ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	HS3ST5
Symbol Alias	3-OST-5
Approved Name	heparan sulfate (glucosamine) 3-O-sulfotransferase 5
Location	6q22.31
Position	chr6:114376750-114664209, -
External Links	HGNC: 19419 Entrez Gene: 222537 Ensembl: ENSG00000249853 UCSC: uc003pwg.3
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by LD-proxy; Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 15)

Literature-origin SNPs (count: 0)

LD-proxies (count: 15)

rs_ID	Location	Functional Annotation
rs10484274	Chr6:114612973(Fwd)	intron_variant; nc_transcript_variant
rs10484273	Chr6:114618234(Fwd)	intron_variant; nc_transcript_variant
rs7770227	Chr6:114622214(Fwd)	intron_variant; nc_transcript_variant
rs7742475	Chr6:114624006(Fwd)	intron_variant; nc_transcript_variant
rs7739768	Chr6:114626642(Fwd)	intron_variant; nc_transcript_variant
rs6927808	Chr6:114631425(Fwd)	intron_variant; nc_transcript_variant
rs9488369	Chr6:114632392(Fwd)	intron_variant; nc_transcript_variant
rs785132	Chr6:114634471(Fwd)	intron_variant; nc_transcript_variant
rs10447428	Chr6:114634998(Fwd)	intron_variant; nc_transcript_variant
rs10447429	Chr6:114635085(Fwd)	intron_variant; nc_transcript_variant
rs12216474	Chr6:114649839(Fwd)	intron_variant; nc_transcript_variant
rs785145	Chr6:114650655(Fwd)	intron_variant; nc_transcript_variant
rs7349953	Chr6:114651277(Fwd)	intron_variant; nc_transcript_variant
rs1323056	Chr6:114653522(Fwd)	intron_variant; nc_transcript_variant
rs785137	Chr6:114655699(Fwd)	intron_variant; nc_transcript_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
6q22-23	chr6:114600000-139000000	1 (1/0/0)

Gene related GO terms (count: 13)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 13)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0016021	integral to membrane	Cellular Component	NAS[12138164]	845
GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification	Biological Process	IDA[12138164]	1
GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity	Molecular Function	IDA[12138164]	1
GO:0006477	protein sulfation	Biological Process	IDA[12138164]	2
GO:0006024	glycosaminoglycan biosynthetic process	Biological Process		7
GO:0005975	carbohydrate metabolic process	Biological Process		50
GO:0005515	protein binding	Molecular Function	IPI[12138164]	910
GO:0000139	Golgi membrane	Cellular Component		95
GO:0050819	negative regulation of coagulation	Biological Process	IDA[12138164]	1
GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding	Molecular Function	NAS[12138164]	3
GO:0046596	regulation of viral entry into host cell	Biological Process	IDA[12138164]	1
GO:0044281	small molecule metabolic process	Biological Process		248
GO:0030203	glycosaminoglycan metabolic process	Biological Process		20

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa00534	Glycosaminoglycan biosynthesis - heparan sulfate	5	Heparan sulfate (HS) is a glycosaminoglycan with the basic d...... Heparan sulfate (HS) is a glycosaminoglycan with the basic disaccharide unit GlcNAc(a1-4)GlcA(b1-4), containing N- and O-sulfate esters at various positions. HS is covalently attached to serine residues in a proteoglycan core protein via the linkage tetrasaccharide. The addition of the first GlcNAc residue is catalyzed by EXTL3 glycosyltransferase, followed by the polymerization steps catalyzed by EXT1 and EXT2 transferases. As the chains polymerize, HS undergoes a series of modification reactions catalyzed by at least four families of sulfotransferases and one epimerase. More...

Genes shared at least 5 GO terms with HS3ST5 (count: 10)

Gene Symbol	Pathway Count	Pathway List
B3GAT3	6	integral to membrane; glycosaminoglycan biosynthetic process; carbohydrate metabolic process; Golgi membrane; small molecule metabolic process; glycosaminoglycan metabolic process;
CHST5	6	integral to membrane; protein sulfation; carbohydrate metabolic process; Golgi membrane; small molecule metabolic process; glycosaminoglycan metabolic process;
HS3ST2	6	integral to membrane; glycosaminoglycan biosynthetic process; carbohydrate metabolic process; Golgi membrane; small molecule metabolic process; glycosaminoglycan metabolic process;
B3GAT1	5	integral to membrane; carbohydrate metabolic process; Golgi membrane; small molecule metabolic process; glycosaminoglycan metabolic process;
B4GALT4	5	integral to membrane; carbohydrate metabolic process; Golgi membrane; small molecule metabolic process; glycosaminoglycan metabolic process;
B4GALT6	5	integral to membrane; carbohydrate metabolic process; Golgi membrane; small molecule metabolic process; glycosaminoglycan metabolic process;
CHPF	5	integral to membrane; carbohydrate metabolic process; Golgi membrane; small molecule metabolic process; glycosaminoglycan metabolic process;
CHST6	5	integral to membrane; carbohydrate metabolic process; Golgi membrane; small molecule metabolic process; glycosaminoglycan metabolic process;
CHST9	5	integral to membrane; carbohydrate metabolic process; Golgi membrane; small molecule metabolic process; glycosaminoglycan metabolic process;
DSE	5	integral to membrane; carbohydrate metabolic process; Golgi membrane; small molecule metabolic process; glycosaminoglycan metabolic process;

Genes shared at least 2 KEGG pathways with HS3ST5 (count: 0)

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Region: chr6:114376750..114664209 View in gBrowse