ADHDgene Database

SNP Report

Basic Info

Name	rs1386496 dbSNP Ensembl
Location	Chr12:72350790(Fwd)
Variant Alleles	G/A
Ancestral Allele	G
Functional Annotation	NMD_transcript_variant; intron_variant.
Consequence to Transcript	NMD_transcript_variant(ENST00000546576) intron_variant(ENST00000546576; ENST00000333850)
No. of Studies	2 (significant: 0; non-significant: 2; trend: 0)
Source	Literature-origin

SNP related studies (count: 2)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Johansson S, 2010			logistic regression P-value=0.08, OR=1.27, meta-analysis P-v...... logistic regression P-value=0.08, OR=1.27, meta-analysis P-value=0.24, OR=0.89 More...	no significant association no significant association	Non-significant
Sheehan K, 2007		T	TDT test: P-value=0.636, OR=0.81 for full trios; P-value=0.8...... TDT test: P-value=0.636, OR=0.81 for full trios; P-value=0.804, OR=0.77 for paternal transmission; P-value=0.839, OR=0.85 for maternal transmission. More...	There is no significant difference in the transmission of al...... There is no significant difference in the transmission of alleles to ADHD cases. More...	Non-significant

SNP related genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
TPH2	tryptophan hydroxylase 2	12q15	10(7/3/0)

SNPs in LD with rs1386496 (count: 27) View in gBrowse (chr12:72344618..72398117 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

rs_ID	Functional Annotation	#studies(significant/non-significant/trend)	r²[population]

rs7963226	intron_variant	1(1/0/0)	0.913[CEU]; 0.846[CHB]; 1.0[CHD]; 1.0[GIH]; 1.0[TSI]
rs1843809	NMD_transcript_variant; intron_variant	5(3/2/0)	1.0[CEU]; 1.0[CHB]; 0.846[CHD]; 0.883[GIH]; 0.865[MEX]; 1.0[TSI]
rs1007023	intron_variant	1(1/0/0)	0.913[CEU]; 1.0[CHB]; 1.0[CHD]; 1.0[GIH]; 1.0[MEX]; 0.96[TSI]
rs6582072	NMD_transcript_variant; intron_variant	1(0/1/0)	0.847[CEU]
rs6582081	intron_variant	1(1/0/0)	0.831[CEU]; 0.846[CHB]; 1.0[CHD]; 1.0[GIH]; 0.859[MEX]; 1.0[TSI]
rs1386494	NMD_transcript_variant; intron_variant	1(0/1/0)	1.0[CEU]; 1.0[CHB]
rs7954568	intron_variant	1(1/0/0)	0.906[CEU]; 1.0[CHB]
rs1386493	NMD_transcript_variant; intron_variant	4(2/2/0)	0.847[CEU]
rs1386497	intron_variant	2(1/1/0)	0.913[CEU]; 0.846[CHB]; 0.917[CHD]; 0.929[MEX]; 0.893[TSI]
rs4760814	intron_variant	1(0/1/0)	0.913[CEU]; 1.0[CHB]
rs1386488	NMD_transcript_variant; intron_variant	2(0/2/0)	0.847[CEU]
rs4760818	intron_variant	2(1/1/0)	0.913[CEU]; 0.823[CHB]; 0.935[GIH]; 1.0[MEX]

rs_ID	Functional Annotation	r²[population]
rs990234	intron_variant	0.831[CEU]
rs7300490	intron_variant	0.913[CEU]
rs4760749	NMD_transcript_variant; intron_variant	1.0[CEU]; 1.0[CHB]
rs2046582	intron_variant	0.912[CEU]; 1.0[CHB]
rs1386489	NMD_transcript_variant; intron_variant	0.83[ASW]; 1.0[CEU]; 1.0[CHB]; 0.846[CHD]; 0.883[GIH]; 1.0[MEX]; 1.0[TSI]
rs4760751	intron_variant	0.913[CEU]; 1.0[CHB]; 1.0[CHD]; 1.0[GIH]; 1.0[MEX]; 1.0[TSI]
rs7968346	NMD_transcript_variant; intron_variant	1.0[CEU]; 1.0[CHB]
rs2367899	intron_variant	0.913[CEU]; 1.0[CHB]
rs10784944	downstream_gene_variant; intron_variant	0.83[ASW]; 1.0[CEU]; 1.0[CHB]; 0.846[CHD]; 0.871[GIH]; 1.0[MEX]; 1.0[TSI]
rs1487281	intron_variant	0.83[ASW]; 0.913[CEU]; 1.0[CHB]; 1.0[CHD]; 1.0[GIH]; 0.865[MEX]; 1.0[TSI]
rs10748189	intron_variant	0.831[CEU]; 1.0[CHB]
rs1386490	NMD_transcript_variant; intron_variant	0.912[CEU]; 1.0[CHB]
rs1843812	intron_variant	0.913[CEU]; 1.0[CHB]; 1.0[CHD]; 1.0[GIH]; 1.0[MEX]; 0.96[TSI]
rs7299582	3_prime_UTR_variant; NMD_transcript_variant; intron_variant	1.0[CEU]; 1.0[CHB]; 0.846[CHD]; 0.883[GIH]; 1.0[MEX]; 1.0[TSI]
rs10784942	NMD_transcript_variant; intron_variant	1.0[CEU]; 1.0[CHB]