ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

SNP Report

Basic Info

Name	rs6323 dbSNP Ensembl
Location	ChrX:43591036(Fwd)
Variant Alleles	G/T
Ancestral Allele	T
Functional Annotation	downstream_gene_variant; synonymous_variant.
Consequence to Transcript	downstream_gene_variant(ENST00000497485) synonymous_variant(ENST00000338702; ENST00000542639)
No. of Studies	3 (significant: 0; non-significant: 3; trend: 0)
Source	Literature-origin

SNP related studies (count: 3)

Reference	Allele Change	Statistical Values	Author Comments	Result of Statistical Analysis
Ilott NE, 2010		QTDT AW P-value=0.31, X²=1.03, df=1 at age 2; QTD...... QTDT AW P-value=0.31, X²=1.03, df=1 at age 2; QTDT AW P-value=0.83, X²=0.97, df=1 at age 3 More...	no significant association no significant association	Non-significant
Hawi, Z., 2012	T:G	P-value=1, X²=0, OR=1, 95% CI=0.61-1.65 P-value=1, X²=0, OR=1, 95% CI=0.61-1.65	The marker did not show significant association with ADHD. The marker did not show significant association with ADHD.	Non-significant
Das M, 2011	G/T	ETDT P-value=0.35, X²(1df)=0.86, RR=1; allelic fr...... ETDT P-value=0.35, X²(1df)=0.86, RR=1; allelic frequencies COCAPHASE P-value=0.82, X²=0.05 for G; ETDT P-value=0.35, X²(1df)=0.86, RR=1.33; allelic frequencies COCAPHASE P-value=0.82, X²=0.05 for T More...	frequency of G allele was higher in both cases and controls ...... frequency of G allele was higher in both cases and controls as compared to the T; familial analysis revealed a mild bias in T allele transmission More...	Non-significant

SNP related genes (count: 1)

Literature-origin genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
MAOA	monoamine oxidase A	Xp11.4-p11.3	20(13/7/0)

Genes from other sources (count: 0)

SNPs in LD with rs6323 (count: 79) View in gBrowse (chrX:43420059..43612708 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

Literature-origin SNPs (count: 18)

rs_ID	Functional Annotation	#studies(significant/non-significant/trend)	r²[population]

rs2239448	intron_variant; upstream_gene_variant	3(3/0/0)	0.935[CEU]; 0.931[CHB]; 0.873[JPT]
rs1137070	nc_transcript_variant; non_coding_exon_variant; synonymous_variant	4(3/1/0)	0.935[CEU]; 0.931[CHB]; 0.967[CHD]; 0.907[GIH]; 0.873[JPT]; 0.965[TSI]
rs5905859	downstream_gene_variant; intron_variant	2(2/0/0)	1.0[CHB]; 1.0[CHD]; 0.933[JPT]; 0.824[MEX]; 0.927[TSI]
rs2235185	intron_variant	1(1/0/0)	1.0[ASW]; 1.0[CEU]; 1.0[CHB]; 0.967[CHD]; 1.0[GIH]; 1.0[JPT]; 1.0[LWK]; 1.0[MEX]; 1.0[MKK]; 1.0[TSI]; 1.0[YRI]
rs2205718	intron_variant	1(0/1/0)	1.0[ASW]; 1.0[CEU]; 1.0[CHB]; 0.967[CHD]; 1.0[GIH]; 1.0[JPT]; 1.0[LWK]; 0.871[MEX]; 1.0[MKK]; 1.0[TSI]; 0.877[YRI]
rs3027407	3_prime_UTR_variant; downstream_gene_variant	3(2/1/0)	0.935[CEU]; 0.931[CHB]; 1.0[JPT]
rs4570308	upstream_gene_variant	1(1/0/0)	0.877[CEU]; 0.858[CHB]; 0.869[JPT]
rs2283724	intron_variant; nc_transcript_variant	1(0/1/0)	0.858[CHB]; 0.935[CHD]; 0.933[JPT]
rs979605	intron_variant; upstream_gene_variant	2(0/2/0)	1.0[CEU]; 1.0[CHB]; 0.967[CHD]; 1.0[GIH]; 0.873[JPT]; 0.936[MEX]; 1.0[TSI]
rs2072744	intron_variant; upstream_gene_variant	1(1/0/0)	1.0[CHB]; 1.0[JPT]
rs3788862	intron_variant; nc_transcript_variant	1(1/0/0)	0.858[CHB]; 0.869[JPT]
rs5953210	upstream_gene_variant	1(1/0/0)	0.877[CEU]; 0.858[CHB]; 0.872[CHD]; 0.84[GIH]; 0.869[JPT]; 0.809[MEX]
rs5905702	intron_variant; nc_transcript_variant	1(0/1/0)	0.876[CEU]; 0.858[CHB]; 0.871[CHD]; 0.84[GIH]; 0.869[JPT]
rs3027400	downstream_gene_variant; intron_variant	3(3/0/0)	1.0[ASW]; 1.0[CEU]; 1.0[CHB]; 0.967[CHD]; 1.0[GIH]; 1.0[JPT]; 1.0[LWK]; 1.0[MEX]; 1.0[MKK]; 1.0[TSI]; 1.0[YRI]
rs3788863	intron_variant; nc_transcript_variant	1(1/0/0)	0.877[CEU]; 0.858[CHB]; 0.872[CHD]; 0.872[GIH]; 0.933[JPT]; 0.809[MEX]
rs6610845	intron_variant; nc_transcript_variant	1(0/1/0)	1.0[CHB]; 1.0[CHD]; 1.0[JPT]; 0.824[MEX]; 0.932[TSI]
rs12843268	intron_variant; nc_transcript_variant	3(2/1/0)	1.0[CEU]; 1.0[CHB]; 0.967[CHD]; 0.936[GIH]; 1.0[JPT]; 0.824[MEX]; 1.0[TSI]
rs2235186	downstream_gene_variant; intron_variant	1(1/0/0)	1.0[ASW]; 1.0[CEU]; 1.0[CHB]; 0.967[CHD]; 1.0[GIH]; 1.0[JPT]; 1.0[LWK]; 1.0[MEX]; 1.0[MKK]; 1.0[TSI]; 1.0[YRI]

LD-proxies (count: 61)

rs_ID	Functional Annotation	r²[population]
rs1339776		0.823[CEU]
rs4986545		0.823[CEU]
rs5953385	intron_variant; nc_transcript_variant	0.877[CEU]; 0.858[CHB]; 0.872[CHD]; 0.872[GIH]; 0.933[JPT]
rs2000019		0.823[CEU]
rs4986551		0.823[CEU]
rs5906957	intron_variant; nc_transcript_variant	0.858[CHB]; 0.933[JPT]
rs3027398	intron_variant; nc_transcript_variant	0.858[CHB]; 0.935[CHD]; 0.933[JPT]
rs1465107	intron_variant; nc_transcript_variant	0.858[CHB]; 0.932[JPT]
rs4986548		0.823[CEU]
rs5906898		0.823[CEU]
rs2283725	intron_variant; nc_transcript_variant	0.858[CHB]; 0.935[CHD]; 0.933[JPT]
rs4986516		0.866[CEU]
rs3027401	downstream_gene_variant; intron_variant	1.0[ASW]; 1.0[CEU]; 1.0[CHB]; 0.967[CHD]; 1.0[GIH]; 1.0[JPT]; 1.0[LWK]; 1.0[MEX]; 1.0[MKK]; 1.0[TSI]; 1.0[YRI]
rs6609257		0.806[CHD]
rs4239988		0.822[CEU]
rs4986546		0.823[CEU]
rs5991694		0.823[CEU]
rs2064070	downstream_gene_variant	0.935[CEU]; 0.931[CHB]; 0.967[CHD]; 0.907[GIH]; 0.873[JPT]; 0.964[TSI]
rs1538642		0.823[CEU]
rs4824392		0.823[CEU]
rs1339779		0.823[CEU]
rs5951054		0.823[CEU]
rs5906974	intron_variant; nc_transcript_variant	0.935[CEU]; 0.858[CHB]; 0.933[JPT]
rs929094		0.823[CEU]
rs28401570	intron_variant; nc_transcript_variant	1.0[ASW]; 1.0[CEU]; 1.0[CHB]; 1.0[CHD]; 1.0[GIH]; 1.0[JPT]; 1.0[LWK]; 1.0[MEX]; 1.0[MKK]; 1.0[TSI]; 1.0[YRI]
rs5951043		0.823[CEU]
rs2310820		0.877[CEU]
rs6610846	intron_variant; nc_transcript_variant	1.0[CHB]; 1.0[CHD]; 1.0[JPT]; 0.824[MEX]; 0.931[TSI]
rs5951044		0.823[CEU]
rs4986550		0.823[CEU]
rs28556796	intron_variant; nc_transcript_variant	1.0[ASW]; 1.0[CEU]; 1.0[CHB]; 1.0[CHD]; 1.0[GIH]; 1.0[JPT]; 1.0[LWK]; 1.0[MEX]; 1.0[MKK]; 1.0[TSI]; 1.0[YRI]
rs5951049		0.823[CEU]
rs5906261		0.877[CEU]
rs6520894	intron_variant; nc_transcript_variant	0.877[CEU]; 0.858[CHB]; 0.872[CHD]; 0.872[GIH]; 0.933[JPT]; 0.809[MEX]
rs5905613		0.877[CEU]
rs12558025		0.877[CEU]
rs1800659	intron_variant; nc_transcript_variant	0.935[CEU]; 1.0[CHB]; 0.967[CHD]; 0.936[GIH]; 1.0[JPT]; 0.824[MEX]; 0.932[TSI]
rs4083948		0.823[CEU]
rs4301558	upstream_gene_variant	0.877[CEU]; 0.858[CHB]; 0.869[JPT]
rs5906938	intron_variant; nc_transcript_variant	0.877[CEU]; 0.858[CHB]; 0.872[CHD]; 0.872[GIH]; 0.933[JPT]
rs909525	intron_variant; nc_transcript_variant	0.858[CHB]; 0.872[CHD]; 0.933[JPT]
rs6610813		0.823[CEU]
rs5951048		0.817[CEU]
rs1465108	intron_variant; nc_transcript_variant	0.876[CEU]; 0.858[CHB]; 0.868[CHD]; 0.872[GIH]; 0.933[JPT]
rs3027396	intron_variant; nc_transcript_variant	0.858[CHB]; 0.934[CHD]; 0.931[JPT]
rs3027410	downstream_gene_variant	0.93[CEU]; 0.931[CHB]; 0.967[CHD]; 0.906[GIH]; 0.873[JPT]; 0.964[TSI]
rs3810709	intron_variant; nc_transcript_variant	1.0[CHB]; 1.0[CHD]; 1.0[JPT]; 0.819[MEX]; 0.931[TSI]
rs5951055		0.823[CEU]
rs2072743	intron_variant; upstream_gene_variant	1.0[CHB]; 0.967[CHD]; 1.0[JPT]; 0.824[MEX]; 0.931[TSI]
rs6610814		0.823[CEU]
rs5906883	intron_variant; nc_transcript_variant	0.877[CEU]; 0.872[CHD]; 0.872[GIH]; 0.933[JPT]
rs979606	intron_variant; upstream_gene_variant	1.0[ASW]; 1.0[CEU]; 1.0[CHB]; 0.967[CHD]; 1.0[GIH]; 0.873[JPT]; 1.0[LWK]; 1.0[MEX]; 1.0[MKK]; 1.0[TSI]; 1.0[YRI]
rs6610823		0.823[CEU]
rs5906893	intron_variant; nc_transcript_variant	0.877[CEU]; 0.857[CHB]; 0.872[CHD]; 0.872[GIH]; 0.933[JPT]
rs1339777		0.823[CEU]
rs3027397	intron_variant; nc_transcript_variant	0.858[CHB]; 0.933[JPT]
rs3859958		0.877[CEU]
rs5906154		0.877[CEU]
rs5906729	intron_variant; nc_transcript_variant	0.877[CEU]; 0.858[CHB]; 0.933[JPT]
rs3859959		0.81[CEU]
rs1339778		0.809[CEU]