ADHDgene Database

Gene Report

Basic Info

Approved Symbol	TOP3B
Approved Name	topoisomerase (DNA) III beta
Location	22q11.22
Position	chr22:22309947-22337213, -
External Links	HGNC: 11993 Entrez Gene: 8940 Ensembl: ENSG00000100038 UCSC: uc002zvs.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 0)

Gene related SNPs (count: 3)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs412050	Chr22:22307519(Fwd)	downstream_gene_variant; upstream_gene_variant	1(0/0/1)

rs_ID	Location	Functional Annotation
rs239915	Chr22:22316631(Fwd)	3_prime_UTR_variant; NMD_transcript_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant
rs239914	Chr22:22317337(Fwd)	NMD_transcript_variant; intron_variant; synonymous_variant; upstream_gene_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 8)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0003677	DNA binding	Molecular Function	TAS[9786843]	220
GO:0000793	condensed chromosome	Cellular Component		4
GO:0006265	DNA topological change	Biological Process		2
GO:0007059	chromosome segregation	Biological Process		14
GO:0005524	ATP binding	Molecular Function		228
GO:0005634	nucleus	Cellular Component	TAS[9786843]	770
GO:0003916	DNA topoisomerase activity	Molecular Function	TAS[9786843]	1
GO:0003917	DNA topoisomerase type I activity	Molecular Function		2

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa03440	Homologous recombination	7	Homologous recombination (HR) is essential for the accurate ...... Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR. More...

Genes shared at least 5 GO terms with TOP3B (count: 1)

Gene Symbol	Pathway Count	Pathway List
TOP3A	5	DNA binding; DNA topological change; ATP binding; nucleus; DNA topoisomerase type I activity;

Genes shared at least 2 KEGG pathways with TOP3B (count: 0)

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Region: chr22:22309947..22337213 View in gBrowse