ADHDgene Database

Gene Report

Basic Info

Approved Symbol	SLIT1
Previous Symbol	SLIL1
Symbol Alias	slit1, MEGF4, Slit-1, SLIT3
Approved Name	slit homolog 1 (Drosophila)
Previous Name	slit (Drosophila) homolog 1
Location	10q23.3-q24
Position	chr10:98757795-98945683, -
External Links	HGNC: 11085 Entrez Gene: 6585 Ensembl: ENSG00000187122 UCSC: uc001kmw.2
No. of Studies	1 (significant: 0; non-significant: 0; trend: 1)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Stergiakouli E., 2012	One of the top 20 independent SNPs with P=0.0000274 locates intronic relative to this gene.	Trend

Gene related SNPs (count: 16)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs2636788	Chr10:98876941(Fwd)	intron_variant	1(0/0/1)

rs_ID	Location	Functional Annotation
rs2817692	Chr10:98865286(Fwd)	downstream_gene_variant; intron_variant; upstream_gene_variant
rs2636815	Chr10:98878381(Fwd)	intron_variant
rs12782356	Chr10:98852893(Fwd)	intron_variant; nc_transcript_variant
rs17112401	Chr10:98855465(Fwd)	intron_variant; nc_transcript_variant
rs2817695	Chr10:98869388(Fwd)	intron_variant
rs2451766	Chr10:98874061(Fwd)	intron_variant
rs2636785	Chr10:98875129(Fwd)	intron_variant
rs2636789	Chr10:98877443(Fwd)	intron_variant
rs2817702	Chr10:98875936(Fwd)	intron_variant
rs2817696	Chr10:98869642(Fwd)	intron_variant
rs2636814	Chr10:98878091(Fwd)	intron_variant
rs2817698	Chr10:98871605(Fwd)	intron_variant
rs2636781	Chr10:98871276(Fwd)	intron_variant
rs2636783	Chr10:98872422(Fwd)	intron_variant
rs2636782	Chr10:98872134(Fwd)	intron_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 17)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005509	calcium ion binding	Molecular Function	NAS[9813312]	124
GO:0005615	extracellular space	Cellular Component	NAS[9813312]	126
GO:0005737	cytoplasm	Cellular Component		690
GO:0007411	axon guidance	Biological Process	IDA[11748139]	65
GO:0008045	motor neuron axon guidance	Biological Process	IMP[16162649]	7
GO:0021510	spinal cord development	Biological Process		1
GO:0021834	chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration	Biological Process	IDA[11748139]	1
GO:0031290	retinal ganglion cell axon guidance	Biological Process		3
GO:0033563	dorsal/ventral axon guidance	Biological Process		1
GO:0040023	establishment of nucleus localization	Biological Process		1
GO:0043395	heparan sulfate proteoglycan binding	Molecular Function		3
GO:0048495	Roundabout binding	Molecular Function	IPI[15207848]	2
GO:0048843	negative regulation of axon extension involved in axon guidance	Biological Process		1
GO:0048846	axon extension involved in axon guidance	Biological Process	IDA[16840550]	3
GO:0048853	forebrain morphogenesis	Biological Process	NAS[9813312]	2
GO:0051964	negative regulation of synapse assembly	Biological Process		2
GO:0050919	negative chemotaxis	Biological Process	IDA[11748139]	1

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04360	Axon guidance	25	Axon guidance represents a key stage in the formation of neu...... Axon guidance represents a key stage in the formation of neuronal network. Axons are guided by a variety of guidance factors, such as netrins, ephrins, Slits, and semaphorins. These guidance cues are read by growth cone receptors, and signal transduction pathways downstream of these receptors converge onto the Rho GTPases to elicit changes in cytoskeletal organization that determine which way the growth cone will turn. More...

Genes shared at least 5 GO terms with SLIT1 (count: 0)

Genes shared at least 2 KEGG pathways with SLIT1 (count: 0)

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Region: chr10:98757795..98945683 View in gBrowse