ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Study Report

Basic Info

Reference	Cho SC, 2010(b)20576502
Citation	Cho S. C., Kim H. W., Kim B. N., Kim J. W., Shin M. S., Cho D. Y., Chung S., Jung S. W., Yoo H. J., Chung I. W., Chung U. S. and Son J. W. (2010) "Neurotrophin-3 gene, intelligence, and selective attention deficit in a Korean sample with attention-deficit/hyperactivity disorder." Prog Neuropsychopharmacol Biol Psychiatry, 34(6): 1065-9.
Study Design	case-control and family-based
Study Type	Candidate-gene association study
Sample Size	202 cases, 159 controls, 151 trios
Predominant Ethnicity	Mongoloid
Population	Korea
Gender	174 ADHD subjects (86.1%) and 111 controls (69.8%) were boys
Age Group	Children/Adolescents : mean age=9.0,SD=2.5

Detail Info

Summary	They investigated the relationships between ADHD and NTF3 gene polymorphism. They conducted a case-control analysis of 202 ADHD subjects and 159 controls, performed a transmission disequilibrium test (TDT) on 151 trios, and compared the intelligence quotient (IQ) and a continuous performance test (CPT) according to the genotype of two single-nucleotide polymorphisms (SNPs) (rs6332 and rs6489630) in the NTF3 gene. In the case-control and family-based analyses, NTF3 was not significantly associated with ADHD. However, in the ADHD probands, the subjects with AA genotype in the rs6332 SNP had significantly higher mean T-scores for commission errors on the CPT than did those with the AG genotypes (P-value=0.045). The mean IQ of the ADHD probands who had the CC genotype of the rs6489630 SNP were higher compared with those who had the CT or TT genotype (P-value=0.035). The mean T-score for response time on the CPT was higher in the subjects with TT genotype in the rs6489630 SNP compared to those with the CC or CT genotype, even after adjusting for the effect of IQ (P-value=0.021). These results provide preliminary evidence of an association between NTF3 and the intelligence and selective attention deficit in the Korean population.
Total Sample	The case-control analysis included 202 ADHD subjects with a mean age of 9.0(SD=2.5) years and 159 controls with a mean age 9.0(SD=2.7) years. The family-based analysis included 151 trios consisting of an affected subject and his or her biological father and mother.
Sample Collection	ethnically Korean
Diagnosis Description	All subjects with ADHD met the following inclusion criteria: (1) DSM-IV diagnosis of ADHD; (2) above the 90th percentile in the ADHD Rating Scale-IV (ARS); (3) T-scores greater than 60 on the attention problems profile of the Child Behavior Checklist (CBCL); and (4) intelligent quotient (IQ) higher than 71 on the Korean Educational Developmental Institute's Wechsler Intelligence Scale for Children (KEDIWISC).
Technique	The detection of a SNP was based on analysis of primer extension products generated from previously amplified genomic DNA using a chip-based MALDI-TOF mass spectrometry platform. All primers in the PCR and hME reactions were designed using Assay Designer 3.1.
Analysis Method	tested the family-based and case-control associations for each individual polymorphism and haplotype using the standard TDT method in Haploview or SNPAlyzer software version 7.0. Group differences in the clinical variables for the continuous data were computed using analysis of variance (ANOVA) or analysis of covariance (ANCOVA). When the comparison was significant, a post hoc Bonferroni test was performed to evaluate the differences between the groups. The analysis was conducted using SPSS statistical software (v. 15.0).
Result Description	In the case-control and family-based analyses, NTF3 was not significantly associated with ADHD. However, in the ADHD probands, the subjects with AA genotype in the rs6332 SNP had significantly higher mean T-scores for commission errors on the CPT than did those with the AG genotypes (P-value=0.045). The mean IQ of the ADHD probands who had the CC genotype of the rs6489630 SNP were higher compared with those who had the CT or TT genotype (P-value=0.035). The mean T-score for response time on the CPT was higher in the subjects with TT genotype in the rs6489630 SNP compared to those with the CC or CT genotype, even after adjusting for the effect of IQ (P-value=0.021).

SNPs reported by this study (count: 2)

SNP	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
rs6332			allelic P-value=0.774, X² (1df)=0.082, genotypic P-value=0.938, X² (2df)=0.129 in boys; allelic P-value=0.254, X² (1df)=1.304, genotypic P-value=0.166 in girls; TDT P-value=0.801, X² (1df)=0.06 in all; TDT P-value=0.469, X² (1df)=0.53 in boys; TDT P-value=0.251, X² (1df)=1.32 in girls	no significant differences between the ADHD and control grou...... no significant differences between the ADHD and control groups in the genotype or allele frequencies and no preferential transmission from the TDT analysis More...	Non-significant
rs6489630			allelic P-value=0.855, X² (1df)=0.033, genotypic P-value=0.747, X² (2df)=0.583 in boys; allelic P-value=0.601, X² (1df)=0.274, genotypic P-value=0.506 in girls; TDT P-value=0.930, X² (1df)=0.01 in all; TDT P-value=0.926, X² (1df)=0.01 in boys; TDT P-value=0.593, X² (1df)=0.29 in girls	no significant differences between the ADHD and control grou...... no significant differences between the ADHD and control groups in the genotype or allele frequencies and no preferential transmission from the TDT analysis More...	Non-significant

Genes reported by this study (count: 1)