ADHDgene Database

Gene Report

Basic Info

Approved Symbol	MTHFD2L
Symbol Alias	MGC72244
Approved Name	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
Location	4q13.3
Position	chr4:74979891-75168816, +
External Links	HGNC: 31865 Entrez Gene: 441024 Ensembl: ENSG00000163738 UCSC: uc011cbk.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 2)

ID	Location	Size	Band	Type	Inheritance
CNV_Elia[2010]_41	chr4:75380785-75471520 (NCBI Build 35 (hg17))	90736	4q13.3	Deletion (hemizygous)	Maternal
CNV_Elia[2010]_44	chr4:75380785-75471520 (NCBI Build 35 (hg17))	90736	4q13.3	Deletion (hemizygous)	Paternal

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 14)

ID	Name	Type	No. of Genes in ADHDgene
GO:0009086	methionine biosynthetic process	Biological Process	2
GO:0009396	folic acid-containing compound biosynthetic process	Biological Process	2
GO:0035999	tetrahydrofolate interconversion	Biological Process	4
GO:0005743	mitochondrial inner membrane	Cellular Component	44
GO:0005829	cytosol	Cellular Component	447
GO:0006164	purine nucleotide biosynthetic process	Biological Process	1
GO:0006730	one-carbon metabolic process	Biological Process	9
GO:0005739	mitochondrion	Cellular Component	183
GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity	Molecular Function	1
GO:0004487	methylenetetrahydrofolate dehydrogenase (NAD+) activity	Molecular Function	1
GO:0004477	methenyltetrahydrofolate cyclohydrolase activity	Molecular Function	1
GO:0004329	formate-tetrahydrofolate ligase activity	Molecular Function	1
GO:0000166	nucleotide binding	Molecular Function	73
GO:0000105	histidine biosynthetic process	Biological Process	1

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa01100	Metabolic pathways	237
hsa00670	One carbon pool by folate	6

Genes shared at least 5 GO terms with MTHFD2L (count: 0)

Genes shared at least 2 KEGG pathways with MTHFD2L (count: 4)

Gene Symbol	Pathway Count	Pathway List
ATIC	2	Metabolic pathways; One carbon pool by folate;
MTHFR	2	Metabolic pathways; One carbon pool by folate;
SHMT1	2	Metabolic pathways; One carbon pool by folate;
SHMT2	2	Metabolic pathways; One carbon pool by folate;

View in gBrowse

Region: chr4:74979891..75168816 View in gBrowse