ADHDgene Database

SNP Report

Basic Info

Name	rs4686673 dbSNP Ensembl
Location	Chr3:193861242(Fwd)
Variant Alleles	C/T
Ancestral Allele	T
Functional Annotation	downstream_gene_variant; upstream_gene_variant.
Consequence to Transcript	downstream_gene_variant(ENST00000232424) upstream_gene_variant(ENST00000487718)
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Brookes K, 2006	A/G		UNPHASED TDT P-value=0.016; WHAP TDT P-value=0.052 UNPHASED TDT P-value=0.016; WHAP TDT P-value=0.052	significant association was observed in UNPHASED analysis significant association was observed in UNPHASED analysis	Significant

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
HES1	hairy and enhancer of split 1, (Drosophila)	3q28-q29	1(1/0/0)

SNPs in LD with rs4686673 (count: 5) View in gBrowse (chr3:193854961..193867433 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

rs_ID	Functional Annotation	r²[population]
rs6805836	downstream_gene_variant	0.908[CEU]; 0.953[CHB]; 0.932[CHD]; 0.822[JPT]; 0.949[MEX]; 0.88[TSI]
rs6768674	downstream_gene_variant	1.0[ASW]; 1.0[CEU]; 1.0[CHB]; 1.0[CHD]; 1.0[GIH]; 1.0[JPT]; 1.0[LWK]; 1.0[MEX]; 1.0[MKK]; 1.0[TSI]; 1.0[YRI]
rs2368048	intron_variant; nc_transcript_variant; non_coding_exon_variant	0.833[CEU]; 0.826[JPT]
rs4687526	downstream_gene_variant	1.0[CEU]; 0.928[YRI]
rs4687525	downstream_gene_variant	0.821[CEU]