ADHDgene Database

Gene Report

Basic Info

Approved Symbol	TOP3A
Previous Symbol	TOP3
Approved Name	topoisomerase (DNA) III alpha
Location	17p12-p11.2
Position	chr17:18174742-18218321, -
External Links	HGNC: 11992 Entrez Gene: 7156 Ensembl: ENSG00000177302 UCSC: uc002gsx.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
17p11	chr17:16000000-24000000	3 (2/0/1)

Gene related GO terms (count: 10)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0016605	PML body	Cellular Component	IDA[10728666]	10
GO:0008270	zinc ion binding	Molecular Function		323
GO:0005694	chromosome	Cellular Component		15
GO:0005634	nucleus	Cellular Component	TAS[8622991]	770
GO:0007126	meiosis	Biological Process	TAS[8622991]	11
GO:0006265	DNA topological change	Biological Process		2
GO:0003917	DNA topoisomerase type I activity	Molecular Function		2
GO:0003677	DNA binding	Molecular Function	TAS[8622991]	220
GO:0005524	ATP binding	Molecular Function		228
GO:0005515	protein binding	Molecular Function	IPI[10728666]	910

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03440	Homologous recombination	7	Homologous recombination (HR) is essential for the accurate ...... Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR. More...

Genes shared at least 5 GO terms with TOP3A (count: 4)

Gene Symbol	Pathway Count	Pathway List
ZBTB16	5	PML body; zinc ion binding; nucleus; DNA binding; protein binding;
IGHMBP2	5	zinc ion binding; nucleus; DNA binding; ATP binding; protein binding;
ZFR	5	zinc ion binding; chromosome; nucleus; DNA binding; protein binding;
TOP3B	5	nucleus; DNA topological change; DNA topoisomerase type I activity; DNA binding; ATP binding;

Genes shared at least 2 KEGG pathways with TOP3A (count: 0)

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Region: chr17:18174742..18218321 View in gBrowse