Gene Report
Basic Info
Approved Symbol |
STIP1
|
Symbol Alias |
HOP, STI1 |
Approved Name |
stress-induced-phosphoprotein 1 |
Name Alias |
Hsp70/Hsp90-organizing protein |
Location |
11q13 |
Position |
chr11:63953297-63972020, + |
External Links |
HGNC: 11387
Entrez Gene: 10963
Ensembl: ENSG00000168439
UCSC: uc001nyk.1
|
No. of Studies |
0 (significant: 0; non-significant: 0; trend: 0) |
Source |
Mapped by significant region |
Gene related studies (count: 0)
Gene related SNPs (count: 0)
Gene related CNVs (count: 0)
Gene related other variant (count: 0)
Gene related regions (count: 1)
Gene related GO terms (count: 9)
Gene related KEGG pathways (count: 1)
ID |
Name |
No. of Genes in ADHDgene |
Brief Description |
hsa05020 |
Prion diseases |
11 |
Prion diseases, also termed transmissible spongiform encepha......
Prion diseases, also termed transmissible spongiform encephalopathies (TSEs), are a group of fatal neurodegenerative diseases that affect humans and a number of other animal species. The etiology of these diseases is thought to be associated with the conversion of a normal protein, PrPC, into an infectious, pathogenic form, PrPSc. The conversion is induced by prion infections (for example, variant Creutzfeldt-Jakob disease (vCJD), iatrogenic CJD, Kuru), mutations (familial CJD, Gerstmann-Straussler-Scheinker syndrome, fatal familial insomnia (FFI)) or unknown factors (sporadic CJD (sCJD)), and is thought to occur after PrPC has reached the plasma membrane or is re-internalized for degradation. The PrPSc form shows greater protease resistance than PrPC and accumulates in affected individuals, often in the form of extracellular plaques. Pathways that may lead to neuronal death comprise oxidative stress, regulated activation of complement, ubiquitin-proteasome and endosomal-lysosomal systems, synaptic alterations and dendritic atrophy, corticosteroid response, and endoplasmic reticulum stress. In addition, the conformational transition could lead to the lost of a beneficial activity of the natively folded protein, PrPC.
More...
|
Genes shared at least 5 GO terms with STIP1 (count: 1)
Genes shared at least 2 KEGG pathways with STIP1 (count: 0)
View in gBrowse