ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	TGFB1I1
Symbol Alias	Hic-5, TSC-5, ARA55, HIC-5
Approved Name	transforming growth factor beta 1 induced transcript 1
Location	16p11
Position	chr16:31483394-31489281, +
External Links	HGNC: 11767 Entrez Gene: 7041 Ensembl: ENSG00000140682 UCSC: uc002ecd.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by PBA pathway

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 28)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0035257	nuclear hormone receptor binding	Molecular Function		30

GO terms by database search (count: 27)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0016055	Wnt receptor signaling pathway	Biological Process		20
GO:0016331	morphogenesis of embryonic epithelium	Biological Process		1
GO:0009408	response to heat	Biological Process		7
GO:0010718	positive regulation of epithelial to mesenchymal transition	Biological Process	IDA[18762808]	3
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	Biological Process	IDA[18762808]	13
GO:0030521	androgen receptor signaling pathway	Biological Process	NAS[15572661]	16
GO:0016363	nuclear matrix	Cellular Component		16
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway	Biological Process	IDA[18762808]	6
GO:0031012	extracellular matrix	Cellular Component		28
GO:0030579	ubiquitin-dependent SMAD protein catabolic process	Biological Process	IDA[18762808]	1
GO:0030855	epithelial cell differentiation	Biological Process		7
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	IDA[10075738]; NAS[15572661]	80
GO:0048495	Roundabout binding	Molecular Function	IPI[19855388]	2
GO:0045165	cell fate commitment	Biological Process		4
GO:0045599	negative regulation of fat cell differentiation	Biological Process		5
GO:0070411	I-SMAD binding	Molecular Function	IPI[18762808]	2
GO:0050681	androgen receptor binding	Molecular Function	IPI[10075738]; NAS[15572661]	10
GO:0005515	protein binding	Molecular Function	IPI[10604475]	910
GO:0003713	transcription coactivator activity	Molecular Function	IDA[10075738]; NAS[15572661]	52
GO:0005737	cytoplasm	Cellular Component		690
GO:0005622	intracellular	Cellular Component	IDA[10075738]	67
GO:0005925	focal adhesion	Cellular Component		26
GO:0005856	cytoskeleton	Cellular Component		54
GO:0007155	cell adhesion	Biological Process	TAS[9422762]	86
GO:0006366	transcription from RNA polymerase II promoter	Biological Process	TAS[10075738]	62
GO:0008285	negative regulation of cell proliferation	Biological Process	TAS[7929412]	59
GO:0008270	zinc ion binding	Molecular Function		323

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with TGFB1I1 (count: 18)

Gene Symbol	Pathway Count	Pathway List
NRIP1	6	androgen receptor signaling pathway; nuclear hormone receptor binding; positive regulation of transcription, DNA-dependent; androgen receptor binding; protein binding; transcription coactivator activity;
RAN	6	androgen receptor signaling pathway; positive regulation of transcription, DNA-dependent; androgen receptor binding; protein binding; transcription coactivator activity; cytoplasm;
ADAM17	6	positive regulation of transforming growth factor beta receptor signaling pathway; protein binding; cytoplasm; focal adhesion; cell adhesion; zinc ion binding;
TFAP2A	6	positive regulation of transcription, DNA-dependent; protein binding; transcription coactivator activity; cytoplasm; transcription from RNA polymerase II promoter; negative regulation of cell proliferation;
DAB2	5	Wnt receptor signaling pathway; positive regulation of epithelial to mesenchymal transition; positive regulation of transforming growth factor beta receptor signaling pathway; positive regulation of transcription, DNA-dependent; protein binding;
DAXX	5	androgen receptor signaling pathway; nuclear hormone receptor binding; androgen receptor binding; protein binding; cytoplasm;
KAT5	5	androgen receptor signaling pathway; positive regulation of transcription, DNA-dependent; androgen receptor binding; protein binding; transcription coactivator activity;
MED1	5	androgen receptor signaling pathway; nuclear hormone receptor binding; positive regulation of transcription, DNA-dependent; protein binding; transcription coactivator activity;
MED16	5	androgen receptor signaling pathway; nuclear hormone receptor binding; positive regulation of transcription, DNA-dependent; transcription coactivator activity; transcription from RNA polymerase II promoter;
MED4	5	androgen receptor signaling pathway; nuclear hormone receptor binding; positive regulation of transcription, DNA-dependent; protein binding; transcription from RNA polymerase II promoter;
THRAP3	5	androgen receptor signaling pathway; nuclear hormone receptor binding; positive regulation of transcription, DNA-dependent; protein binding; transcription coactivator activity;
MEN1	5	nuclear matrix; positive regulation of transforming growth factor beta receptor signaling pathway; protein binding; cytoplasm; negative regulation of cell proliferation;
SNW1	5	nuclear matrix; positive regulation of transforming growth factor beta receptor signaling pathway; nuclear hormone receptor binding; protein binding; transcription coactivator activity;
MMS19	5	nuclear hormone receptor binding; positive regulation of transcription, DNA-dependent; protein binding; transcription coactivator activity; cytoplasm;
NUP62	5	nuclear hormone receptor binding; positive regulation of transcription, DNA-dependent; protein binding; cytoplasm; negative regulation of cell proliferation;
SMARCD3	5	nuclear hormone receptor binding; positive regulation of transcription, DNA-dependent; protein binding; transcription coactivator activity; cytoplasm;
MAPK1	5	positive regulation of transcription, DNA-dependent; protein binding; cytoplasm; focal adhesion; cytoskeleton;
LPXN	5	protein binding; cytoplasm; focal adhesion; cell adhesion; zinc ion binding;

Genes shared at least 2 KEGG pathways with TGFB1I1 (count: 0)

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Region: chr16:31483394..31489281 View in gBrowse