Gene Report
Basic Info
Approved Symbol |
GNRHR
|
Previous Symbol |
GRHR |
Symbol Alias |
LHRHR |
Approved Name |
gonadotropin-releasing hormone receptor |
Location |
4q21.2 |
Position |
chr4:68603093-68621804, - |
External Links |
HGNC: 4421
Entrez Gene: 2798
Ensembl: ENSG00000109163
UCSC: uc003hdn.2
|
No. of Studies |
0 (significant: 0; non-significant: 0; trend: 0) |
Source |
Mapped by significant region |
Gene related studies (count: 0)
Gene related SNPs (count: 0)
Gene related CNVs (count: 0)
Gene related other variant (count: 0)
Gene related regions (count: 1)
Gene related GO terms (count: 7)
Gene related KEGG pathways (count: 2)
ID |
Name |
No. of Genes in ADHDgene |
Brief Description |
hsa04080 |
Neuroactive ligand-receptor interaction |
93 |
|
hsa04912 |
GnRH signaling pathway |
28 |
Gonadotropin-releasing hormone (GnRH) secretion from the hyp......
Gonadotropin-releasing hormone (GnRH) secretion from the hypothalamus acts upon its receptor in the anterior pituitary to regulate the production and release of the gonadotropins, LH and FSH. The GnRHR is coupled to Gq/11 proteins to activate phospholipase C which transmits its signal to diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG activates the intracellular protein kinase C (PKC) pathway and IP3 stimulates release of intracellular calcium. In addition to the classical Gq/11, coupling of Gs is occasionally observed in a cell-specific fashion. Signaling downstream of protein kinase C (PKC) leads to transactivation of the epidermal growth factor (EGF) receptor and activation of mitogen-activated protein kinases (MAPKs), including extracellular-signal-regulated kinase (ERK), Jun N-terminal kinase (JNK) and p38 MAPK. Active MAPKs translocate to the nucleus, resulting in activation of transcription factors and rapid induction of early genes.
More...
|
Genes shared at least 5 GO terms with GNRHR (count: 0)
Genes shared at least 2 KEGG pathways with GNRHR (count: 0)
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