ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CANX
Symbol Alias	CNX, IP90, P90
Approved Name	calnexin
Name Alias	major histocompatibility complex class I antigen-binding protein p88
Location	5q35
Position	chr5:179105629-179158642, +
External Links	HGNC: 1473 Entrez Gene: 821 Ensembl: ENSG00000127022 UCSC: uc003mkl.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Jarick[2012]_14	chr5:178157153-180497731 (NCBI36 / hg18)	2340579	5q35.3	dup

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 25)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 25)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0030424	axon	Cellular Component		35
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II	Biological Process		14
GO:0034185	apolipoprotein binding	Molecular Function		5
GO:0032839	dendrite cytoplasm	Cellular Component		2
GO:0042470	melanosome	Cellular Component		22
GO:0035255	ionotropic glutamate receptor binding	Molecular Function		6
GO:0043197	dendritic spine	Cellular Component		12
GO:0043025	neuronal cell body	Cellular Component		51
GO:0005788	endoplasmic reticulum lumen	Cellular Component		33
GO:0005783	endoplasmic reticulum	Cellular Component		100
GO:0005840	ribosome	Cellular Component		12
GO:0005789	endoplasmic reticulum membrane	Cellular Component	IDA[19723497]	140
GO:0007568	aging	Biological Process		29
GO:0006457	protein folding	Biological Process		28
GO:0018279	protein N-linked glycosylation via asparagine	Biological Process		24
GO:0009306	protein secretion	Biological Process	TAS[8055875]	2
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I	Biological Process		17
GO:0005509	calcium ion binding	Molecular Function		124
GO:0005515	protein binding	Molecular Function	IPI[17220478]	910
GO:0071556	integral to lumenal side of endoplasmic reticulum membrane	Cellular Component		3
GO:0072583	clathrin-mediated endocytosis	Biological Process		1
GO:0048488	synaptic vesicle endocytosis	Biological Process		3
GO:0051082	unfolded protein binding	Molecular Function		19
GO:0043687	post-translational protein modification	Biological Process		37
GO:0044267	cellular protein metabolic process	Biological Process		64

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04145	Phagosome	32	Phagocytosis is the process of taking in relatively large pa...... Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes. More...
hsa04612	Antigen processing and presentation	9
hsa04141	Protein processing in endoplasmic reticulum	26	The endoplasmic reticulum (ER) is a subcellular organelle wh...... The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis. More...

Genes shared at least 5 GO terms with CANX (count: 14)

Gene Symbol	Pathway Count	Pathway List
PDIA3	9	melanosome; endoplasmic reticulum lumen; endoplasmic reticulum; protein folding; protein N-linked glycosylation via asparagine; antigen processing and presentation of peptide antigen via MHC class I; protein binding; post-translational protein modification; cellular protein metabolic process;
HSPA5	7	melanosome; endoplasmic reticulum lumen; endoplasmic reticulum; endoplasmic reticulum membrane; calcium ion binding; protein binding; unfolded protein binding;
EDEM2	7	endoplasmic reticulum lumen; endoplasmic reticulum membrane; protein folding; protein N-linked glycosylation via asparagine; calcium ion binding; post-translational protein modification; cellular protein metabolic process;
EDEM3	7	endoplasmic reticulum lumen; endoplasmic reticulum membrane; protein folding; protein N-linked glycosylation via asparagine; calcium ion binding; post-translational protein modification; cellular protein metabolic process;
LMAN1	7	endoplasmic reticulum membrane; protein folding; protein N-linked glycosylation via asparagine; protein binding; unfolded protein binding; post-translational protein modification; cellular protein metabolic process;
SNCA	6	axon; ribosome; aging; calcium ion binding; protein binding; synaptic vesicle endocytosis;
GANAB	6	melanosome; endoplasmic reticulum lumen; protein folding; protein N-linked glycosylation via asparagine; post-translational protein modification; cellular protein metabolic process;
PDIA6	6	melanosome; endoplasmic reticulum lumen; endoplasmic reticulum; endoplasmic reticulum membrane; protein folding; protein binding;
TAPBP	6	endoplasmic reticulum; endoplasmic reticulum membrane; antigen processing and presentation of peptide antigen via MHC class I; protein binding; integral to lumenal side of endoplasmic reticulum membrane; unfolded protein binding;
F10	5	endoplasmic reticulum lumen; calcium ion binding; protein binding; post-translational protein modification; cellular protein metabolic process;
STS	5	endoplasmic reticulum lumen; endoplasmic reticulum; endoplasmic reticulum membrane; post-translational protein modification; cellular protein metabolic process;
MAN1A1	5	endoplasmic reticulum; protein N-linked glycosylation via asparagine; calcium ion binding; post-translational protein modification; cellular protein metabolic process;
ALG2	5	endoplasmic reticulum membrane; protein N-linked glycosylation via asparagine; protein binding; post-translational protein modification; cellular protein metabolic process;
STT3A	5	endoplasmic reticulum membrane; protein N-linked glycosylation via asparagine; protein binding; post-translational protein modification; cellular protein metabolic process;

Genes shared at least 2 KEGG pathways with CANX (count: 6)

Gene Symbol	Pathway Count	Pathway List
HLA-DRB1	2	Phagosome; Antigen processing and presentation;
SEC61B	2	Phagosome; Protein processing in endoplasmic reticulum;
HSPA5	2	Antigen processing and presentation; Protein processing in endoplasmic reticulum;
HSPA6	2	Antigen processing and presentation; Protein processing in endoplasmic reticulum;
HSPA8	2	Antigen processing and presentation; Protein processing in endoplasmic reticulum;
PDIA3	2	Antigen processing and presentation; Protein processing in endoplasmic reticulum;

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Region: chr5:179105629..179158642 View in gBrowse