Gene Report
Basic Info
Approved Symbol |
CANX
|
Symbol Alias |
CNX, IP90, P90 |
Approved Name |
calnexin |
Name Alias |
major histocompatibility complex class I antigen-binding protein p88 |
Location |
5q35 |
Position |
chr5:179105629-179158642, + |
External Links |
HGNC: 1473
Entrez Gene: 821
Ensembl: ENSG00000127022
UCSC: uc003mkl.2
|
No. of Studies |
0 (significant: 0; non-significant: 0; trend: 0) |
Source |
Mapped by CNV |
Gene related studies (count: 0)
Gene related SNPs (count: 0)
Gene related CNVs (count: 1)
Gene related other variant (count: 0)
Gene related regions (count: 0)
Gene related GO terms (count: 25)
Gene related KEGG pathways (count: 3)
ID |
Name |
No. of Genes in ADHDgene |
Brief Description |
hsa04145 |
Phagosome |
32 |
Phagocytosis is the process of taking in relatively large pa......
Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.
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|
hsa04612 |
Antigen processing and presentation |
9 |
|
hsa04141 |
Protein processing in endoplasmic reticulum |
26 |
The endoplasmic reticulum (ER) is a subcellular organelle wh......
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
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|
Genes shared at least 5 GO terms with CANX (count: 14)
Genes shared at least 2 KEGG pathways with CANX (count: 6)
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