ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	B3GAT3
Symbol Alias	GlcAT-I
Approved Name	beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)
Location	11q12
Position	chr11:62382768-62389647, -
External Links	HGNC: 923 Entrez Gene: 26229 Ensembl: ENSG00000149541 UCSC: uc001ntw.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 16)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 16)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0030204	chondroitin sulfate metabolic process	Biological Process		7
GO:0030203	glycosaminoglycan metabolic process	Biological Process		20
GO:0050650	chondroitin sulfate proteoglycan biosynthetic process	Biological Process		1
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0050651	dermatan sulfate proteoglycan biosynthetic process	Biological Process		1
GO:0006486	protein glycosylation	Biological Process		15
GO:0015012	heparan sulfate proteoglycan biosynthetic process	Biological Process		3
GO:0005975	carbohydrate metabolic process	Biological Process		50
GO:0006024	glycosaminoglycan biosynthetic process	Biological Process	NAS[10842173]	7
GO:0016021	integral to membrane	Cellular Component	NAS[10842173]	845
GO:0030145	manganese ion binding	Molecular Function		10
GO:0015018	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	Molecular Function	NAS[10842173]	2
GO:0015020	glucuronosyltransferase activity	Molecular Function		21
GO:0005794	Golgi apparatus	Cellular Component		157
GO:0005801	cis-Golgi network	Cellular Component		14
GO:0000139	Golgi membrane	Cellular Component		95

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa00532	Glycosaminoglycan biosynthesis - chondroitin sulfate	5	Glycosaminoglycans (GAGs) are linear polysaccharide chains c...... Glycosaminoglycans (GAGs) are linear polysaccharide chains consisting of repeating disaccharide units and form proteglycans by covalently attaching to their core proteins. Chondroitin sulfate (CS) is a glycosaminoglycan with the disaccharide unit GalNAc(b1-4)GlcA(b1-3), modified with ester-linked sulfate at certain positions. Dermatan sulfate (DS) is a modified form of CS, in which a portion of D-glucuronate residues is epimerized to L-iduronates. CS and DS are linked to serine residues in core proteins via a linkage tetrasaccharide formed by the transfer of xylose and three more residues [MD:M00057]. The assembly process of CS is initiated by the transfer of N-acetylgalactosamine to the linkage tetrasaccharide. The polymerization step is catalyzed by bifunctional enzymes (chondroitin synthases) that have both b1-3 glucuronosyltransferase and b1-4 N-acetylgalactosaminyltransferase activities [MD:M00058]. Chondroitin polymerization also requires the action of the chondroitin polymerizing factor. Sulfation of chondroitin in vertebrates is a complex process, with multiple sulfotransferases involved in 4-O sulfation and 6-O sulfation of N-acetylgalactosamine residues. Additional enzymes exist for epimerization of glucuronic acid to iduronic acid in DS, sulfation at the C-2 position of the uronic acids, and other patterns of sulfation found in unusual species of chondroitin. More...
hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate	5	Heparan sulfate (HS) is a glycosaminoglycan with the basic d...... Heparan sulfate (HS) is a glycosaminoglycan with the basic disaccharide unit GlcNAc(a1-4)GlcA(b1-4), containing N- and O-sulfate esters at various positions. HS is covalently attached to serine residues in a proteoglycan core protein via the linkage tetrasaccharide. The addition of the first GlcNAc residue is catalyzed by EXTL3 glycosyltransferase, followed by the polymerization steps catalyzed by EXT1 and EXT2 transferases. As the chains polymerize, HS undergoes a series of modification reactions catalyzed by at least four families of sulfotransferases and one epimerase. More...
hsa01100	Metabolic pathways	237

Genes shared at least 5 GO terms with B3GAT3 (count: 13)

Gene Symbol	Pathway Count	Pathway List
B3GAT1	8	chondroitin sulfate metabolic process; glycosaminoglycan metabolic process; small molecule metabolic process; protein glycosylation; carbohydrate metabolic process; integral to membrane; galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity; Golgi membrane;
DSE	8	chondroitin sulfate metabolic process; glycosaminoglycan metabolic process; small molecule metabolic process; heparan sulfate proteoglycan biosynthetic process; carbohydrate metabolic process; integral to membrane; Golgi apparatus; Golgi membrane;
CHPF	6	chondroitin sulfate metabolic process; glycosaminoglycan metabolic process; small molecule metabolic process; carbohydrate metabolic process; integral to membrane; Golgi membrane;
CHST9	6	chondroitin sulfate metabolic process; glycosaminoglycan metabolic process; small molecule metabolic process; carbohydrate metabolic process; integral to membrane; Golgi membrane;
CHST5	6	glycosaminoglycan metabolic process; small molecule metabolic process; carbohydrate metabolic process; integral to membrane; Golgi apparatus; Golgi membrane;
CHST6	6	glycosaminoglycan metabolic process; small molecule metabolic process; carbohydrate metabolic process; integral to membrane; Golgi apparatus; Golgi membrane;
HS3ST2	6	glycosaminoglycan metabolic process; small molecule metabolic process; carbohydrate metabolic process; glycosaminoglycan biosynthetic process; integral to membrane; Golgi membrane;
HS3ST5	6	glycosaminoglycan metabolic process; small molecule metabolic process; carbohydrate metabolic process; glycosaminoglycan biosynthetic process; integral to membrane; Golgi membrane;
GPC5	5	chondroitin sulfate metabolic process; glycosaminoglycan metabolic process; small molecule metabolic process; carbohydrate metabolic process; glycosaminoglycan biosynthetic process;
GPC6	5	chondroitin sulfate metabolic process; glycosaminoglycan metabolic process; small molecule metabolic process; carbohydrate metabolic process; glycosaminoglycan biosynthetic process;
B3GNT1	5	glycosaminoglycan metabolic process; small molecule metabolic process; protein glycosylation; carbohydrate metabolic process; Golgi membrane;
B4GALT4	5	glycosaminoglycan metabolic process; small molecule metabolic process; carbohydrate metabolic process; integral to membrane; Golgi membrane;
B4GALT6	5	glycosaminoglycan metabolic process; small molecule metabolic process; carbohydrate metabolic process; integral to membrane; Golgi membrane;

Genes shared at least 2 KEGG pathways with B3GAT3 (count: 3)

Gene Symbol	Pathway Count	Pathway List
B3GAT1	3	Glycosaminoglycan biosynthesis - chondroitin sulfate; Glycosaminoglycan biosynthesis - heparan sulfate; Metabolic pathways;
XYLT1	3	Glycosaminoglycan biosynthesis - chondroitin sulfate; Glycosaminoglycan biosynthesis - heparan sulfate; Metabolic pathways;
CHPF	2	Glycosaminoglycan biosynthesis - chondroitin sulfate; Metabolic pathways;

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Region: chr11:62382768..62389647 View in gBrowse