Gene Report
Basic Info
Approved Symbol |
EDEM2
|
Previous Symbol |
C20orf49, C20orf31 |
Symbol Alias |
FLJ10783, bA4204.1 |
Approved Name |
ER degradation enhancer, mannosidase alpha-like 2 |
Previous Name |
chromosome 20 open reading frame 31 |
Location |
20q11.22 |
Position |
chr20:33703160-33735167, - |
External Links |
HGNC: 15877
Entrez Gene: 55741
Ensembl: ENSG00000088298
UCSC: uc002xbo.2
|
No. of Studies |
0 (significant: 0; non-significant: 0; trend: 0) |
Source |
Mapped by LD-proxy; Mapped by literature SNP |
Gene related studies (count: 0)
Gene related SNPs (count: 9)
Gene related CNVs (count: 0)
Gene related other variant (count: 0)
Gene related regions (count: 0)
Gene related GO terms (count: 10)
Gene related KEGG pathways (count: 1)
ID |
Name |
No. of Genes in ADHDgene |
Brief Description |
hsa04141 |
Protein processing in endoplasmic reticulum |
26 |
The endoplasmic reticulum (ER) is a subcellular organelle wh......
The endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylated. Correctly folded proteins are packaged into transport vesicles that shuttle them to the Golgi complex. Misfolded proteins are retained within the ER lumen in complex with molecular chaperones. Proteins that are terminally misfolded bind to BiP and are directed toward degradation through the proteasome in a process called ER-associated degradation (ERAD). Accumulation of misfolded proteins in the ER causes ER stress and activates a signaling pathway called the unfolded protein response (UPR). In certain severe situations, however, the protective mechanisms activated by the UPR are not sufficient to restore normal ER function and cells die by apoptosis.
More...
|
Genes shared at least 5 GO terms with EDEM2 (count: 8)
Genes shared at least 2 KEGG pathways with EDEM2 (count: 0)
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