ADHDgene Database

Gene Report

Basic Info

Approved Symbol	EDEM3
Previous Symbol	C1orf22
Approved Name	ER degradation enhancer, mannosidase alpha-like 3
Previous Name	chromosome 1 open reading frame 22
Location	1q25
Position	chr1:184659625-184724047, -
External Links	HGNC: 16787 Entrez Gene: 80267 Ensembl: ENSG00000116406 UCSC: uc010pok.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
1q25.3	chr1:180300000-185800000	1 (1/0/0)

Gene related GO terms (count: 12)

ID	Name	Type	No. of Genes in ADHDgene
GO:0005789	endoplasmic reticulum membrane	Cellular Component	140
GO:0005788	endoplasmic reticulum lumen	Cellular Component	33
GO:0006516	glycoprotein catabolic process	Biological Process	1
GO:0006457	protein folding	Biological Process	28
GO:0018279	protein N-linked glycosylation via asparagine	Biological Process	24
GO:0006986	response to unfolded protein	Biological Process	10
GO:0043687	post-translational protein modification	Biological Process	37
GO:0043161	proteasomal ubiquitin-dependent protein catabolic process	Biological Process	16
GO:0044267	cellular protein metabolic process	Biological Process	64
GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	Molecular Function	3
GO:0005509	calcium ion binding	Molecular Function	124
GO:0004569	glycoprotein endo-alpha-1,2-mannosidase activity	Molecular Function	1

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04141	Protein processing in endoplasmic reticulum	26	The endoplasmic reticulum (ER) is a subcellular organelle wh...... The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis. More...

Genes shared at least 5 GO terms with EDEM3 (count: 6)

Gene Symbol	Pathway Count	Pathway List
EDEM2	9	endoplasmic reticulum membrane; endoplasmic reticulum lumen; protein folding; protein N-linked glycosylation via asparagine; response to unfolded protein; post-translational protein modification; cellular protein metabolic process; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity; calcium ion binding;
CANX	7	endoplasmic reticulum membrane; endoplasmic reticulum lumen; protein folding; protein N-linked glycosylation via asparagine; post-translational protein modification; cellular protein metabolic process; calcium ion binding;
LMAN1	5	endoplasmic reticulum membrane; protein folding; protein N-linked glycosylation via asparagine; post-translational protein modification; cellular protein metabolic process;
GANAB	5	endoplasmic reticulum lumen; protein folding; protein N-linked glycosylation via asparagine; post-translational protein modification; cellular protein metabolic process;
PDIA3	5	endoplasmic reticulum lumen; protein folding; protein N-linked glycosylation via asparagine; post-translational protein modification; cellular protein metabolic process;
MAN1A1	5	protein N-linked glycosylation via asparagine; post-translational protein modification; cellular protein metabolic process; mannosyl-oligosaccharide 1,2-alpha-mannosidase activity; calcium ion binding;

Genes shared at least 2 KEGG pathways with EDEM3 (count: 0)

View in gBrowse

Region: chr1:184659625..184724047 View in gBrowse