24
GO:0006491	N-glycan processing	Biological Process	TAS[10372966]	2
GO:0008454	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity	Molecular Function		1
GO:0000139	Golgi membrane	Cellular Component		95
GO:0046872	metal ion binding	Molecular Function		170

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa00510	N-Glycan biosynthesis	11	N-glycans or asparagine-linked glycans are major constituent...... N-glycans or asparagine-linked glycans are major constituents of glycoproteins in eukaryotes. N-glycans are covalently attached to asparagine with the consensus sequence of Asn-X-Ser/Thr by an N-glycosidic bond, GlcNAc b1- Asn. Biosynthesis of N-glycans begins on the cytoplasmic face of the ER membrane with the transferase reaction of UDP-GlcNAc and the lipid-like precursor P-Dol (dolichol phosphate) to generate GlcNAc a1- PP-Dol. After sequential addition of monosaccharides by ALG glycosyltransferases [MD:M00055], the N-glycan precursor is attached by the OST (oligosaccharyltransferase) complex to the polypeptide chain that is being synthesized and translocated through the ER membrane. The protein-bound N-glycan precursor is subsequently trimmed, extended, and modified in the ER and Golgi by a complex series of reactions catalyzed by membrane-bound glycosidases and glycosyltransferases. N-glycans thus synthesized are classified into three types: high-mannose type, complex type, and hybrid type. Defects in N-glycan biosynthesis lead to a variety of human diseases known as congenital disorders of glycosylation [DS:H00118 H00119]. More...
hsa01100	Metabolic pathways	237

Genes shared at least 5 GO terms with MGAT4B (count: 8)

Gene Symbol	Pathway Count	Pathway List
B4GALT4	6	post-translational protein modification; cellular protein metabolic process; integral to membrane; protein N-linked glycosylation via asparagine; Golgi membrane; metal ion binding;
B4GALT6	6	post-translational protein modification; cellular protein metabolic process; integral to membrane; protein N-linked glycosylation via asparagine; Golgi membrane; metal ion binding;
LMAN1	6	post-translational protein modification; cellular protein metabolic process; integral to membrane; protein N-linked glycosylation via asparagine; Golgi membrane; metal ion binding;
MGAT1	6	post-translational protein modification; cellular protein metabolic process; integral to membrane; protein N-linked glycosylation via asparagine; Golgi membrane; metal ion binding;
FURIN	5	post-translational protein modification; cellular protein metabolic process; integral to membrane; Golgi membrane; metal ion binding;
MAN1A1	5	post-translational protein modification; cellular protein metabolic process; integral to membrane; protein N-linked glycosylation via asparagine; Golgi membrane;
MAN2A2	5	post-translational protein modification; cellular protein metabolic process; integral to membrane; protein N-linked glycosylation via asparagine; Golgi membrane;
ST8SIA3	5	post-translational protein modification; cellular protein metabolic process; protein N-linked glycosylation via asparagine; N-glycan processing; Golgi membrane;

Genes shared at least 2 KEGG pathways with MGAT4B (count: 10)

Gene Symbol	Pathway Count	Pathway List
ALG10	2	N-Glycan biosynthesis; Metabolic pathways;
ALG2	2	N-Glycan biosynthesis; Metabolic pathways;
ALG8	2	N-Glycan biosynthesis; Metabolic pathways;
ALG9	2	N-Glycan biosynthesis; Metabolic pathways;
DPAGT1	2	N-Glycan biosynthesis; Metabolic pathways;
GANAB	2	N-Glycan biosynthesis; Metabolic pathways;
MAN1A1	2	N-Glycan biosynthesis; Metabolic pathways;
MAN2A2	2	N-Glycan biosynthesis; Metabolic pathways;
MGAT1	2	N-Glycan biosynthesis; Metabolic pathways;
STT3A	2	N-Glycan biosynthesis; Metabolic pathways;

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Region: chr5:179224597..179233952 View in gBrowse