Gene Report
Basic Info
Approved Symbol |
NTF3
|
Symbol Alias |
NGF2 |
Approved Name |
neurotrophin 3 |
Location |
12p13 |
Position |
chr12:5541280-5604465, + |
External Links |
HGNC: 8023
Entrez Gene: 4908
Ensembl: ENSG00000185652
UCSC: uc001qnk.3
|
No. of Studies |
3 (significant: 1; non-significant: 2; trend: 0) |
Source |
Literature-origin; Mapped by LD-proxy; Mapped by literature SNP |
Gene related studies (count: 3)
Gene related SNPs (count: 22)
Gene related CNVs (count: 0)
Gene related other variant (count: 0)
Gene related regions (count: 0)
Gene related GO terms (count: 38)
Gene related KEGG pathways (count: 2)
ID |
Name |
No. of Genes in ADHDgene |
Brief Description |
hsa04722 |
Neurotrophin signaling pathway |
24 |
Neurotrophins are a family of trophic factors involved in di......
Neurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT-3), and neurotrophin 4 (NT-4). Neurotrophins exert their functions through engagement of Trk tyrosine kinase receptors or p75 neurotrophin receptor (p75NTR). Neurotrophin/Trk signaling is regulated by connecting a variety of intracellular signaling cascades, which include MAPK pathway, PI-3 kinase pathway, and PLC pathway, transmitting positive signals like enhanced survival and growth. On the other hand, p75NTR transmits both positive and nagative signals. These signals play an important role for neural development and additional higher-order activities such as learning and memory.
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|
hsa04010 |
MAPK signaling pathway |
69 |
The mitogen-activated protein kinase (MAPK) cascade is a hig......
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli.
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|
Genes shared at least 5 GO terms with NTF3 (count: 21)
Genes shared at least 2 KEGG pathways with NTF3 (count: 11)
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