ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Study Report

Basic Info

Reference	Li J, 2006(b)16563621
Citation	Li J., Wang Y., Zhou R., Wang B., Zhang H., Yang L. and Faraone S. V. (2006) "Association of attention-deficit/hyperactivity disorder with serotonin 4 receptor gene polymorphisms in Han Chinese subjects." Neurosci Lett, 401(1-2): 6-9.
Study Design	family-based
Study Type	Candidate-gene association study
Sample Size	326 nuclear families
Predominant Ethnicity	Mongoloid
Population	China
Gender	275 were male and 51 were female
Age Group	Children/Adolescents : mean age11.0,SD=2.3 years

Detail Info

Summary	To further investigate the role of other genes of the serotonergic pathway in ADHD, the current study examined variants of the serotonin 4 receptor gene in a relatively large sample of ADHD nuclear families. The T allele of the 83097 C> T polymorphism of HTR4 showed a tendency of preferential transmission to probands with ADHD. When haplotype TDT analysis of HTR4 was performed, they further found that the C/G haplotype of the 83097 C> T and 83198 A>G polymorphisms and the C/G/C haplotype of these and the -36 C> T polymorphism were under-transmitted to probands with ADHD. These results suggest that the HTR4 gene may play a role in the genetic predisposition to ADHD.
Total Sample	Three hundred and twenty six nuclear families participated in the present study. ADHD probands were recruited from the ADHD outpatient clinic at the Child and Adolescent Psychiatric Division of the Sixth Hospital, Peking University in Beijing, PRC. Among these probands, 275 were male and 51 were female. The average age was 11.0,SD=2.3 years and the average intelligence quotient (IQ) was 101.1,SD=13.5.
Sample Collection	Han Chinese
Diagnosis Description	All probands were interviewed by at least two different child psychiatrists with the aid of their biological parents and teachers, fulfilled DSM-IV diagnostic criteria for ADHD. One hundred and thirty-four (41.1%) probands met criteria for ADHD combined type (ADHD-C), 19 (5.8%) met criteria for ADHD hyperactive-impulsive type (ADHD-HI), and 173 (53.1%) met criteria forADHDinattentive type (ADHD-I).
Technique	Genomic DNA was extracted from blood using standard procedures. 83097C>T, 83198 A>G and -36T>C poly-morphisms were genotyped using the conditions described by OhtsUnited Kingdomi et al. Genotypes were read by two independent readers, and ambiguous or unidentifiable results were reamplified and rescored. Samples that continued to amplify poorly were eliminated from the study.
Analysis Method	The transmission disequilibrium test (TDT) and the extended transmission disequilibrium test (ETDT) were performed to test for evidence of distorted transmission of alleles and haplotypes, respectively. They used Holm's sequential Bonferroni method to correct for multiple testing.
Result Description	The T allele of the 83097C>T polymorphism of HTR4 showed a tendency of preferential transmission to probands with ADHD. When haplotype TDT analysis of HTR4 was performed, they further found that the C/G haplotype of the 83097C>T and 83198 A>G polymorphisms and the C/G/C haplotype of these and the -36 C>T polymorphism were under-transmitted to probands with ADHD. These results suggest that the HTR4 gene may play a role in the genetic predisposition to ADHD.

Other variant reported by this study (count: 3)

Variant Name	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
HTR4 83097C>T	C/T		TDT P-value=0.1, X²=2.699 TDT P-value=0.1, X²=2.699	showed a tendency to be preferentially transmitted to ADHD probands	Non-significant
HTR4 83198A>G	A/G		TDT P-value=0.823, X²=0.05 TDT P-value=0.823, X²=0.05	was not statistically significant	Non-significant
HTR4 -36C>T	C/T		TDT P-value=0.538, X²=0.38 TDT P-value=0.538, X²=0.38	was not statistically significant	Non-significant

Genes reported by this study (count: 1)