ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

SNP Report

Basic Info

Name	rs4363087 dbSNP Ensembl
Location	Chr7:73118196(Fwd)
Variant Alleles	T/C
Ancestral Allele	C
Functional Annotation	3_prime_UTR_variant; NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant; upstream_gene_variant.
Consequence to Transcript	3_prime_UTR_variant(ENST00000436944; ENST00000423166) NMD_transcript_variant(ENST00000436944) downstream_gene_variant(ENST00000462135) intron_variant(ENST00000395154; ENST00000491427; ENST00000480126; ENST00000470878; ENST00000395155; ENST00000494245; ENST00000496216; ENST00000222812; ENST00000395156; ENST00000461441) nc_transcript_variant(ENST00000491427; ENST00000480126; ENST00000497980; ENST00000470878; ENST00000494245; ENST00000496216; ENST00000461441) non_coding_exon_variant(ENST00000497980) upstream_gene_variant(ENST00000484736; ENST00000491645)
No. of Studies	1 (significant: 1; non-significant: 0; trend: 0)
Source	Literature-origin

SNP related studies (count: 1)

Reference	Allele Change	Risk Allele	Statistical Values	Author Comments	Result of Statistical Analysis
Sanchez-Mora, C., 2012			P-value=0.003, Genotype12+22 vs11: P-value=0.001, OR(95%CI)=...... P-value=0.003, Genotype12+22 vs11: P-value=0.001, OR(95%CI)=1.44(1.15¨C1.80); Genotypes22 vs11+12: P-value=0.021, OR(95%CI)=1.45(1.06¨C1.98); allelic P-value=5.6e-04, OR(95%CI)=1.31(1.12¨C1.56) More...	When adults with ADHD were considered, nominal differences w...... When adults with ADHD were considered, nominal differences were found for nine SNPs located in five genes. After applying a FDR of 15%, only the four SNPs in STX1A remained associated with adulthood ADHD. More...	Significant

SNP related genes (count: 2)

Literature-origin genes (count: 1)

Approved Symbol	Approved Name	Location	No. of Studies (significant/non-significant/trend)
STX1A	syntaxin 1A (brain)	7q11.2	3(2/1/0)

Genes from other sources (count: 1)

Approved Symbol	Approved Name	Location
WBSCR22	Williams Beuren syndrome chromosome region 22	7q11.23

SNPs in LD with rs4363087 (count: 23) View in gBrowse (chr7:73087046..73125263 )

The LD data used here is based on HapMap rel#27. LD SNP pairs were selected with a threshold r²>=0.8.

Literature-origin SNPs (count: 2)

rs_ID	Functional Annotation	#studies(significant/non-significant/trend)	r²[population]

rs941298	intron_variant; nc_transcript_variant; upstream_gene_variant	1(1/0/0)	0.831[CEU]
rs3793243	downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	1(1/0/0)	0.862[CHB]

LD-proxies (count: 21)

rs_ID	Functional Annotation	r²[population]
rs4717101	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	0.831[CEU]
rs2293487	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	0.831[CEU]
rs12154779	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	1.0[YRI]
rs941297	downstream_gene_variant	0.871[CEU]; 1.0[YRI]
rs12531606	downstream_gene_variant; upstream_gene_variant	0.871[CEU]
rs11769825	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	0.871[CEU]; 1.0[YRI]
rs2141167	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	0.88[CEU]
rs867500	3_prime_UTR_variant; NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant	0.805[CEU]
rs4644119	downstream_gene_variant	0.88[CEU]
rs10949826	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	0.831[CEU]
rs4717803	downstream_gene_variant; upstream_gene_variant	0.831[CEU]
rs1527454	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	0.831[CEU]
rs2293489	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant; upstream_gene_variant	0.831[CEU]
rs4717806	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	0.805[CEU]
rs941299	intron_variant; nc_transcript_variant; upstream_gene_variant	0.831[CEU]
rs2884050	downstream_gene_variant; upstream_gene_variant	0.818[CHB]; 0.895[JPT]
rs2293488	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	0.831[CEU]
rs2141166	NMD_transcript_variant; intron_variant; nc_transcript_variant; upstream_gene_variant	0.88[CEU]
rs10267271	downstream_gene_variant	1.0[CEU]; 0.907[CHB]; 0.895[JPT]
rs1001220	NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant	1.0[CEU]; 0.905[CHB]; 0.847[JPT]
rs7778762	3_prime_UTR_variant; NMD_transcript_variant; downstream_gene_variant; intron_variant; nc_transcript_variant; non_coding_exon_variant	0.831[CEU]