ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	NPPC
Symbol Alias	CNP
Approved Name	natriuretic peptide C
Previous Name	natriuretic peptide precursor C
Location	2q24-qter
Position	chr2:232786530-232791113, -
External Links	HGNC: 7941 Entrez Gene: 4880 Ensembl: ENSG00000163273 UCSC: uc002vsl.1
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Hinney, A., 2011	This GWAS in a small group of clinically ascertained young German patients with ADHD and population-based controls did not reveal genome-wide significant findings. Replication attempts in further German and international samples did also not lead to a P-value(s) below 5E-08.	Non-significant

Gene related SNPs (count: 1)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs2580817	Chr2:232798723(Fwd)		1(0/1/0)

LD-proxies (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 25)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 25)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0051428	peptide hormone receptor binding	Molecular Function		1
GO:0045909	positive regulation of vasodilation	Biological Process		5
GO:0048660	regulation of smooth muscle cell proliferation	Biological Process		1
GO:0050880	regulation of blood vessel size	Biological Process		2
GO:0051053	negative regulation of DNA metabolic process	Biological Process		1
GO:0007168	receptor guanylyl cyclase signaling pathway	Biological Process	IDA[1672777]	2
GO:0006182	cGMP biosynthetic process	Biological Process	IDA[1672777]	2
GO:0008285	negative regulation of cell proliferation	Biological Process		59
GO:0008217	regulation of blood pressure	Biological Process		8
GO:0005179	hormone activity	Molecular Function		7
GO:0005102	receptor binding	Molecular Function	IPI[1660465]	61
GO:0005615	extracellular space	Cellular Component		126
GO:0005576	extracellular region	Cellular Component		240
GO:0042803	protein homodimerization activity	Molecular Function		113
GO:0042493	response to drug	Biological Process		68
GO:0045669	positive regulation of osteoblast differentiation	Biological Process		6
GO:0045471	response to ethanol	Biological Process		17
GO:0019229	regulation of vasoconstriction	Biological Process		3
GO:0009791	post-embryonic development	Biological Process		16
GO:0040014	regulation of multicellular organism growth	Biological Process		6
GO:0030828	positive regulation of cGMP biosynthetic process	Biological Process		3
GO:0003418	growth plate cartilage chondrocyte differentiation	Biological Process		1
GO:0003419	growth plate cartilage chondrocyte proliferation	Biological Process		1
GO:0001503	ossification	Biological Process		9
GO:0001666	response to hypoxia	Biological Process		34

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with NPPC (count: 1)

Gene Symbol	Pathway Count	Pathway List
IL6	5	negative regulation of cell proliferation; extracellular space; extracellular region; response to drug; positive regulation of osteoblast differentiation;

Genes shared at least 2 KEGG pathways with NPPC (count: 0)

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Region: chr2:232786530..232791113 View in gBrowse