ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	GRIN3A
Approved Name	glutamate receptor, ionotropic, N-methyl-D-aspartate 3A
Location	9q
Position	chr9:104331634-104500862, -
External Links	HGNC: 16767 Entrez Gene: 116443 Ensembl: ENSG00000198785 UCSC: uc004bbp.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
9q31.1-33.1	chr9:102600000-122500000	1 (1/0/0)

Gene related GO terms (count: 23)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 1)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005262	calcium channel activity	Molecular Function		40

GO terms by database search (count: 22)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0045202	synapse	Cellular Component	IDA[17658481]	31
GO:0045211	postsynaptic membrane	Cellular Component		41
GO:0043005	neuron projection	Cellular Component	IDA[17658481]	35
GO:0043025	neuronal cell body	Cellular Component	IDA[17658481]	51
GO:0051721	protein phosphatase 2A binding	Molecular Function		6
GO:0060134	prepulse inhibition	Biological Process		10
GO:0045471	response to ethanol	Biological Process	IDA[18445116]	17
GO:0048511	rhythmic process	Biological Process		2
GO:0016594	glycine binding	Molecular Function	IDA[17320117]	2
GO:0017146	N-methyl-D-aspartate selective glutamate receptor complex	Cellular Component	IDA[17997397]	4
GO:0016021	integral to membrane	Cellular Component	NAS[11880201]	845
GO:0016358	dendrite development	Biological Process		9
GO:0042165	neurotransmitter binding	Molecular Function		1
GO:0042802	identical protein binding	Molecular Function	IPI[17997397]	70
GO:0030054	cell junction	Cellular Component		77
GO:0030288	outer membrane-bounded periplasmic space	Cellular Component		4
GO:0006816	calcium ion transport	Biological Process		32
GO:0005515	protein binding	Molecular Function	IPI[17658481]	910
GO:0016020	membrane	Cellular Component	IDA[17997397]	139
GO:0014069	postsynaptic density	Cellular Component		23
GO:0004972	N-methyl-D-aspartate selective glutamate receptor activity	Molecular Function	IDA[17502428]	3
GO:0005234	extracellular-glutamate-gated ion channel activity	Molecular Function		8

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04080	Neuroactive ligand-receptor interaction	93
hsa04724	Glutamatergic synapse	43	Glutamate is the major excitatory neurotransmitter in the ma...... Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system(CNS). Glutamate is packaged into synaptic vesicles in the presynaptic terminal. Once released into the synaptic cleft, glutamate acts on postsynaptic ionotropic glutamate receptors (iGluRs) to mediate fast excitatory synaptic transmission. Glutamate can also act on metabotropic glutamate receptors (mGluRs) and exert a variety of modulatory effects through their coupling to G proteins and the subsequent recruitment of second messenger systems. Presynaptically localized Group II and Group III mGluRs are thought to represent the classical inhibitory autoreceptor mechanism that suppresses excess glutamate release. After its action on these receptors, glutamate can be removed from the synaptic cleft by EAATs located either on the presynaptic terminal, neighboring glial cells, or the postsynaptic neuron. In glia, glutamate is converted to glutamine, which is then transported back to the presynaptic terminal and converted back to glutamate. More...

Genes shared at least 5 GO terms with GRIN3A (count: 17)

Gene Symbol	Pathway Count	Pathway List
GRIN2B	12	postsynaptic membrane; neuron projection; response to ethanol; glycine binding; N-methyl-D-aspartate selective glutamate receptor complex; cell junction; outer membrane-bounded periplasmic space; protein binding; postsynaptic density; N-methyl-D-aspartate selective glutamate receptor activity; calcium channel activity; extracellular-glutamate-gated ion channel activity;
GRIN2A	10	postsynaptic membrane; response to ethanol; N-methyl-D-aspartate selective glutamate receptor complex; cell junction; outer membrane-bounded periplasmic space; protein binding; postsynaptic density; N-methyl-D-aspartate selective glutamate receptor activity; calcium channel activity; extracellular-glutamate-gated ion channel activity;
GRID2	6	synapse; postsynaptic membrane; prepulse inhibition; cell junction; outer membrane-bounded periplasmic space; extracellular-glutamate-gated ion channel activity;
ADORA2A	6	postsynaptic membrane; neuronal cell body; prepulse inhibition; protein binding; membrane; postsynaptic density;
CHRNA4	6	postsynaptic membrane; neuronal cell body; integral to membrane; cell junction; calcium ion transport; membrane;
ACHE	5	synapse; postsynaptic membrane; cell junction; protein binding; membrane;
NLGN1	5	synapse; postsynaptic membrane; N-methyl-D-aspartate selective glutamate receptor complex; cell junction; postsynaptic density;
SNAP25	5	synapse; neuron projection; cell junction; protein binding; membrane;
CHRNA3	5	postsynaptic membrane; neuronal cell body; integral to membrane; cell junction; postsynaptic density;
GOPC	5	postsynaptic membrane; cell junction; protein binding; membrane; postsynaptic density;
SHANK2	5	postsynaptic membrane; neuron projection; cell junction; protein binding; postsynaptic density;
BAIAP2	5	neuron projection; dendrite development; identical protein binding; cell junction; protein binding;
SYT1	5	neuron projection; integral to membrane; identical protein binding; cell junction; protein binding;
CACNA1C	5	neuronal cell body; integral to membrane; protein binding; postsynaptic density; calcium channel activity;
SLC6A3	5	neuronal cell body; prepulse inhibition; response to ethanol; integral to membrane; protein binding;
PLN	5	integral to membrane; identical protein binding; calcium ion transport; protein binding; membrane;
RYR2	5	identical protein binding; calcium ion transport; protein binding; membrane; calcium channel activity;

Genes shared at least 2 KEGG pathways with GRIN3A (count: 10)

Gene Symbol	Pathway Count	Pathway List
GRIA4	2	Neuroactive ligand-receptor interaction; Glutamatergic synapse;
GRIK1	2	Neuroactive ligand-receptor interaction; Glutamatergic synapse;
GRIK4	2	Neuroactive ligand-receptor interaction; Glutamatergic synapse;
GRIN2A	2	Neuroactive ligand-receptor interaction; Glutamatergic synapse;
GRIN2B	2	Neuroactive ligand-receptor interaction; Glutamatergic synapse;
GRM1	2	Neuroactive ligand-receptor interaction; Glutamatergic synapse;
GRM5	2	Neuroactive ligand-receptor interaction; Glutamatergic synapse;
GRM6	2	Neuroactive ligand-receptor interaction; Glutamatergic synapse;
GRM7	2	Neuroactive ligand-receptor interaction; Glutamatergic synapse;
GRM8	2	Neuroactive ligand-receptor interaction; Glutamatergic synapse;

View in gBrowse

Region: chr9:104331634..104500862 View in gBrowse