ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	ATG5
Previous Symbol	APG5L
Symbol Alias	ASP, APG5, hAPG5
Approved Name	ATG5 autophagy related 5 homolog (S. cerevisiae)
Previous Name	APG5 (autophagy 5, S. cerevisiae)-like, "APG5 autophagy 5-like (S. cerevisiae)"
Location	6q21
Position	chr6:106632351-106773695, -
External Links	HGNC: 589 Entrez Gene: 9474 Ensembl: ENSG00000057663 UCSC: uc003prf.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Elia[2010]_65	chr6:106626358-107036437 (NCBI Build 35 (hg17))	410080	6q21	Duplication	Paternal

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 18)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 18)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0001974	blood vessel remodeling	Biological Process		7
GO:0000045	autophagic vacuole assembly	Biological Process		3
GO:0005737	cytoplasm	Cellular Component		690
GO:0005515	protein binding	Molecular Function		910
GO:0006914	autophagy	Biological Process		13
GO:0005776	autophagic vacuole	Cellular Component	IDA[15292400]	4
GO:0031397	negative regulation of protein ubiquitination	Biological Process		5
GO:0006915	apoptotic process	Biological Process		111
GO:0034045	pre-autophagosomal structure membrane	Cellular Component		2
GO:0032480	negative regulation of type I interferon production	Biological Process		10
GO:0043066	negative regulation of apoptotic process	Biological Process		77
GO:0043687	post-translational protein modification	Biological Process		37
GO:0042311	vasodilation	Biological Process		3
GO:0042493	response to drug	Biological Process		68
GO:0055015	ventricular cardiac muscle cell development	Biological Process		2
GO:0060047	heart contraction	Biological Process		2
GO:0045087	innate immune response	Biological Process		54
GO:0048840	otolith development	Biological Process		1

Gene related KEGG pathways (count: 3)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa05131	Shigellosis	13	Shigellosis, or bacillary dysentery, is an intestinal infect...... Shigellosis, or bacillary dysentery, is an intestinal infection caused by Shigella, a genus of enterobacteria. Shigella are potential food-borne pathogens that are capable of colonizing the intestinal epithelium by exploiting epithelial-cell functions and circumventing the host innate immune response. During basolateral entry into the host-cell cytoplasm, Shigella deliver a subset of effectors into the host cells through the type III secretion system. The effectors induce membrane ruffling through the stimulation of the Rac1-WAVE-Arp2/3 pathway, enabling bacterial entry into the epithelial cells. During multiplication within the cells, Shigella secrete another subset of effectors. VirG induces actin polymerization at one pole of the bacteria, allowing the bacteria to spread intracellularly and to infect adjacent cells. OspF, OspG and IpaH(9.8) downregulate the production of proinflammatory cytokines such as IL-8, helping bacteria circumvent the innate immune response. More...
hsa04622	RIG-I-like receptor signaling pathway	10	Specific families of pattern recognition receptors are respo...... Specific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular viral replication is recognized by a family of cytosolic RNA helicases termed RIG-I-like receptors (RLRs). The RLR proteins include RIG-I, MDA5, and LGP2 and are expressed in both immune and nonimmune cells. Upon recognition of viral nucleic acids, RLRs recruit specific intracellular adaptor proteins to initiate signaling pathways that lead to the synthesis of type I interferon and other inflammatory cytokines, which are important for eliminating viruses. More...
hsa04140	Regulation of autophagy	6

Genes shared at least 5 GO terms with ATG5 (count: 3)

Gene Symbol	Pathway Count	Pathway List
TNFAIP3	6	cytoplasm; protein binding; negative regulation of protein ubiquitination; negative regulation of type I interferon production; negative regulation of apoptotic process; innate immune response;
RELA	5	cytoplasm; protein binding; negative regulation of apoptotic process; response to drug; innate immune response;
TAX1BP1	5	protein binding; apoptotic process; negative regulation of type I interferon production; negative regulation of apoptotic process; innate immune response;

Genes shared at least 2 KEGG pathways with ATG5 (count: 2)

Gene Symbol	Pathway Count	Pathway List
MAPK9	2	Shigellosis; RIG-I-like receptor signaling pathway;
RELA	2	Shigellosis; RIG-I-like receptor signaling pathway;

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Region: chr6:106632351..106773695 View in gBrowse