ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	KCNN2
Symbol Alias	KCa2.2, hSK2
Approved Name	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2
Location	5q22.3
Position	chr5:113696666-113832321, +
External Links	HGNC: 6291 Entrez Gene: 3781 Ensembl: ENSG00000080709 UCSC: uc003kqo.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by LD-proxy

Gene related studies (count: 0)

Gene related SNPs (count: 22)

Literature-origin SNPs (count: 0)

LD-proxies (count: 22)

rs_ID	Location	Functional Annotation
rs4705669	Chr5:113823916(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs10519386	Chr5:113801979(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs4705670	Chr5:113824088(Fwd)	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant
rs337716	Chr5:113756816(Fwd)	intron_variant; nc_transcript_variant
rs337715	Chr5:113755797(Fwd)	intron_variant; nc_transcript_variant
rs17136627	Chr5:113798986(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs1813839	Chr5:113782773(Fwd)	NMD_transcript_variant; intron_variant; nc_transcript_variant
rs163306	Chr5:113710609(Fwd)	intron_variant; nc_transcript_variant
rs10068757	Chr5:113708449(Fwd)	intron_variant; nc_transcript_variant
rs36943	Chr5:113695178(Fwd)	upstream_gene_variant
rs36950	Chr5:113705469(Fwd)	intron_variant; nc_transcript_variant
rs402876	Chr5:113716075(Fwd)	intron_variant; nc_transcript_variant
rs36940	Chr5:113694408(Fwd)	upstream_gene_variant
rs36944	Chr5:113696010(Fwd)	upstream_gene_variant
rs337706	Chr5:113744455(Fwd)	intron_variant; nc_transcript_variant
rs337713	Chr5:113749739(Fwd)	intron_variant; nc_transcript_variant
rs337701	Chr5:113731423(Fwd)	intron_variant; nc_transcript_variant
rs337703	Chr5:113735420(Fwd)	intron_variant; nc_transcript_variant
rs163207	Chr5:113725710(Fwd)	intron_variant; nc_transcript_variant
rs337694	Chr5:113726402(Fwd)	intron_variant; nc_transcript_variant
rs337686	Chr5:113721449(Fwd)	intron_variant; nc_transcript_variant
rs337688	Chr5:113722991(Fwd)	intron_variant; nc_transcript_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 13)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:1901379	regulation of potassium ion transmembrane transport	Biological Process	IDA[17110593]	2
GO:0071805	potassium ion transmembrane transport	Biological Process	IDA[17110593]	1
GO:0051393	alpha-actinin binding	Molecular Function	IPI[17110593]	4
GO:0016286	small conductance calcium-activated potassium channel activity	Molecular Function	TAS[10991935]	1
GO:0030018	Z disc	Cellular Component		17
GO:0030315	T-tubule	Cellular Component		12
GO:0042803	protein homodimerization activity	Molecular Function	IPI[17110593]	113
GO:0006813	potassium ion transport	Biological Process	NAS[10991935]	11
GO:0007268	synaptic transmission	Biological Process		96
GO:0015269	calcium-activated potassium channel activity	Molecular Function	IDA[17110593]	1
GO:0016021	integral to membrane	Cellular Component	NAS[10991935]	845
GO:0005516	calmodulin binding	Molecular Function		32
GO:0005886	plasma membrane	Cellular Component		772

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04976	Bile secretion	13	Bile is a vital secretion, essential for digestion and absor...... Bile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins in the small intestine. Moreover, bile is an important route of elimination for excess cholesterol and many waste product, bilirubin, drugs and toxic compounds. Bile secretion depends on the function of membrane transport systems in hepatocytes and cholangiocytes and on the structural and functional integrity of the biliary tree. The hepatocytes generate the so-called primary bile in their canaliculi. Cholangiocytes modify the canalicular bile by secretory and reabsorptive processes as bile passes through the bile ducts. The main solutes in bile are bile acids, which stimulate bile secretion osmotically, as well as facilitate the intestinal absorption of dietary lipids by their detergent properties. Bile acids are also important signalling molecules. Through the activation of nuclear receptors, they regulate their own synthesis and transport rates. More...

Genes shared at least 5 GO terms with KCNN2 (count: 1)

Gene Symbol	Pathway Count	Pathway List
CACNA1C	6	alpha-actinin binding; Z disc; synaptic transmission; integral to membrane; calmodulin binding; plasma membrane;

Genes shared at least 2 KEGG pathways with KCNN2 (count: 0)

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Region: chr5:113696666..113832321 View in gBrowse