ADHDgene Database

Gene Report

Basic Info

Approved Symbol	H2AFY
Symbol Alias	macroH2A1.2
Approved Name	H2A histone family, member Y
Location	5q31.1
Position	chr5:134669590-134735604, -
External Links	HGNC: 4740 Entrez Gene: 9555 Ensembl: ENSG00000113648 UCSC: uc003lam.1
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Hinney, A., 2011	This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08.	Non-significant

Gene related SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs2114961	Chr5:134574232(Fwd)	intron_variant; nc_transcript_variant	1(0/1/0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0003682	chromatin binding	Molecular Function		48
GO:0003677	DNA binding	Molecular Function	NAS[9714746]	220
GO:0006334	nucleosome assembly	Biological Process	NAS[9714746]	9
GO:0005515	protein binding	Molecular Function		910
GO:0016568	chromatin modification	Biological Process		16
GO:0007549	dosage compensation	Biological Process	IDA[15053874]	1
GO:0046982	protein heterodimerization activity	Molecular Function		68
GO:0000786	nucleosome	Cellular Component	NAS[9714746]	3
GO:0001740	Barr body	Cellular Component	IDA[11331621]	1
GO:0000793	condensed chromosome	Cellular Component		4

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa05322	Systemic lupus erythematosus	19	Systemic lupus erythematosus (SLE) is a prototypic autoimmun...... Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterised by the production of IgG autoantibodies that are specific for self-antigens, such as DNA, nuclear proteins and certain cytoplasmic components, in association with a diverse array of clinical manifestations. The primary pathological findings in patients with SLE are those of inflammation, vasculitis, immune complex deposition, and vasculopathy. Immune complexes comprising autoantibody and self-antigen is deposited particulary in the renal glomeruli and mediate a systemic inflammatory response by activating complement or via Fc{gamma}R-mediated neutrophil and macrophage activation. Activation of complement (C5) leads to injury both through formation of the membrane attack complex (C5b-9) or by generation of the anaphylatoxin and cell activator C5a. Neutrophils and macrophages cause tissue injury by the release of oxidants and proteases. More...

Genes shared at least 5 GO terms with H2AFY (count: 1)

Gene Symbol	Pathway Count	Pathway List
H2AFX	5	DNA binding; nucleosome assembly; protein binding; protein heterodimerization activity; nucleosome;

Genes shared at least 2 KEGG pathways with H2AFY (count: 0)

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Region: chr5:134669590..134735604 View in gBrowse