ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	IL7R
Symbol Alias	CD127
Approved Name	interleukin 7 receptor
Location	5p13
Position	chr5:35852797-35879705, +
External Links	HGNC: 6024 Entrez Gene: 3575 UCSC: uc003jjs.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
5p13	chr5:28900000-42500000	3 (1/1/1)

Gene related GO terms (count: 23)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 23)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0048872	homeostasis of number of cells	Biological Process		4
GO:0042100	B cell proliferation	Biological Process		1
GO:0048535	lymph node development	Biological Process		3
GO:0033089	positive regulation of T cell differentiation in thymus	Biological Process		4
GO:0038111	interleukin-7-mediated signaling pathway	Biological Process	TAS[8266077]	1
GO:0016049	cell growth	Biological Process		11
GO:0030217	T cell differentiation	Biological Process		5
GO:0010628	positive regulation of gene expression	Biological Process		28
GO:0016021	integral to membrane	Cellular Component		845
GO:0007166	cell surface receptor signaling pathway	Biological Process	TAS[9843216]	35
GO:0007165	signal transduction	Biological Process	TAS[2317865]	171
GO:0009897	external side of plasma membrane	Cellular Component		34
GO:0008361	regulation of cell size	Biological Process		3
GO:0005576	extracellular region	Cellular Component		240
GO:0005515	protein binding	Molecular Function	IPI[8266077]	910
GO:0006955	immune response	Biological Process	TAS[9843216]	45
GO:0005886	plasma membrane	Cellular Component		772
GO:0002377	immunoglobulin production	Biological Process		1
GO:0001915	negative regulation of T cell mediated cytotoxicity	Biological Process		1
GO:0004917	interleukin-7 receptor activity	Molecular Function	TAS[8266077]	1
GO:0003823	antigen binding	Molecular Function	TAS[9495344]	3
GO:0000902	cell morphogenesis	Biological Process		7
GO:0000018	regulation of DNA recombination	Biological Process	TAS[9495344]	1

Gene related KEGG pathways (count: 4)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04640	Hematopoietic cell lineage	13	Blood-cell development progresses from a hematopoietic stem ...... Blood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid progenitor (CLP) or a common myeloid progenitor (CMP). A CLP gives rise to the lymphoid lineage of white blood cells or leukocytes-the natural killer (NK) cells and the T and B lymphocytes. A CMP gives rise to the myeloid lineage, which comprises the rest of the leukocytes, the erythrocytes (red blood cells), and the megakaryocytes that produce platelets important in blood clotting. Cells undergoing these differentiation process express a stage- and lineage-specific set of surface markers. Therefore cellular stages are identified by the specific expression patterns of these genes. More...
hsa05340	Primary immunodeficiency	5	Primary immunodeficiencies (PIs) are a heterogeneous group o...... Primary immunodeficiencies (PIs) are a heterogeneous group of disorders, which affect cellular and humoral immunity or non-specific host defense mechanisms mediated by complement proteins, and cells such as phagocytes and natural killer (NK) cells. These disorders of the immune system cause increased susceptibility to infection, autoimmune disease, and malignancy. Most of PIs are due to genetic defects that affect cell maturation or function at different levels during hematopoiesis. Disruption of the cellular immunity is observed in patients with defects in T cells or both T and B cells. These cellular immunodeficiencies comprise 20% of all PIs. Disorders of humoral immunity affect B-cell differentiation and antibody production. They account for 70% of all PIs. More...
hsa04060	Cytokine-cytokine receptor interaction	38	Cytokines are soluble extracellular proteins or glycoprotein...... Cytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell growth, differentiation, cell death, angiogenesis, and development and repair processes aimed at the restoration of homeostasis. Cytokines are released by various cells in the body, usually in response to an activating stimulus, and they induce responses through binding to specific receptors on the cell surface of target cells. Cytokines can be grouped by structure into different families and their receptors can likewise be grouped. More...
hsa04630	Jak-STAT signaling pathway	22	The Janus kinase/signal transducers and activators of transc...... The Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeostasis in animals, from humans to flies. In mammals, the JAK/STAT pathway is the principal signaling mechanism for a wide array of cytokines and growth factors. Following the binding of cytokines to their cognate receptor, STATs are activated by members of the JAK family of tyrosine kinases. Once activated, they dimerize and translocate to the nucleus and modulate the expression of target genes. In addition to the activation of STATs, JAKs mediate the recruitment of other molecules such as the MAP kinases, PI3 kinase etc. These molecules process downstream signals via the Ras-Raf-MAP kinase and PI3 kinase pathways which results in the activation of additional transcription factors. More...

Genes shared at least 5 GO terms with IL7R (count: 6)

Gene Symbol	Pathway Count	Pathway List
ERBB2	5	integral to membrane; cell surface receptor signaling pathway; signal transduction; protein binding; plasma membrane;
FCGR2B	5	integral to membrane; signal transduction; protein binding; immune response; plasma membrane;
FCGR3A	5	integral to membrane; external side of plasma membrane; extracellular region; immune response; plasma membrane;
PVRL1	5	integral to membrane; extracellular region; protein binding; immune response; plasma membrane;
CCR5	5	cell surface receptor signaling pathway; external side of plasma membrane; protein binding; immune response; plasma membrane;
SPN	5	cell surface receptor signaling pathway; signal transduction; external side of plasma membrane; immune response; plasma membrane;

Genes shared at least 2 KEGG pathways with IL7R (count: 19)

Gene Symbol	Pathway Count	Pathway List
IL11RA	3	Hematopoietic cell lineage; Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
IL5RA	3	Hematopoietic cell lineage; Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
IL6	3	Hematopoietic cell lineage; Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
CD3D	2	Hematopoietic cell lineage; Primary immunodeficiency;
CD3E	2	Hematopoietic cell lineage; Primary immunodeficiency;
TNFRSF13B	2	Primary immunodeficiency; Cytokine-cytokine receptor interaction;
CLCF1	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
CNTF	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
CNTFR	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
CTF1	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
GHR	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
IFNGR1	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
IL10RA	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
IL12B	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
IL20RA	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
IL22RA2	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
LIFR	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
OSMR	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;
PRLR	2	Cytokine-cytokine receptor interaction; Jak-STAT signaling pathway;

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Region: chr5:35852797..35879705 View in gBrowse