ADHDgene Database

Gene Report

Basic Info

Approved Symbol	NLRX1
Symbol Alias	NOD9, CLR11.3
Approved Name	NLR family member X1
Name Alias	nucleotide-binding oligomerization domain, leucine rich repeat containing X1, "NOD-like receptor X1", "NLR family, X1"
Location	11q23.3
Position	chr11:119037277-119054725, +
External Links	HGNC: 29890 Entrez Gene: 79671 Ensembl: ENSG00000160703 UCSC: uc001pvw.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 6)

ID	Name	Type	No. of Genes in ADHDgene
GO:0032480	negative regulation of type I interferon production	Biological Process	10
GO:0019048	virus-host interaction	Biological Process	54
GO:0045087	innate immune response	Biological Process	54
GO:0005515	protein binding	Molecular Function	910
GO:0005741	mitochondrial outer membrane	Cellular Component	21
GO:0005524	ATP binding	Molecular Function	228

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04622	RIG-I-like receptor signaling pathway	10	Specific families of pattern recognition receptors are respo...... Specific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular viral replication is recognized by a family of cytosolic RNA helicases termed RIG-I-like receptors (RLRs). The RLR proteins include RIG-I, MDA5, and LGP2 and are expressed in both immune and nonimmune cells. Upon recognition of viral nucleic acids, RLRs recruit specific intracellular adaptor proteins to initiate signaling pathways that lead to the synthesis of type I interferon and other inflammatory cytokines, which are important for eliminating viruses. More...

Genes shared at least 5 GO terms with NLRX1 (count: 1)

Gene Symbol	Pathway Count	Pathway List
MAVS	5	negative regulation of type I interferon production; virus-host interaction; innate immune response; protein binding; mitochondrial outer membrane;

Genes shared at least 2 KEGG pathways with NLRX1 (count: 0)

View in gBrowse

Region: chr11:119037277..119054725 View in gBrowse