ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	GADD45G
Symbol Alias	DDIT2, GADD45gamma, GRP17, CR6
Approved Name	growth arrest and DNA-damage-inducible, gamma
Name Alias	gadd-related protein, 17 kD, "growth arrest and DNA-damage-inducible gamma"
Location	9q22.1-q22.2
Position	chr9:92219927-92221470, +
External Links	HGNC: 4097 Entrez Gene: 10912 Ensembl: ENSG00000130222 UCSC: uc004aqq.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
9q22	chr9:90400000-102600000	3 (1/1/1)

Gene related GO terms (count: 11)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0030154	cell differentiation	Biological Process		51
GO:0051726	regulation of cell cycle	Biological Process		8
GO:0006950	response to stress	Biological Process	TAS[9827804]	30
GO:0007275	multicellular organismal development	Biological Process		71
GO:0006915	apoptotic process	Biological Process		111
GO:0006469	negative regulation of protein kinase activity	Biological Process		13
GO:0006281	DNA repair	Biological Process	TAS[9827804]	62
GO:0005634	nucleus	Cellular Component		770
GO:0005515	protein binding	Molecular Function	IPI[15383276]	910
GO:0000186	activation of MAPKK activity	Biological Process		9
GO:0000185	activation of MAPKKK activity	Biological Process	TAS[9827804]	2

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04110	Cell cycle	19	Mitotic cell cycle progression is accomplished through a rep...... Mitotic cell cycle progression is accomplished through a reproducible sequence of events, DNA replication (S phase) and mitosis (M phase) separated temporally by gaps known as G1 and G2 phases. Cyclin-dependent kinases (CDKs) are key regulatory enzymes, each consisting of a catalytic CDK subunit and an activating cyclin subunit. CDKs regulate the cell's progression through the phases of the cell cycle by modulating the activity of key substrates. Downstream targets of CDKs include transcription factor E2F and its regulator Rb. Precise activation and inactivation of CDKs at specific points in the cell cycle are required for orderly cell division. Cyclin-CDK inhibitors (CKIs), such as p16Ink4a, p15Ink4b, p27Kip1, and p21Cip1, are involved in the negative regulation of CDK activities, thus providing a pathway through which the cell cycle is negatively regulated. More...
hsa04115	p53 signaling pathway	14	p53 activation is induced by a number of stress signals, inc...... p53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated genes. This results in three major outputs; cell cycle arrest, cellular senescence or apoptosis. Other p53-regulated gene functions communicate with adjacent cells, repair the damaged DNA or set up positive and negative feedback loops that enhance or attenuate the functions of the p53 protein and integrate these stress responses with other signal transduction pathways. More...
hsa04010	MAPK signaling pathway	69	The mitogen-activated protein kinase (MAPK) cascade is a hig...... The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli. More...

Genes shared at least 5 GO terms with GADD45G (count: 1)

Gene Symbol	Pathway Count	Pathway List
MAPK1	5	response to stress; apoptotic process; nucleus; protein binding; activation of MAPKK activity;

Genes shared at least 2 KEGG pathways with GADD45G (count: 4)

Gene Symbol	Pathway Count	Pathway List
ATM	2	Cell cycle; p53 signaling pathway;
CCND1	2	Cell cycle; p53 signaling pathway;
CDC25B	2	Cell cycle; MAPK signaling pathway;
CHEK1	2	Cell cycle; p53 signaling pathway;

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Region: chr9:92219927..92221470 View in gBrowse