ADHDgene Database

Gene Report

Basic Info

Approved Symbol	SIGLEC1
Previous Symbol	SN
Symbol Alias	SIGLEC-1, CD169, FLJ00051, FLJ00055, FLJ00073, FLJ32150, dJ1009E24.1, sialoadhesin
Approved Name	sialic acid binding Ig-like lectin 1, sialoadhesin
Previous Name	sialoadhesin
Location	20p13
Position	chr20:3667617-3687775, -
External Links	HGNC: 11127 Entrez Gene: 6614 Ensembl: ENSG00000088827 UCSC: uc002wja.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Williams[2010]_35	chr20:3036010-3839896 (NCBI Build 36.1 (hg18))	803887	20p13	Loss	De novo

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 8)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0016021	integral to membrane	Cellular Component	NAS[11133773]	845
GO:0016337	cell-cell adhesion	Biological Process	NAS[11133773]	13
GO:0006954	inflammatory response	Biological Process	NAS[11133773]	51
GO:0007160	cell-matrix adhesion	Biological Process	NAS[11133773]	13
GO:0005886	plasma membrane	Cellular Component		772
GO:0006897	endocytosis	Biological Process		23
GO:0005576	extracellular region	Cellular Component		240
GO:0030246	carbohydrate binding	Molecular Function	NAS[11133773]	28

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04514	Cell adhesion molecules (CAMs)	20	Cell adhesion molecules are (glyco)proteins expressed on the...... Cell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes. More...

Genes shared at least 5 GO terms with SIGLEC1 (count: 0)

Genes shared at least 2 KEGG pathways with SIGLEC1 (count: 0)

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Region: chr20:3667617..3687775 View in gBrowse