Gene Report
Basic Info
Approved Symbol |
MAVS
|
Symbol Alias |
VISA, KIAA1271, IPS-1, Cardif |
Approved Name |
mitochondrial antiviral signaling protein |
Name Alias |
virus-induced signaling adaptor, "IFN-B promoter stimulator 1", "CARD adaptor inducing IFN-beta" |
Location |
20p13 |
Position |
chr20:3827449-3856762, + |
External Links |
HGNC: 29233
Entrez Gene: 57506
Ensembl: ENSG00000088888
UCSC: uc002wjw.3
|
No. of Studies |
0 (significant: 0; non-significant: 0; trend: 0) |
Source |
Mapped by CNV |
Gene related studies (count: 0)
Gene related SNPs (count: 0)
Gene related CNVs (count: 1)
Gene related other variant (count: 0)
Gene related regions (count: 0)
Gene related GO terms (count: 32)
Gene related KEGG pathways (count: 4)
ID |
Name |
No. of Genes in ADHDgene |
Brief Description |
hsa05160 |
Hepatitis C |
17 |
Hepatitis C virus (HCV) is a major cause of chronic liver di......
Hepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the cytoplasm of the host cell and forms membrane-associated replication complexes along with non-structural proteins. Viral RNA can trigger the RIG-I pathway and interferon production during this process. Translated HCV protein products regulate immune response to inhibit the action of interferon. HCV core and NS5A proteins appear to be the most important molecules with regulatory functions that modulate transcription, cellular proliferation, and apoptosis.
More...
|
hsa04622 |
RIG-I-like receptor signaling pathway |
10 |
Specific families of pattern recognition receptors are respo......
Specific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular viral replication is recognized by a family of cytosolic RNA helicases termed RIG-I-like receptors (RLRs). The RLR proteins include RIG-I, MDA5, and LGP2 and are expressed in both immune and nonimmune cells. Upon recognition of viral nucleic acids, RLRs recruit specific intracellular adaptor proteins to initiate signaling pathways that lead to the synthesis of type I interferon and other inflammatory cytokines, which are important for eliminating viruses.
More...
|
hsa04623 |
Cytosolic DNA-sensing pathway |
9 |
Specific families of pattern recognition receptors are respo......
Specific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified sensor of cytosolic DNA which activates the IRF and NF-{kappa}B transcription factors, leading to production of type I interferon and other cytokines. The second type of cytoplasmic DNA sensor is AIM2. Upon sensing DNA, AIM2 triggers the assembly of the inflammasome, culminating in interleukin maturation. In addition to these receptors, there is a mechanism to sense foreign DNA, with the host RNA polymerase III converting the DNA into RNA for recognition by the RNA sensor RIG-I. These pathways provide various means to alert the cell.
More...
|
hsa05162 |
Measles |
20 |
Measles virus (MV) is highly contagious virus that leads inf......
Measles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacterial infections. Several MV proteins have been suggested to disturb host immunity. After infection of host lymphoid cells via SLAM, MV inhibits cytokine response by direct interference with host signaling systems. Three proteins (P, V, and C) associate with Jak/STAT proteins in interferon-triggered pathway and other important proteins related to apoptosis. Interaction between MV and host brings about the shift towards a Th2 response by decreasing IL-12 production and induces lymphopenia by suppressing cell proliferation.
More...
|
Genes shared at least 5 GO terms with MAVS (count: 18)
Genes shared at least 2 KEGG pathways with MAVS (count: 9)
View in gBrowse