ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	RELA
Previous Symbol	NFKB3
Symbol Alias	p65
Approved Name	v-rel reticuloendotheliosis viral oncogene homolog A (avian)
Previous Name	nuclear factor of kappa light polypeptide gene enhancer in B-cells 3
Location	11q13
Position	chr11:65421067-65430565, -
External Links	HGNC: 9955 Entrez Gene: 5970 Ensembl: ENSG00000173039 UCSC: uc001ofg.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
11q	chr11:53700000-135006516	2 (1/1/0)

Gene related GO terms (count: 77)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 77)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0071532	ankyrin repeat binding	Molecular Function		1
GO:0071356	cellular response to tumor necrosis factor	Biological Process	IDA[18073330]	9
GO:0071347	cellular response to interleukin-1	Biological Process	IDA[18073330]	3
GO:0071222	cellular response to lipopolysaccharide	Biological Process		13
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process	IDA[18073330]	80
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Biological Process	IDA[17350185]	131
GO:0045087	innate immune response	Biological Process		54
GO:0045892	negative regulation of transcription, DNA-dependent	Biological Process	IDA[17350185]	64
GO:0048011	nerve growth factor receptor signaling pathway	Biological Process		42
GO:0050727	regulation of inflammatory response	Biological Process		8
GO:0046627	negative regulation of insulin receptor signaling pathway	Biological Process		5
GO:0047485	protein N-terminus binding	Molecular Function	IPI[7739562]	23
GO:0051092	positive regulation of NF-kappaB transcription factor activity	Biological Process	IDA[15790681]	27
GO:0051591	response to cAMP	Biological Process		11
GO:0050852	T cell receptor signaling pathway	Biological Process		21
GO:0051059	NF-kappaB binding	Molecular Function	IPI[8441377]	7
GO:0070491	repressing transcription factor binding	Molecular Function	IPI[10660609]	2
GO:0070555	response to interleukin-1	Biological Process	IGI[15489227]	6
GO:0051607	defense response to virus	Biological Process	NAS[8717528]	15
GO:0070431	nucleotide-binding oligomerization domain containing 2 signaling pathway	Biological Process	IDA[12527755]	1
GO:0006954	inflammatory response	Biological Process	IDA[12924514]	51
GO:0006117	acetaldehyde metabolic process	Biological Process		1
GO:0005829	cytosol	Cellular Component		447
GO:0005737	cytoplasm	Cellular Component	IDA[15790681]	690
GO:0005667	transcription factor complex	Cellular Component	IDA[12048232]	51
GO:0005654	nucleoplasm	Cellular Component		183
GO:0005634	nucleus	Cellular Component	IDA[15790681]	770
GO:0005515	protein binding	Molecular Function		910
GO:0010033	response to organic substance	Biological Process	IDA[10747850]	4
GO:0009887	organ morphogenesis	Biological Process		19
GO:0009612	response to mechanical stimulus	Biological Process		9
GO:0008284	positive regulation of cell proliferation	Biological Process		69
GO:0008134	transcription factor binding	Molecular Function	IPI[10849440]	38
GO:0008063	Toll signaling pathway	Biological Process		11
GO:0007568	aging	Biological Process		29
GO:0006968	cellular defense response	Biological Process	NAS[8717528]	12
GO:0001889	liver development	Biological Process		14
GO:0003700	sequence-specific DNA binding transcription factor activity	Molecular Function	IDA[12048232]	132
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity	Molecular Function	IDA[3091258]	15
GO:0003677	DNA binding	Molecular Function	IDA[15790681]	220
GO:0003682	chromatin binding	Molecular Function	IDA[19058135]	48
GO:0002755	MyD88-dependent toll-like receptor signaling pathway	Biological Process		10
GO:0002756	MyD88-independent toll-like receptor signaling pathway	Biological Process		9
GO:0001942	hair follicle development	Biological Process		4
GO:0002224	toll-like receptor signaling pathway	Biological Process		10
GO:0042301	phosphate ion binding	Molecular Function	IDA[10521409]	3
GO:0042177	negative regulation of protein catabolic process	Biological Process		5
GO:0042542	response to hydrogen peroxide	Biological Process		6
GO:0042493	response to drug	Biological Process		68
GO:0034138	toll-like receptor 3 signaling pathway	Biological Process		11
GO:0034134	toll-like receptor 2 signaling pathway	Biological Process		10
GO:0035666	TRIF-dependent toll-like receptor signaling pathway	Biological Process		10
GO:0034142	toll-like receptor 4 signaling pathway	Biological Process		11
GO:0043565	sequence-specific DNA binding	Molecular Function		72
GO:0043278	response to morphine	Biological Process		9
GO:0045084	positive regulation of interleukin-12 biosynthetic process	Biological Process		2
GO:0044212	transcription regulatory region DNA binding	Molecular Function	IDA[17350185]	23
GO:0043066	negative regulation of apoptotic process	Biological Process	IDA[10747850]	77
GO:0042802	identical protein binding	Molecular Function	IDA[9437432]; IPI[10498867]	70
GO:0043200	response to amino acid stimulus	Biological Process		7
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	Biological Process	IEP[12761501]	27
GO:0019901	protein kinase binding	Molecular Function	IPI[15465828]	51
GO:0031293	membrane protein intracellular domain proteolysis	Biological Process		2
GO:0031625	ubiquitin protein ligase binding	Molecular Function	IPI[12748188]	23
GO:0032332	positive regulation of chondrocyte differentiation	Biological Process		3
GO:0010224	response to UV-B	Biological Process	IDA[15616591]	2
GO:0014040	positive regulation of Schwann cell differentiation	Biological Process		1
GO:0019048	virus-host interaction	Biological Process		54
GO:0019221	cytokine-mediated signaling pathway	Biological Process	IDA[15876188]	28
GO:0032868	response to insulin stimulus	Biological Process		11
GO:0033590	response to cobalamin	Biological Process		1
GO:0033613	activating transcription factor binding	Molecular Function	IPI[15489227]	1
GO:0034130	toll-like receptor 1 signaling pathway	Biological Process		10
GO:0032403	protein complex binding	Molecular Function		27
GO:0032481	positive regulation of type I interferon production	Biological Process		2
GO:0032495	response to muramyl dipeptide	Biological Process		2
GO:0032570	response to progesterone stimulus	Biological Process		7

Gene related KEGG pathways (count: 27)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa05200	Pathways in cancer	52
hsa05152	Tuberculosis	30	Tuberculosis, or TB, is an infectious disease caused by Myco...... Tuberculosis, or TB, is an infectious disease caused by Mycobacterium tuberculosis. One third of the world's population is thought to be infected with TB. About 90% of those infected result in latent infections, and about 10% of latent infections develop active diseases when their immune system is impaired due to the age, other diseases such as AIDS or exposure to immunosuppressive drugs. TB is transmitted through the air and primarily attacks the lungs, then it can spread by the circulatory system to other parts of body. Once TB bacilli have entered the host by the respiratory route and infected macrophages in the lungs, they interfere with phagosomal maturation, antigen presentation, apoptosis and host immune system to establish persistent or latent infection. More...
hsa05131	Shigellosis	13	Shigellosis, or bacillary dysentery, is an intestinal infect...... Shigellosis, or bacillary dysentery, is an intestinal infection caused by Shigella, a genus of enterobacteria. Shigella are potential food-borne pathogens that are capable of colonizing the intestinal epithelium by exploiting epithelial-cell functions and circumventing the host innate immune response. During basolateral entry into the host-cell cytoplasm, Shigella deliver a subset of effectors into the host cells through the type III secretion system. The effectors induce membrane ruffling through the stimulation of the Rac1-WAVE-Arp2/3 pathway, enabling bacterial entry into the epithelial cells. During multiplication within the cells, Shigella secrete another subset of effectors. VirG induces actin polymerization at one pole of the bacteria, allowing the bacteria to spread intracellularly and to infect adjacent cells. OspF, OspG and IpaH(9.8) downregulate the production of proinflammatory cytokines such as IL-8, helping bacteria circumvent the innate immune response. More...
hsa04622	RIG-I-like receptor signaling pathway	10	Specific families of pattern recognition receptors are respo...... Specific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular viral replication is recognized by a family of cytosolic RNA helicases termed RIG-I-like receptors (RLRs). The RLR proteins include RIG-I, MDA5, and LGP2 and are expressed in both immune and nonimmune cells. Upon recognition of viral nucleic acids, RLRs recruit specific intracellular adaptor proteins to initiate signaling pathways that lead to the synthesis of type I interferon and other inflammatory cytokines, which are important for eliminating viruses. More...
hsa05146	Amoebiasis	19	Entamoeba histolytica, an extracellular protozoan parasite i...... Entamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis of amoebiasis begins with parasite attachment and disruption of the intestinal mucus layer, followed by apoptosis of host epithelial cells. Intestinal tissue destruction causes severe dysentery and ulcerations in amoebic colitis. Several amoebic proteins such as lectins, cysteine proteineases, and amoebapores are associated with the invasion process. The parasite can cause extraintestinal infection like amoebic liver abscess by evading immune response. More...
hsa04623	Cytosolic DNA-sensing pathway	9	Specific families of pattern recognition receptors are respo...... Specific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified sensor of cytosolic DNA which activates the IRF and NF-{kappa}B transcription factors, leading to production of type I interferon and other cytokines. The second type of cytoplasmic DNA sensor is AIM2. Upon sensing DNA, AIM2 triggers the assembly of the inflammasome, culminating in interleukin maturation. In addition to these receptors, there is a mechanism to sense foreign DNA, with the host RNA polymerase III converting the DNA into RNA for recognition by the RNA sensor RIG-I. These pathways provide various means to alert the cell. More...
hsa04210	Apoptosis	13	Apoptosis is a genetically controlled mechanisms of cell dea...... Apoptosis is a genetically controlled mechanisms of cell death involved in the regulation of tissue homeostasis. The 2 major pathways of apoptosis are the extrinsic (Fas and other TNFR superfamily members and ligands) and the intrinsic (mitochondria-associated) pathways, both of which are found in the cytoplasm. The extrinsic pathway is triggered by death receptor engagement, which initiates a signaling cascade mediated by caspase-8 activation. Caspase-8 both feeds directly into caspase-3 activation and stimulates the release of cytochrome c by the mitochondria. Caspase-3 activation leads to the degradation of cellular proteins necessary to maintain cell survival and integrity. The intrinsic pathway occurs when various apoptotic stimuli trigger the release of cytochrome c from the mitochondria (independently of caspase-8 activation). Cytochrome c interacts with Apaf-1 and caspase-9 to promote the activation of caspase-3. Recent studies point to the ER as a third subcellular compartment implicated in apoptotic execution. Alterations in Ca2+ homeostasis and accumulation of misfolded proteins in the ER cause ER stress. Prolonged ER stress can result in the activation of BAD and/or caspase-12, and execute apoptosis. More...
hsa04660	T cell receptor signaling pathway	19	Activation of T lymphocytes is a key event for an efficient ...... Activation of T lymphocytes is a key event for an efficient response of the immune system. It requires the involvement of the T-cell receptor (TCR) as well as costimulatory molecules such as CD28. Engagement of these receptors through the interaction with a foreign antigen associated with major histocompatibility complex molecules and CD28 counter-receptors B7.1/B7.2, respectively, results in a series of signaling cascades. These cascades comprise an array of protein-tyrosine kinases, phosphatases, GTP-binding proteins and adaptor proteins that regulate generic and specialised functions, leading to T-cell proliferation, cytokine production and differentiation into effector cells. More...
hsa04010	MAPK signaling pathway	69	The mitogen-activated protein kinase (MAPK) cascade is a hig...... The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli. More...
hsa05162	Measles	20	Measles virus (MV) is highly contagious virus that leads inf...... Measles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacterial infections. Several MV proteins have been suggested to disturb host immunity. After infection of host lymphoid cells via SLAM, MV inhibits cytokine response by direct interference with host signaling systems. Three proteins (P, V, and C) associate with Jak/STAT proteins in interferon-triggered pathway and other important proteins related to apoptosis. Interaction between MV and host brings about the shift towards a Th2 response by decreasing IL-12 production and induces lymphopenia by suppressing cell proliferation. More...
hsa05120	Epithelial cell signaling in Helicobacter pylori infection	16	Two major virulence factors of H. pylori are the vacuolating...... Two major virulence factors of H. pylori are the vacuolating cytotoxin (VacA) and the cag type-IV secretion system (T4SS) and its translocated effector protein, cytotoxin-associated antigen A (CagA). More...
hsa04380	Osteoclast differentiation	25	The osteoclasts, multinucleared cells originating from the h...... The osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways activated by RANK and immune receptors, whose ligands are expressed on the surface of osteoblasts. Signaling from RANK changes gene expression patterns through transcription factors like NFATc1 and characterizes the active osteoclast. More...
hsa04062	Chemokine signaling pathway	32	Inflammatory immune response requires the recruitment of leu...... Inflammatory immune response requires the recruitment of leukocytes to the site of inflammation upon foreign insult. Chemokines are small chemoattractant peptides that provide directional cues for the cell trafficking and thus are vital for protective host response. In addition, chemokines regulate plethora of biological processes of hematopoietic cells to lead cellular activation, differentiation and survival. More...
hsa05140	Leishmaniasis	14	Leishmania is an intracellular protozoan parasite of macroph...... Leishmania is an intracellular protozoan parasite of macrophages that causes visceral, mucosal, and cutaneous diseases. The parasite is transmitted to humans by sandflies, where they survive and proliferate intracellularly by deactivating the macrophage. Successful infection of Leishmania is achieved by alteration of signaling events in the host cell, leading to enhanced production of the autoinhibitory molecules like TGF-beta and decreased induction of cytokines such as IL12 for protective immunity. Nitric oxide production is also inhibited. In addition, defective expression of major histocompatibility complex (MHC) genes silences subsequent T cell activation mediated by macrophages, resulting in abnormal immune responses. More...
hsa05145	Toxoplasmosis	33	Toxoplasma gondii is an obligate intracellular parasite that...... Toxoplasma gondii is an obligate intracellular parasite that is prevalent worldwide. The tachyzoite form acquired by oral ingestion downmodulates proinflammatory signaling pathways via various mechanisms. During early infection, nuclear translocation of NFkB is temporally blocked and p38 MAPK phosphorylation is prevented, suppressing IL-12 production. Another pathway for IL-12 induction occurs through CCR5 dependent pathway, but parasitic induction of an eicosanoid LXA4 contributes to the downregulation of IL-12. Direct activation of STAT3 by the parasite enhance anti-inflammatory function of IL-10 and TGF beta. T. gondii can cause lifelong chronic infection by establishing an anti-apoptotic environment through induction of bcl-2 or IAPs and by redirecting LDL-mediated cholesterol transport to scavenge nutrients from the host. More...
hsa04722	Neurotrophin signaling pathway	24	Neurotrophins are a family of trophic factors involved in di...... Neurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic factor (BDNF), neurotrophin 3 (NT-3), and neurotrophin 4 (NT-4). Neurotrophins exert their functions through engagement of Trk tyrosine kinase receptors or p75 neurotrophin receptor (p75NTR). Neurotrophin/Trk signaling is regulated by connecting a variety of intracellular signaling cascades, which include MAPK pathway, PI-3 kinase pathway, and PLC pathway, transmitting positive signals like enhanced survival and growth. On the other hand, p75NTR transmits both positive and nagative signals. These signals play an important role for neural development and additional higher-order activities such as learning and memory. More...
hsa04920	Adipocytokine signaling pathway	8	Increased adipocyte volume and number are positively correla...... Increased adipocyte volume and number are positively correlated with leptin production, and negatively correlated with production of adiponectin. More...
hsa04662	B cell receptor signaling pathway	14	B cells are an important component of adaptive immunity. The...... B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor (BCR) is an integral membrane protein complex that is composed of two immunoglobulin (Ig) heavy chains, two Ig light chains and two heterodimers of Ig-alpha and Ig-beta. After BCR ligation by antigen, three main protein tyrosine kinases (PTKs) -the SRC-family kinase LYN, SYK and the TEC-family kinase BTK- are activated. Phosphatidylinositol 3-kinase (PI3K) and phospholipase C-gamma 2 (PLC-gamma 2) are important downstream effectors of BCR signalling. This signalling ultimately results in the expression of immediate early genes that further activate the expression of other genes involved in B cell proliferation, differentiation and Ig production as well as other processes. More...
hsa05221	Acute myeloid leukemia	10	Acute myeloid leukemia (AML) is a disease that is characteri...... Acute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation program. AML accounts for approximately 80% of all adult leukemias and remains the most common cause of leukemia death. Two major types of genetic events have been described that are crucial for leukemic transformation. A proposed necessary first event is disordered cell growth and upregulation of cell survival genes. The most common of these activating events were observed in the RTK Flt3, in N-Ras and K-Ras, in Kit, and sporadically in other RTKs. Alterations in myeloid transcription factors governing hematopoietic differentiation provide second necessary event for leukemogenesis. Transcription factor fusion proteins such as AML-ETO, PML-RARalpha or PLZF-RARalpha block myeloid cell differentiation by repressing target genes. In other cases, the transcription factors themselves are mutated. More...
hsa05220	Chronic myeloid leukemia	12	Chronic myelogenous leukemia (CML) originates in a pluripote...... Chronic myelogenous leukemia (CML) originates in a pluripotent hematopoetic stem cell of the bone marrow and is characterized by greatly increased numbers of granulocytes in the blood. Myeloid and other hematopoetic cell lineages are involved in the process of clonal proliferation and differentiation. On the cellular level, CML is associated with a specific chromosome abnormality, the t(9; 22) reciprocal translocation that forms the Philadelphia (Ph) chromosome. The Ph chromosome is the result of a molecular rearrangement between the c-ABL proto-oncogene on chromosome 9 and the BCR (breakpoint cluster region) gene on chromosome 22. The BCR/ABL fusion gene encodes p210 BCR/ABL, an oncoprotein, which, unlike the normal p145 c-Abl, has constitutive tyrosine kinase activity and is predominantly localized in the cytoplasm. While fusion of c-ABL and BCR is believed to be the primary cause of the chronic phase of CML, progression to blast crisis requires other molecular changes. Common secondary abnormalities include mutations in TP53, RB, and p16/INK4A, or overexpression of genes such as EVI1. Additional chromosome translocations are also observed,such as t(3;21)(q26;q22), which generates AML1-EVI1. More...
hsa05215	Prostate cancer	13	Prostate cancer constitutes a major health problem in Wester...... Prostate cancer constitutes a major health problem in Western countries. It is the most frequently diagnosed cancer among men and the second leading cause of male cancer deaths. The identification of key molecular alterations in prostate-cancer cells implicates carcinogen defenses (GSTP1), growth-factor-signaling pathways (NKX3.1, PTEN, and p27), and androgens (AR) as critical determinants of the phenotype of prostate-cancer cells. Glutathione S-transferases (GSTP1) are detoxifying enzymes. Cells of prostatic intraepithelial neoplasia, devoid of GSTP1, undergo genomic damage mediated by carcinogens. NKX3.1, PTEN, and p27 regulate the growth and survival of prostate cells in the normal prostate. Inadequate levels of PTEN and NKX3.1 lead to a reduction in p27 levels and to increased proliferation and decreased apoptosis. Androgen receptor (AR) is a transcription factor that is normally activated by its androgen ligand. During androgen withdrawal therapy, the AR signal transduction pathway also could be activated by amplification of the AR gene, by AR gene mutations, or by altered activity of AR coactivators. Through these mechanisms, tumor cells lead to the emergence of androgen-independent prostate cancer. More...
hsa05212	Pancreatic cancer	13	Infiltrating ductal adenocarcinoma is the most common malign...... Infiltrating ductal adenocarcinoma is the most common malignancy of the pancreas. When most investigators use the term 'pancreatic cancer' they are referring to pancreatic ductal adenocarcinoma (PDA). Normal duct epithelium progresses to infiltrating cancer through a series of histologically defined precursors (PanINs). The overexpression of HER-2/neu and activating point mutations in the K-ras gene occur early, inactivation of the p16 gene at an intermediate stage, and the inactivation of p53, SMAD4, and BRCA2 occur relatively late. Activated K-ras engages multiple effector pathways. Although EGF receptors are conventionally regarded as upstream activators of RAS proteins, they can also act as RAS signal transducers via RAS-induced autocrine activation of the EGFR family ligands. Moreover, PDA shows extensive genomic instability and aneuploidy. Telomere attrition and mutations in p53 and BRCA2 are likely to contribute to these phenotypes. Inactivation of the SMAD4 tumour suppressor gene leads to loss of the inhibitory influence of the transforming growth factor-beta signalling pathway. More...
hsa05160	Hepatitis C	17	Hepatitis C virus (HCV) is a major cause of chronic liver di...... Hepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the cytoplasm of the host cell and forms membrane-associated replication complexes along with non-structural proteins. Viral RNA can trigger the RIG-I pathway and interferon production during this process. Translated HCV protein products regulate immune response to inhibit the action of interferon. HCV core and NS5A proteins appear to be the most important molecules with regulatory functions that modulate transcription, cellular proliferation, and apoptosis. More...
hsa05222	Small cell lung cancer	16	Lung cancer is a leading cause of cancer death among men and...... Lung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% of all lung cancer cases. Molecular mechanisms altered in SCLC include induced expression of oncogene, MYC, and loss of tumorsuppressor genes, such as p53, PTEN, RB, and FHIT. The overexpression of MYC proteins in SCLC is largely a result of gene amplification. Such overexpression leads to more rapid proliferation and loss of terminal differentiation. Mutation or deletion of p53 or PTEN can lead to more rapid proliferation and reduced apoptosis. The retinoblastoma gene RB1 encodes a nuclear phosphoprotein that helps to regulate cell-cycle progression. The fragile histidine triad gene FHIT encodes the enzyme diadenosine triphosphate hydrolase, which is thought to have an indirect role in proapoptosis and cell-cycle control. More...
hsa04621	NOD-like receptor signaling pathway	16	Specific families of pattern recognition receptors are respo...... Specific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains more than 20 members in mammals and plays a pivotal role in the recognition of intracellular ligands. NOD1 and NOD2, two prototypic NLRs, sense the cytosolic presence of the bacterial peptidoglycan fragments that escaped from endosomal compartments, driving the activation of NF-{kappa}B and MAPK, cytokine production and apoptosis. On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. These NLRs include NALP1, NALP3 and Ipaf. The inflammasomes are critical for generating mature proinflammatory cytokines in concert with Toll-like receptor signaling pathway. More...
hsa05142	Chagas disease (American trypanosomiasis)	23	Trypanosoma cruzi is an intracellular protozoan parasite tha...... Trypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they invade diverse host cells including cardiomyocytes. Establishment of infection depends on various parasite molecules such as cruzipain, oligopeptidase B, and trans-sialidase that activate Ca2+ signaling. Internalized parasites escape from the parasitophorous vacuole using secreted pore-forming TcTOX molecule and replicate in the cytosol. Multiplied parasites eventually lyse infected host cells and are released in the circulation. During these events, the parasites manipulate host innate immunity and elicit cardiomyocyte hypertrophy. T lymphocyte responses are also disturbed. More...
hsa04620	Toll-like receptor signaling pathway	13	Specific families of pattern recognition receptors are respo...... Specific families of pattern recognition receptors are responsible for detecting microbial pathogens and generating innate immune responses. Toll-like receptors (TLRs) are membrane-bound receptors identified as homologs of Toll in Drosophila. Mammalian TLRs are expressed on innate immune cells, such as macrophages and dendritic cells, and respond to the membrane components of Gram-positive or Gram-negative bacteria. Pathogen recognition by TLRs provokes rapid activation of innate immunity by inducing production of proinflammatory cytokines and upregulation of costimulatory molecules. TLR signaling pathways are separated into two groups: a MyD88-dependent pathway that leads to the production of proinflammatory cytokines with quick activation of NF-{kappa}B and MAPK, and a MyD88-independent pathway associated with the induction of IFN-beta and IFN-inducible genes, and maturation of dendritic cells with slow activation of NF-{kappa}B and MAPK. More...

Genes shared at least 5 GO terms with RELA (count: 236)

Gene Symbol	Pathway Count	Pathway List
MAPK1	23	positive regulation of transcription, DNA-dependent; innate immune response; nerve growth factor receptor signaling pathway; T cell receptor signaling pathway; cytosol; cytoplasm; nucleoplasm; nucleus; protein binding; organ morphogenesis; positive regulation of cell proliferation; transcription factor binding; Toll signaling pathway; DNA binding; MyD88-dependent toll-like receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; toll-like receptor signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 2 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; toll-like receptor 4 signaling pathway; virus-host interaction; toll-like receptor 1 signaling pathway;
MAPK9	20	cellular response to tumor necrosis factor; cellular response to interleukin-1; cellular response to lipopolysaccharide; positive regulation of transcription, DNA-dependent; innate immune response; cytosol; nucleoplasm; protein binding; response to mechanical stimulus; transcription factor binding; Toll signaling pathway; MyD88-dependent toll-like receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; toll-like receptor signaling pathway; response to drug; toll-like receptor 3 signaling pathway; toll-like receptor 2 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 1 signaling pathway;
MAPK3	19	positive regulation of transcription from RNA polymerase II promoter; innate immune response; nerve growth factor receptor signaling pathway; cytosol; nucleoplasm; nucleus; protein binding; organ morphogenesis; Toll signaling pathway; MyD88-dependent toll-like receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; toll-like receptor signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 2 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; toll-like receptor 4 signaling pathway; virus-host interaction; cytokine-mediated signaling pathway; toll-like receptor 1 signaling pathway;
UBB	19	positive regulation of transcription from RNA polymerase II promoter; innate immune response; nerve growth factor receptor signaling pathway; positive regulation of NF-kappaB transcription factor activity; T cell receptor signaling pathway; cytosol; nucleoplasm; protein binding; Toll signaling pathway; MyD88-dependent toll-like receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; toll-like receptor signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 2 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; toll-like receptor 4 signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; cytokine-mediated signaling pathway; toll-like receptor 1 signaling pathway;
UBC	19	positive regulation of transcription from RNA polymerase II promoter; innate immune response; nerve growth factor receptor signaling pathway; positive regulation of NF-kappaB transcription factor activity; T cell receptor signaling pathway; cytosol; nucleoplasm; protein binding; Toll signaling pathway; MyD88-dependent toll-like receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; toll-like receptor signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 2 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; toll-like receptor 4 signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; cytokine-mediated signaling pathway; toll-like receptor 1 signaling pathway;
MAPK7	17	positive regulation of transcription from RNA polymerase II promoter; innate immune response; nerve growth factor receptor signaling pathway; cytosol; nucleoplasm; nucleus; protein binding; Toll signaling pathway; MyD88-dependent toll-like receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; toll-like receptor signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 2 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; toll-like receptor 4 signaling pathway; negative regulation of apoptotic process; toll-like receptor 1 signaling pathway;
TLR4	16	cellular response to lipopolysaccharide; positive regulation of transcription from RNA polymerase II promoter; innate immune response; positive regulation of NF-kappaB transcription factor activity; cytoplasm; protein binding; Toll signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 2 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; toll-like receptor 4 signaling pathway; positive regulation of interleukin-12 biosynthetic process; positive regulation of I-kappaB kinase/NF-kappaB cascade; toll-like receptor 1 signaling pathway;
MAP2K3	16	positive regulation of transcription, DNA-dependent; innate immune response; inflammatory response; cytosol; nucleoplasm; protein binding; Toll signaling pathway; MyD88-dependent toll-like receptor signaling pathway; MyD88-independent toll-like receptor signaling pathway; toll-like receptor signaling pathway; toll-like receptor 3 signaling pathway; toll-like receptor 2 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; toll-like receptor 4 signaling pathway; protein kinase binding; toll-like receptor 1 signaling pathway;
IRF7	15	positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; innate immune response; cytosol; cytoplasm; nucleoplasm; nucleus; protein binding; Toll signaling pathway; DNA binding; MyD88-independent toll-like receptor signaling pathway; toll-like receptor 3 signaling pathway; TRIF-dependent toll-like receptor signaling pathway; toll-like receptor 4 signaling pathway; cytokine-mediated signaling pathway;
GATA6	15	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; transcription factor complex; nucleoplasm; nucleus; protein binding; transcription factor binding; liver development; sequence-specific DNA binding transcription factor activity; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; chromatin binding; response to drug; transcription regulatory region DNA binding; negative regulation of apoptotic process; protein kinase binding;
IL6	13	positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; positive regulation of NF-kappaB transcription factor activity; defense response to virus; inflammatory response; response to mechanical stimulus; positive regulation of cell proliferation; aging; response to drug; negative regulation of apoptotic process; response to amino acid stimulus; cytokine-mediated signaling pathway; response to insulin stimulus;
GSK3B	13	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nerve growth factor receptor signaling pathway; NF-kappaB binding; cytosol; cytoplasm; nucleus; protein binding; organ morphogenesis; response to drug; negative regulation of apoptotic process; protein kinase binding; ubiquitin protein ligase binding;
SREBF1	13	positive regulation of transcription from RNA polymerase II promoter; response to cAMP; nucleus; protein binding; aging; sequence-specific DNA binding transcription factor activity; DNA binding; chromatin binding; response to drug; sequence-specific DNA binding; protein kinase binding; protein complex binding; response to progesterone stimulus;
ETS1	12	positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; response to interleukin-1; transcription factor complex; nucleus; protein binding; response to mechanical stimulus; positive regulation of cell proliferation; transcription factor binding; sequence-specific DNA binding transcription factor activity; DNA binding; sequence-specific DNA binding;
PYCARD	11	cellular response to tumor necrosis factor; cellular response to interleukin-1; cellular response to lipopolysaccharide; innate immune response; positive regulation of NF-kappaB transcription factor activity; defense response to virus; inflammatory response; cytosol; cytoplasm; nucleus; protein binding;
HMGA1	11	positive regulation of transcription, DNA-dependent; negative regulation of transcription, DNA-dependent; cytosol; transcription factor complex; nucleoplasm; nucleus; protein binding; transcription factor binding; sequence-specific DNA binding transcription factor activity; DNA binding; virus-host interaction;
HNF1B	11	positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; transcription factor complex; nucleus; protein binding; sequence-specific DNA binding transcription factor activity; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; DNA binding; sequence-specific DNA binding; transcription regulatory region DNA binding; negative regulation of apoptotic process;
HES1	11	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; cytoplasm; nucleus; protein binding; positive regulation of cell proliferation; transcription factor binding; liver development; sequence-specific DNA binding transcription factor activity; DNA binding; sequence-specific DNA binding;
KDM1A	11	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; transcription factor complex; nucleoplasm; nucleus; protein binding; transcription factor binding; sequence-specific DNA binding transcription factor activity; chromatin binding; transcription regulatory region DNA binding; negative regulation of apoptotic process;
MEN1	11	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; protein N-terminus binding; cytosol; cytoplasm; nucleoplasm; nucleus; protein binding; chromatin binding; sequence-specific DNA binding; transcription regulatory region DNA binding;
YAP1	11	positive regulation of transcription from RNA polymerase II promoter; cytosol; cytoplasm; transcription factor complex; nucleoplasm; nucleus; protein binding; positive regulation of cell proliferation; chromatin binding; transcription regulatory region DNA binding; negative regulation of apoptotic process;
TIRAP	11	innate immune response; positive regulation of NF-kappaB transcription factor activity; inflammatory response; protein binding; Toll signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 4 signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; toll-like receptor 1 signaling pathway;
FOSL1	11	response to cAMP; cytosol; nucleus; protein binding; response to mechanical stimulus; positive regulation of cell proliferation; cellular defense response; sequence-specific DNA binding transcription factor activity; response to hydrogen peroxide; response to drug; response to progesterone stimulus;
TNFAIP3	10	cellular response to lipopolysaccharide; innate immune response; inflammatory response; cytosol; cytoplasm; nucleus; protein binding; DNA binding; negative regulation of apoptotic process; response to muramyl dipeptide;
FOXC2	10	positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; transcription factor complex; nucleus; transcription factor binding; sequence-specific DNA binding transcription factor activity; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; transcription regulatory region DNA binding; negative regulation of apoptotic process;
FOXE1	10	positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; transcription factor complex; nucleus; transcription factor binding; sequence-specific DNA binding transcription factor activity; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; DNA binding; sequence-specific DNA binding;
KAT5	10	positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; repressing transcription factor binding; cytosol; transcription factor complex; nucleus; protein binding; virus-host interaction; protein complex binding;
TFAP2A	10	positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; cytoplasm; nucleus; protein binding; chromatin binding; sequence-specific DNA binding; transcription regulatory region DNA binding; negative regulation of apoptotic process;
FOXG1	10	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; transcription factor complex; nucleus; protein binding; transcription factor binding; aging; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; DNA binding; sequence-specific DNA binding;
PRKD1	10	positive regulation of transcription from RNA polymerase II promoter; innate immune response; positive regulation of NF-kappaB transcription factor activity; inflammatory response; cytosol; cytoplasm; nucleus; protein binding; identical protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade;
SNCA	10	protein N-terminus binding; response to interleukin-1; cytosol; cytoplasm; nucleus; protein binding; aging; response to drug; negative regulation of apoptotic process; identical protein binding;
FOXF1	9	positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; transcription factor complex; nucleus; transcription factor binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; DNA binding; sequence-specific DNA binding; transcription regulatory region DNA binding;
HINFP	9	positive regulation of transcription, DNA-dependent; negative regulation of transcription, DNA-dependent; nucleoplasm; nucleus; protein binding; sequence-specific DNA binding transcription factor activity; DNA binding; chromatin binding; transcription regulatory region DNA binding;
MED1	9	positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; nucleoplasm; nucleus; protein binding; transcription factor binding; liver development; chromatin binding; negative regulation of apoptotic process;
E2F5	9	positive regulation of transcription from RNA polymerase II promoter; cytoplasm; transcription factor complex; nucleoplasm; protein binding; organ morphogenesis; transcription factor binding; sequence-specific DNA binding transcription factor activity; DNA binding;
FOXP1	9	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; cytoplasm; transcription factor complex; nucleus; transcription factor binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; chromatin binding; sequence-specific DNA binding;
MALT1	9	innate immune response; positive regulation of NF-kappaB transcription factor activity; T cell receptor signaling pathway; cytosol; cytoplasm; nucleus; protein binding; negative regulation of apoptotic process; positive regulation of I-kappaB kinase/NF-kappaB cascade;
TRIM5	9	innate immune response; positive regulation of NF-kappaB transcription factor activity; defense response to virus; cytoplasm; nucleus; protein binding; identical protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade; virus-host interaction;
DAXX	9	negative regulation of transcription, DNA-dependent; protein N-terminus binding; cytosol; cytoplasm; nucleus; protein binding; transcription factor binding; ubiquitin protein ligase binding; virus-host interaction;
FOXP2	9	negative regulation of transcription, DNA-dependent; cytoplasm; transcription factor complex; transcription factor binding; sequence-specific DNA binding transcription factor activity; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; DNA binding; chromatin binding; sequence-specific DNA binding;
XRCC5	9	negative regulation of transcription, DNA-dependent; cytoplasm; nucleoplasm; nucleus; protein binding; DNA binding; transcription regulatory region DNA binding; negative regulation of apoptotic process; ubiquitin protein ligase binding;
BAD	9	nerve growth factor receptor signaling pathway; cytosol; protein binding; response to hydrogen peroxide; response to drug; response to amino acid stimulus; protein kinase binding; cytokine-mediated signaling pathway; response to progesterone stimulus;
NCOR1	9	cytoplasm; transcription factor complex; nucleoplasm; nucleus; protein binding; sequence-specific DNA binding transcription factor activity; chromatin binding; sequence-specific DNA binding; transcription regulatory region DNA binding;
ARRB1	8	positive regulation of transcription from RNA polymerase II promoter; cytosol; cytoplasm; nucleus; protein binding; transcription factor binding; transcription regulatory region DNA binding; ubiquitin protein ligase binding;
ATXN1	8	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; cytoplasm; nucleoplasm; nucleus; protein binding; DNA binding; identical protein binding;
FADD	8	positive regulation of transcription from RNA polymerase II promoter; innate immune response; defense response to virus; cytosol; protein binding; identical protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade; virus-host interaction;
HEY2	8	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; cytoplasm; nucleus; protein binding; transcription factor binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
MTA2	8	positive regulation of transcription from RNA polymerase II promoter; transcription factor complex; nucleus; protein binding; sequence-specific DNA binding transcription factor activity; chromatin binding; sequence-specific DNA binding; transcription regulatory region DNA binding;
NR5A1	8	positive regulation of transcription from RNA polymerase II promoter; nucleoplasm; nucleus; protein binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; DNA binding; chromatin binding; sequence-specific DNA binding;
RBPJ	8	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; cytoplasm; nucleoplasm; nucleus; protein binding; sequence-specific DNA binding transcription factor activity; DNA binding;
STRN3	8	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; cytoplasm; nucleoplasm; nucleus; protein binding; sequence-specific DNA binding transcription factor activity; protein complex binding;
NCF2	8	innate immune response; cytosol; cytoplasm; protein binding; aging; cellular defense response; response to drug; response to progesterone stimulus;
PRKCB	8	negative regulation of insulin receptor signaling pathway; positive regulation of NF-kappaB transcription factor activity; cytosol; cytoplasm; nucleus; protein binding; chromatin binding; positive regulation of I-kappaB kinase/NF-kappaB cascade;
BNIP3	8	defense response to virus; cytoplasm; nucleoplasm; nucleus; protein binding; negative regulation of apoptotic process; identical protein binding; virus-host interaction;
IRF9	8	defense response to virus; cytosol; cytoplasm; nucleoplasm; nucleus; protein binding; sequence-specific DNA binding transcription factor activity; cytokine-mediated signaling pathway;
CCND1	8	cytosol; nucleoplasm; nucleus; protein binding; liver development; response to drug; protein kinase binding; protein complex binding;
FOXL1	8	transcription factor complex; nucleus; organ morphogenesis; transcription factor binding; sequence-specific DNA binding transcription factor activity; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; DNA binding; sequence-specific DNA binding;
ARHGEF2	7	cellular response to tumor necrosis factor; nerve growth factor receptor signaling pathway; positive regulation of NF-kappaB transcription factor activity; cytosol; protein binding; transcription factor binding; negative regulation of apoptotic process;
IRF8	7	cellular response to lipopolysaccharide; positive regulation of transcription, DNA-dependent; cytosol; nucleus; protein binding; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; cytokine-mediated signaling pathway;
CDK5RAP2	7	positive regulation of transcription, DNA-dependent; cytosol; cytoplasm; protein binding; transcription regulatory region DNA binding; protein kinase binding; protein complex binding;
MLL	7	positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; nucleus; protein binding; sequence-specific DNA binding transcription factor activity; transcription regulatory region DNA binding; identical protein binding;
MYB	7	positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; protein binding; sequence-specific DNA binding transcription factor activity; DNA binding; chromatin binding;
NCOA6	7	positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; transcription factor complex; nucleoplasm; nucleus; protein binding; chromatin binding;
NUP62	7	positive regulation of transcription, DNA-dependent; cytoplasm; protein binding; chromatin binding; negative regulation of apoptotic process; positive regulation of I-kappaB kinase/NF-kappaB cascade; cytokine-mediated signaling pathway;
RAN	7	positive regulation of transcription, DNA-dependent; cytosol; cytoplasm; nucleoplasm; protein binding; chromatin binding; virus-host interaction;
TBX1	7	positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; nucleus; positive regulation of cell proliferation; sequence-specific DNA binding transcription factor activity; DNA binding; sequence-specific DNA binding;
ZBTB16	7	positive regulation of transcription, DNA-dependent; negative regulation of transcription, DNA-dependent; nucleus; protein binding; DNA binding; identical protein binding; positive regulation of chondrocyte differentiation;
AATF	7	positive regulation of transcription from RNA polymerase II promoter; nerve growth factor receptor signaling pathway; cytoplasm; nucleus; protein binding; sequence-specific DNA binding transcription factor activity; negative regulation of apoptotic process;
FOXD4	7	positive regulation of transcription from RNA polymerase II promoter; transcription factor complex; nucleus; transcription factor binding; sequence-specific DNA binding transcription factor activity; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
MAVS	7	positive regulation of transcription from RNA polymerase II promoter; innate immune response; defense response to virus; protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein kinase binding; virus-host interaction;
PIK3R1	7	positive regulation of transcription from RNA polymerase II promoter; nerve growth factor receptor signaling pathway; T cell receptor signaling pathway; cytosol; protein binding; negative regulation of apoptotic process; virus-host interaction;
POU2F3	7	positive regulation of transcription from RNA polymerase II promoter; cytoplasm; transcription factor complex; nucleus; protein binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
SQSTM1	7	positive regulation of transcription from RNA polymerase II promoter; nerve growth factor receptor signaling pathway; cytosol; nucleoplasm; protein binding; identical protein binding; protein kinase binding;
HERC5	7	innate immune response; defense response to virus; cytosol; cytoplasm; nucleus; protein binding; cytokine-mediated signaling pathway;
BIRC2	7	regulation of inflammatory response; protein N-terminus binding; cytosol; nucleus; protein binding; negative regulation of apoptotic process; positive regulation of I-kappaB kinase/NF-kappaB cascade;
SLC6A3	7	protein N-terminus binding; response to cAMP; cytoplasm; protein binding; aging; response to drug; protein complex binding;
APC	7	cytosol; cytoplasm; nucleus; protein binding; hair follicle development; negative regulation of apoptotic process; protein kinase binding;
CRYAB	7	cytosol; cytoplasm; nucleus; protein binding; aging; response to hydrogen peroxide; negative regulation of apoptotic process;
PARK2	7	cytosol; cytoplasm; nucleus; protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein kinase binding; ubiquitin protein ligase binding;
CYBA	6	cellular response to tumor necrosis factor; innate immune response; response to interleukin-1; inflammatory response; protein binding; response to drug;
ARG1	6	cellular response to lipopolysaccharide; cytosol; cytoplasm; liver development; response to drug; response to amino acid stimulus;
CCR5	6	cellular response to lipopolysaccharide; inflammatory response; cytoplasm; protein binding; cellular defense response; virus-host interaction;
GSTP1	6	cellular response to lipopolysaccharide; cytosol; cytoplasm; nucleus; protein binding; negative regulation of apoptotic process;
IL12B	6	cellular response to lipopolysaccharide; defense response to virus; cytoplasm; protein binding; identical protein binding; response to UV-B;
APBB1	6	positive regulation of transcription, DNA-dependent; cytoplasm; nucleus; protein binding; transcription factor binding; chromatin binding;
HOXA11	6	positive regulation of transcription, DNA-dependent; cytoplasm; transcription factor complex; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding; positive regulation of chondrocyte differentiation;
ID2	6	positive regulation of transcription, DNA-dependent; negative regulation of transcription, DNA-dependent; cytosol; cytoplasm; nucleus; protein binding;
ILK	6	positive regulation of transcription, DNA-dependent; cytosol; cytoplasm; protein binding; positive regulation of cell proliferation; protein kinase binding;
KLF4	6	positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; transcription factor complex; sequence-specific DNA binding transcription factor activity; transcription regulatory region DNA binding;
LHX1	6	positive regulation of transcription, DNA-dependent; negative regulation of transcription, DNA-dependent; nucleus; organ morphogenesis; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
RREB1	6	positive regulation of transcription, DNA-dependent; negative regulation of transcription, DNA-dependent; cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity; DNA binding;
SMARCD3	6	positive regulation of transcription, DNA-dependent; cytoplasm; nucleoplasm; nucleus; protein binding; transcription factor binding;
SPI1	6	positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; protein binding; sequence-specific DNA binding transcription factor activity; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity;
TP53BP1	6	positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; cytoplasm; nucleoplasm; nucleus; protein binding;
BSX	6	positive regulation of transcription from RNA polymerase II promoter; cytoplasm; transcription factor complex; nucleus; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
ESRRA	6	positive regulation of transcription from RNA polymerase II promoter; nucleoplasm; nucleus; protein binding; DNA binding; sequence-specific DNA binding;
HOXA13	6	positive regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity; DNA binding; sequence-specific DNA binding; transcription regulatory region DNA binding;
HOXA5	6	positive regulation of transcription from RNA polymerase II promoter; nucleus; protein binding; sequence-specific DNA binding transcription factor activity; DNA binding; sequence-specific DNA binding;
HOXA7	6	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nucleus; transcription factor binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
HOXB1	6	positive regulation of transcription from RNA polymerase II promoter; cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity; DNA binding; sequence-specific DNA binding;
IKZF1	6	positive regulation of transcription from RNA polymerase II promoter; cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity; DNA binding; sequence-specific DNA binding;
ISL1	6	positive regulation of transcription from RNA polymerase II promoter; cytoplasm; nucleus; positive regulation of cell proliferation; sequence-specific DNA binding transcription factor activity; chromatin binding;
MEIS2	6	positive regulation of transcription from RNA polymerase II promoter; nucleus; protein binding; transcription factor binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
NCK1	6	positive regulation of transcription from RNA polymerase II promoter; T cell receptor signaling pathway; cytosol; cytoplasm; nucleus; protein binding;
NFATC4	6	positive regulation of transcription from RNA polymerase II promoter; inflammatory response; cytosol; cytoplasm; transcription factor complex; DNA binding;
NR4A2	6	positive regulation of transcription from RNA polymerase II promoter; cytoplasm; nucleoplasm; nucleus; protein binding; sequence-specific DNA binding;
ONECUT2	6	positive regulation of transcription from RNA polymerase II promoter; nucleus; organ morphogenesis; liver development; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
RPS6KA4	6	positive regulation of transcription from RNA polymerase II promoter; positive regulation of NF-kappaB transcription factor activity; inflammatory response; cytoplasm; nucleus; protein binding;
SNW1	6	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; nucleoplasm; nucleus; protein binding; virus-host interaction;
TFEB	6	positive regulation of transcription from RNA polymerase II promoter; cytoplasm; transcription factor complex; nucleus; sequence-specific DNA binding transcription factor activity; transcription regulatory region DNA binding;
UBE3A	6	positive regulation of transcription from RNA polymerase II promoter; cytosol; cytoplasm; nucleus; protein binding; virus-host interaction;
VEGFA	6	positive regulation of transcription from RNA polymerase II promoter; cytoplasm; protein binding; positive regulation of cell proliferation; negative regulation of apoptotic process; identical protein binding;
PIK3CG	6	innate immune response; inflammatory response; cytosol; cytoplasm; protein binding; negative regulation of apoptotic process;
RIPK3	6	innate immune response; positive regulation of NF-kappaB transcription factor activity; cytosol; protein binding; identical protein binding; positive regulation of type I interferon production;
SYK	6	innate immune response; cytosol; protein binding; organ morphogenesis; protein kinase binding; virus-host interaction;
TRIM32	6	innate immune response; positive regulation of NF-kappaB transcription factor activity; cytoplasm; nucleus; protein binding; negative regulation of apoptotic process;
CREBZF	6	negative regulation of transcription, DNA-dependent; nucleus; protein binding; sequence-specific DNA binding transcription factor activity; DNA binding; sequence-specific DNA binding;
ZNF24	6	negative regulation of transcription, DNA-dependent; nucleus; protein binding; sequence-specific DNA binding transcription factor activity; DNA binding; sequence-specific DNA binding;
ADAM17	6	nerve growth factor receptor signaling pathway; cytoplasm; protein binding; positive regulation of cell proliferation; response to drug; membrane protein intracellular domain proteolysis;
BCAR1	6	nerve growth factor receptor signaling pathway; T cell receptor signaling pathway; cytosol; cytoplasm; protein binding; protein kinase binding;
BIRC3	6	regulation of inflammatory response; cytoplasm; nucleus; protein binding; negative regulation of apoptotic process; positive regulation of I-kappaB kinase/NF-kappaB cascade;
INPPL1	6	negative regulation of insulin receptor signaling pathway; cytosol; cytoplasm; protein binding; response to drug; response to insulin stimulus;
ATM	6	protein N-terminus binding; nucleoplasm; protein binding; DNA binding; negative regulation of apoptotic process; protein complex binding;
NCOR2	6	protein N-terminus binding; nucleoplasm; nucleus; protein binding; DNA binding; chromatin binding;
TERF2IP	6	positive regulation of NF-kappaB transcription factor activity; cytoplasm; nucleoplasm; nucleus; protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade;
PAK1	6	T cell receptor signaling pathway; cytosol; cytoplasm; protein binding; identical protein binding; protein kinase binding;
RPS3	6	NF-kappaB binding; cytosol; cytoplasm; nucleus; protein binding; protein kinase binding;
TAF4B	6	NF-kappaB binding; cytoplasm; nucleoplasm; nucleus; sequence-specific DNA binding transcription factor activity; DNA binding;
ARRB2	6	cytosol; cytoplasm; nucleus; protein binding; ubiquitin protein ligase binding; protein complex binding;
CBL	6	cytosol; cytoplasm; nucleus; protein binding; sequence-specific DNA binding transcription factor activity; negative regulation of apoptotic process;
NEDD4L	6	cytosol; cytoplasm; nucleoplasm; nucleus; protein binding; virus-host interaction;
PLK1	6	cytosol; nucleoplasm; nucleus; protein binding; negative regulation of apoptotic process; protein kinase binding;
PRKAA1	6	cytosol; nucleus; protein binding; positive regulation of cell proliferation; chromatin binding; negative regulation of apoptotic process;
PSMC3	6	cytosol; cytoplasm; nucleoplasm; nucleus; protein binding; virus-host interaction;
XPO1	6	cytosol; cytoplasm; nucleoplasm; protein binding; response to drug; virus-host interaction;
DDB1	6	cytoplasm; nucleoplasm; nucleus; protein binding; DNA binding; virus-host interaction;
HOXA9	6	cytoplasm; transcription factor complex; nucleus; protein binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
MTA3	6	cytoplasm; nucleus; positive regulation of cell proliferation; sequence-specific DNA binding transcription factor activity; chromatin binding; sequence-specific DNA binding;
PGR	6	cytoplasm; nucleoplasm; nucleus; protein binding; DNA binding; sequence-specific DNA binding;
SSRP1	6	cytoplasm; nucleoplasm; nucleus; protein binding; DNA binding; chromatin binding;
ZFPM1	6	cytoplasm; transcription factor complex; nucleoplasm; protein binding; transcription factor binding; DNA binding;
CREB5	5	positive regulation of transcription, DNA-dependent; nucleus; protein binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
DAB2	5	positive regulation of transcription, DNA-dependent; negative regulation of transcription, DNA-dependent; nucleus; protein binding; negative regulation of apoptotic process;
LHX2	5	positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; nucleus; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
MED12	5	positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; nucleoplasm; nucleus; chromatin binding;
MED17	5	positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; transcription factor complex; nucleoplasm; nucleus;
NPAT	5	positive regulation of transcription, DNA-dependent; protein N-terminus binding; nucleus; protein binding; sequence-specific DNA binding transcription factor activity;
RNF20	5	positive regulation of transcription, DNA-dependent; nucleus; protein binding; chromatin binding; ubiquitin protein ligase binding;
RSF1	5	positive regulation of transcription, DNA-dependent; negative regulation of transcription, DNA-dependent; nucleoplasm; nucleus; protein binding;
WNT11	5	positive regulation of transcription, DNA-dependent; negative regulation of transcription, DNA-dependent; cytoplasm; transcription regulatory region DNA binding; negative regulation of apoptotic process;
ZNF423	5	positive regulation of transcription, DNA-dependent; negative regulation of transcription, DNA-dependent; nucleus; protein binding; DNA binding;
ARID3C	5	positive regulation of transcription from RNA polymerase II promoter; cytoplasm; nucleus; DNA binding; chromatin binding;
BARX2	5	positive regulation of transcription from RNA polymerase II promoter; transcription factor complex; sequence-specific DNA binding transcription factor activity; DNA binding; chromatin binding;
CBFA2T3	5	positive regulation of transcription from RNA polymerase II promoter; nucleoplasm; protein binding; sequence-specific DNA binding transcription factor activity; chromatin binding;
CLOCK	5	positive regulation of transcription from RNA polymerase II promoter; cytosol; transcription factor complex; nucleus; sequence-specific DNA binding transcription factor activity;
DRD3	5	positive regulation of transcription from RNA polymerase II promoter; protein binding; positive regulation of cell proliferation; response to drug; response to morphine;
FGF4	5	positive regulation of transcription from RNA polymerase II promoter; cytosol; nucleus; positive regulation of cell proliferation; negative regulation of apoptotic process;
FLCN	5	positive regulation of transcription from RNA polymerase II promoter; cytoplasm; nucleus; protein binding; protein complex binding;
GREM1	5	positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of NF-kappaB transcription factor activity; protein binding; positive regulation of cell proliferation;
HOXA1	5	positive regulation of transcription from RNA polymerase II promoter; nucleus; protein binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
LPIN1	5	positive regulation of transcription from RNA polymerase II promoter; cytosol; cytoplasm; transcription factor complex; nucleus;
MAF	5	positive regulation of transcription from RNA polymerase II promoter; cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
MAML1	5	positive regulation of transcription from RNA polymerase II promoter; nucleoplasm; nucleus; protein binding; protein kinase binding;
NPAS2	5	positive regulation of transcription from RNA polymerase II promoter; cytosol; transcription factor complex; sequence-specific DNA binding transcription factor activity; DNA binding;
RORA	5	positive regulation of transcription from RNA polymerase II promoter; nucleoplasm; protein binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
SMARCB1	5	positive regulation of transcription from RNA polymerase II promoter; nucleoplasm; nucleus; protein binding; virus-host interaction;
WWOX	5	positive regulation of transcription from RNA polymerase II promoter; cytosol; cytoplasm; nucleus; protein binding;
ATG5	5	innate immune response; cytoplasm; protein binding; response to drug; negative regulation of apoptotic process;
MAP3K5	5	innate immune response; protein binding; identical protein binding; protein kinase binding; virus-host interaction;
MIF	5	innate immune response; inflammatory response; cytoplasm; protein binding; negative regulation of apoptotic process;
BCLAF1	5	negative regulation of transcription, DNA-dependent; cytoplasm; nucleus; protein binding; DNA binding;
BRMS1	5	negative regulation of transcription, DNA-dependent; NF-kappaB binding; cytoplasm; nucleus; protein binding;
EED	5	negative regulation of transcription, DNA-dependent; nucleus; protein binding; chromatin binding; identical protein binding;
EREG	5	negative regulation of transcription, DNA-dependent; protein binding; organ morphogenesis; positive regulation of cell proliferation; cytokine-mediated signaling pathway;
HSPA8	5	negative regulation of transcription, DNA-dependent; cytosol; nucleus; protein binding; virus-host interaction;
NIPBL	5	negative regulation of transcription, DNA-dependent; protein N-terminus binding; nucleus; protein binding; chromatin binding;
PDCD4	5	negative regulation of transcription, DNA-dependent; cytosol; cytoplasm; nucleus; protein binding;
RCOR2	5	negative regulation of transcription, DNA-dependent; transcription factor complex; sequence-specific DNA binding transcription factor activity; DNA binding; chromatin binding;
WWP1	5	negative regulation of transcription, DNA-dependent; cytosol; cytoplasm; nucleus; protein binding;
ZNF263	5	negative regulation of transcription, DNA-dependent; cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity; DNA binding;
ADORA2A	5	nerve growth factor receptor signaling pathway; inflammatory response; protein binding; cellular defense response; response to drug;
GRB10	5	negative regulation of insulin receptor signaling pathway; cytosol; cytoplasm; protein binding; response to insulin stimulus;
PDCD10	5	protein N-terminus binding; cytosol; protein binding; positive regulation of cell proliferation; negative regulation of apoptotic process;
TSC1	5	protein N-terminus binding; cytosol; cytoplasm; protein binding; response to insulin stimulus;
INS	5	positive regulation of NF-kappaB transcription factor activity; protein binding; positive regulation of cell proliferation; negative regulation of protein catabolic process; negative regulation of apoptotic process;
RNF31	5	positive regulation of NF-kappaB transcription factor activity; T cell receptor signaling pathway; cytoplasm; protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade;
TNFRSF11A	5	positive regulation of NF-kappaB transcription factor activity; response to interleukin-1; protein binding; positive regulation of cell proliferation; positive regulation of I-kappaB kinase/NF-kappaB cascade;
TRAF1	5	positive regulation of NF-kappaB transcription factor activity; cytoplasm; protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade; ubiquitin protein ligase binding;
ALDH3A1	5	response to cAMP; cytosol; positive regulation of cell proliferation; aging; response to drug;
FYB	5	T cell receptor signaling pathway; cytosol; nucleus; protein binding; protein complex binding;
GHR	5	response to interleukin-1; nucleus; protein binding; response to morphine; protein kinase binding;
OASL	5	defense response to virus; cytosol; cytoplasm; DNA binding; cytokine-mediated signaling pathway;
TRIM22	5	defense response to virus; cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity; virus-host interaction;
AIP	5	cytosol; cytoplasm; nucleus; protein binding; transcription factor binding;
BAIAP2	5	cytosol; cytoplasm; nucleus; protein binding; identical protein binding;
BANF1	5	cytosol; nucleoplasm; protein binding; DNA binding; virus-host interaction;
BLMH	5	cytosol; cytoplasm; nucleus; protein binding; response to drug;
CDT1	5	cytosol; nucleoplasm; nucleus; protein binding; DNA binding;
CUL5	5	cytosol; nucleus; protein binding; ubiquitin protein ligase binding; virus-host interaction;
EEF1D	5	cytosol; nucleus; protein binding; DNA binding; positive regulation of I-kappaB kinase/NF-kappaB cascade;
EGLN3	5	cytosol; cytoplasm; nucleoplasm; nucleus; protein binding;
FANCC	5	cytosol; cytoplasm; nucleoplasm; nucleus; protein binding;
HTR2A	5	cytosol; positive regulation of cell proliferation; aging; response to drug; protein complex binding;
MAP1S	5	cytosol; nucleus; protein binding; DNA binding; identical protein binding;
NCBP1	5	cytosol; nucleoplasm; nucleus; protein binding; DNA binding;
NUMA1	5	cytosol; cytoplasm; nucleoplasm; nucleus; protein binding;
PAFAH1B1	5	cytosol; cytoplasm; nucleus; protein binding; protein complex binding;
PTTG1	5	cytosol; cytoplasm; nucleus; protein binding; sequence-specific DNA binding transcription factor activity;
RFWD2	5	cytosol; cytoplasm; nucleoplasm; nucleus; protein binding;
RPTOR	5	cytosol; cytoplasm; protein binding; protein kinase binding; protein complex binding;
SART1	5	cytosol; cytoplasm; nucleoplasm; nucleus; protein binding;
TCEB1	5	cytosol; nucleoplasm; protein binding; virus-host interaction; protein complex binding;
TH	5	cytosol; cytoplasm; nucleus; protein binding; organ morphogenesis;
TJP1	5	cytosol; cytoplasm; nucleus; protein binding; response to drug;
CFL1	5	cytoplasm; nucleus; protein binding; negative regulation of apoptotic process; response to amino acid stimulus;
DEAF1	5	cytoplasm; transcription factor complex; nucleus; protein binding; DNA binding;
DHX9	5	cytoplasm; nucleoplasm; nucleus; protein binding; DNA binding;
FLT4	5	cytoplasm; nucleus; protein binding; positive regulation of cell proliferation; negative regulation of apoptotic process;
FUS	5	cytoplasm; nucleoplasm; nucleus; protein binding; DNA binding;
IGHMBP2	5	cytoplasm; nucleus; protein binding; transcription factor binding; DNA binding;
NEK6	5	cytoplasm; nucleus; protein binding; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein kinase binding;
PKNOX2	5	cytoplasm; nucleus; sequence-specific DNA binding transcription factor activity; DNA binding; sequence-specific DNA binding;
PRC1	5	cytoplasm; nucleus; protein binding; identical protein binding; protein kinase binding;
PRPF19	5	cytoplasm; nucleus; protein binding; DNA binding; identical protein binding;
RAD9A	5	cytoplasm; nucleoplasm; nucleus; protein binding; protein kinase binding;
RCC1	5	cytoplasm; nucleoplasm; nucleus; protein binding; chromatin binding;
RNF40	5	cytoplasm; nucleus; protein binding; ubiquitin protein ligase binding; protein complex binding;
SMC1A	5	cytoplasm; nucleoplasm; nucleus; protein binding; chromatin binding;
SMC3	5	cytoplasm; nucleoplasm; nucleus; protein binding; chromatin binding;
TAF10	5	cytoplasm; nucleoplasm; nucleus; protein binding; sequence-specific DNA binding transcription factor activity;
TCF25	5	cytoplasm; nucleus; protein binding; sequence-specific DNA binding transcription factor activity; DNA binding;
NR4A3	5	transcription factor complex; nucleoplasm; nucleus; DNA binding; sequence-specific DNA binding;
ATF6	5	nucleoplasm; nucleus; protein binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding;
PALB2	5	nucleoplasm; protein binding; organ morphogenesis; DNA binding; negative regulation of apoptotic process;
TAF13	5	nucleoplasm; nucleus; protein binding; sequence-specific DNA binding transcription factor activity; DNA binding;
DRAP1	5	nucleus; transcription factor binding; sequence-specific DNA binding transcription factor activity; DNA binding; sequence-specific DNA binding;

Genes shared at least 2 KEGG pathways with RELA (count: 109)

Gene Symbol	Pathway Count	Pathway List
MAPK1	19	Pathways in cancer; Tuberculosis; Shigellosis; T cell receptor signaling pathway; MAPK signaling pathway; Osteoclast differentiation; Chemokine signaling pathway; Leishmaniasis; Toxoplasmosis; Neurotrophin signaling pathway; B cell receptor signaling pathway; Acute myeloid leukemia; Chronic myeloid leukemia; Prostate cancer; Pancreatic cancer; Hepatitis C; NOD-like receptor signaling pathway; Chagas disease (American trypanosomiasis); Toll-like receptor signaling pathway;
MAPK3	19	Pathways in cancer; Tuberculosis; Shigellosis; T cell receptor signaling pathway; MAPK signaling pathway; Osteoclast differentiation; Chemokine signaling pathway; Leishmaniasis; Toxoplasmosis; Neurotrophin signaling pathway; B cell receptor signaling pathway; Acute myeloid leukemia; Chronic myeloid leukemia; Prostate cancer; Pancreatic cancer; Hepatitis C; NOD-like receptor signaling pathway; Chagas disease (American trypanosomiasis); Toll-like receptor signaling pathway;
PIK3CG	18	Pathways in cancer; Amoebiasis; Apoptosis; T cell receptor signaling pathway; Measles; Osteoclast differentiation; Chemokine signaling pathway; Toxoplasmosis; Neurotrophin signaling pathway; B cell receptor signaling pathway; Acute myeloid leukemia; Chronic myeloid leukemia; Prostate cancer; Pancreatic cancer; Hepatitis C; Small cell lung cancer; Chagas disease (American trypanosomiasis); Toll-like receptor signaling pathway;
PIK3R1	18	Pathways in cancer; Amoebiasis; Apoptosis; T cell receptor signaling pathway; Measles; Osteoclast differentiation; Chemokine signaling pathway; Toxoplasmosis; Neurotrophin signaling pathway; B cell receptor signaling pathway; Acute myeloid leukemia; Chronic myeloid leukemia; Prostate cancer; Pancreatic cancer; Hepatitis C; Small cell lung cancer; Chagas disease (American trypanosomiasis); Toll-like receptor signaling pathway;
MAPK9	16	Pathways in cancer; Tuberculosis; Shigellosis; RIG-I-like receptor signaling pathway; T cell receptor signaling pathway; MAPK signaling pathway; Epithelial cell signaling in Helicobacter pylori infection; Osteoclast differentiation; Toxoplasmosis; Neurotrophin signaling pathway; Adipocytokine signaling pathway; Pancreatic cancer; Hepatitis C; NOD-like receptor signaling pathway; Chagas disease (American trypanosomiasis); Toll-like receptor signaling pathway;
BAD	10	Pathways in cancer; Tuberculosis; Apoptosis; Toxoplasmosis; Neurotrophin signaling pathway; Acute myeloid leukemia; Chronic myeloid leukemia; Prostate cancer; Pancreatic cancer; Hepatitis C;
GSK3B	8	Pathways in cancer; T cell receptor signaling pathway; Measles; Chemokine signaling pathway; Neurotrophin signaling pathway; B cell receptor signaling pathway; Prostate cancer; Hepatitis C;
IL6	8	Pathways in cancer; Tuberculosis; Amoebiasis; Cytosolic DNA-sensing pathway; Measles; NOD-like receptor signaling pathway; Chagas disease (American trypanosomiasis); Toll-like receptor signaling pathway;
IL12B	8	Tuberculosis; RIG-I-like receptor signaling pathway; Amoebiasis; Measles; Leishmaniasis; Toxoplasmosis; Chagas disease (American trypanosomiasis); Toll-like receptor signaling pathway;
CCND1	7	Pathways in cancer; Measles; Acute myeloid leukemia; Chronic myeloid leukemia; Prostate cancer; Pancreatic cancer; Small cell lung cancer;
TLR4	7	Tuberculosis; Amoebiasis; Measles; Leishmaniasis; Toxoplasmosis; Chagas disease (American trypanosomiasis); Toll-like receptor signaling pathway;
CRKL	6	Pathways in cancer; Shigellosis; MAPK signaling pathway; Chemokine signaling pathway; Neurotrophin signaling pathway; Chronic myeloid leukemia;
FADD	6	Pathways in cancer; Tuberculosis; RIG-I-like receptor signaling pathway; Apoptosis; Chagas disease (American trypanosomiasis); Toll-like receptor signaling pathway;
PRKCB	6	Pathways in cancer; Amoebiasis; MAPK signaling pathway; Chemokine signaling pathway; Leishmaniasis; B cell receptor signaling pathway;
TGFBR1	6	Pathways in cancer; MAPK signaling pathway; Osteoclast differentiation; Chronic myeloid leukemia; Pancreatic cancer; Chagas disease (American trypanosomiasis);
IFNGR1	6	Tuberculosis; Measles; Osteoclast differentiation; Leishmaniasis; Toxoplasmosis; Chagas disease (American trypanosomiasis);
BIRC2	5	Pathways in cancer; Apoptosis; Toxoplasmosis; Small cell lung cancer; NOD-like receptor signaling pathway;
BIRC3	5	Pathways in cancer; Apoptosis; Toxoplasmosis; Small cell lung cancer; NOD-like receptor signaling pathway;
CYCS	5	Pathways in cancer; Tuberculosis; Apoptosis; Toxoplasmosis; Small cell lung cancer;
PLCG2	5	Pathways in cancer; Epithelial cell signaling in Helicobacter pylori infection; Osteoclast differentiation; Neurotrophin signaling pathway; B cell receptor signaling pathway;
PPP3R2	5	Tuberculosis; Apoptosis; T cell receptor signaling pathway; MAPK signaling pathway; B cell receptor signaling pathway;
IRF7	5	RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; Measles; Hepatitis C; Toll-like receptor signaling pathway;
LAMA2	4	Pathways in cancer; Amoebiasis; Toxoplasmosis; Small cell lung cancer;
LAMA3	4	Pathways in cancer; Amoebiasis; Toxoplasmosis; Small cell lung cancer;
LAMC1	4	Pathways in cancer; Amoebiasis; Toxoplasmosis; Small cell lung cancer;
LAMC2	4	Pathways in cancer; Amoebiasis; Toxoplasmosis; Small cell lung cancer;
FCGR2B	4	Tuberculosis; Measles; Osteoclast differentiation; B cell receptor signaling pathway;
MAVS	4	RIG-I-like receptor signaling pathway; Cytosolic DNA-sensing pathway; Measles; Hepatitis C;
PAK1	4	T cell receptor signaling pathway; MAPK signaling pathway; Epithelial cell signaling in Helicobacter pylori infection; Chemokine signaling pathway;
CBL	3	Pathways in cancer; T cell receptor signaling pathway; Chronic myeloid leukemia;
ERBB2	3	Pathways in cancer; Prostate cancer; Pancreatic cancer;
FN1	3	Pathways in cancer; Amoebiasis; Small cell lung cancer;
SPI1	3	Pathways in cancer; Osteoclast differentiation; Acute myeloid leukemia;
FCGR2A	3	Tuberculosis; Osteoclast differentiation; Leishmaniasis;
FCGR2C	3	Tuberculosis; Osteoclast differentiation; Leishmaniasis;
FCGR3A	3	Tuberculosis; Osteoclast differentiation; Leishmaniasis;
FCGR3B	3	Tuberculosis; Osteoclast differentiation; Leishmaniasis;
HLA-DRB1	3	Tuberculosis; Leishmaniasis; Toxoplasmosis;
IL18	3	Tuberculosis; Cytosolic DNA-sensing pathway; NOD-like receptor signaling pathway;
MALT1	3	Tuberculosis; T cell receptor signaling pathway; B cell receptor signaling pathway;
SYK	3	Tuberculosis; Osteoclast differentiation; B cell receptor signaling pathway;
PLCB2	3	Amoebiasis; Chemokine signaling pathway; Chagas disease (American trypanosomiasis);
PLCB3	3	Amoebiasis; Chemokine signaling pathway; Chagas disease (American trypanosomiasis);
NGF	3	Apoptosis; MAPK signaling pathway; Neurotrophin signaling pathway;
CD3D	3	T cell receptor signaling pathway; Measles; Chagas disease (American trypanosomiasis);
CD3E	3	T cell receptor signaling pathway; Measles; Chagas disease (American trypanosomiasis);
CD3G	3	T cell receptor signaling pathway; Measles; Chagas disease (American trypanosomiasis);
NFATC4	3	T cell receptor signaling pathway; MAPK signaling pathway; B cell receptor signaling pathway;
HSPA6	3	MAPK signaling pathway; Measles; Toxoplasmosis;
HSPA8	3	MAPK signaling pathway; Measles; Toxoplasmosis;
MAP2K3	3	MAPK signaling pathway; Toxoplasmosis; Toll-like receptor signaling pathway;
IRF9	3	Measles; Osteoclast differentiation; Hepatitis C;
SHC3	3	Chemokine signaling pathway; Neurotrophin signaling pathway; Chronic myeloid leukemia;
FGF10	2	Pathways in cancer; MAPK signaling pathway;
FGF19	2	Pathways in cancer; MAPK signaling pathway;
FGF3	2	Pathways in cancer; MAPK signaling pathway;
FGF4	2	Pathways in cancer; MAPK signaling pathway;
FGF9	2	Pathways in cancer; MAPK signaling pathway;
GSTP1	2	Pathways in cancer; Prostate cancer;
ITGA2	2	Pathways in cancer; Small cell lung cancer;
PLD1	2	Pathways in cancer; Pancreatic cancer;
SKP2	2	Pathways in cancer; Small cell lung cancer;
TRAF1	2	Pathways in cancer; Small cell lung cancer;
VEGFA	2	Pathways in cancer; Pancreatic cancer;
VEGFB	2	Pathways in cancer; Pancreatic cancer;
ZBTB16	2	Pathways in cancer; Acute myeloid leukemia;
ATP6V0A2	2	Tuberculosis; Epithelial cell signaling in Helicobacter pylori infection;
ATP6V0D2	2	Tuberculosis; Epithelial cell signaling in Helicobacter pylori infection;
CAMK2D	2	Tuberculosis; Neurotrophin signaling pathway;
IL10RA	2	Tuberculosis; Toxoplasmosis;
TCIRG1	2	Tuberculosis; Epithelial cell signaling in Helicobacter pylori infection;
TIRAP	2	Tuberculosis; Toll-like receptor signaling pathway;
ATG5	2	Shigellosis; RIG-I-like receptor signaling pathway;
ROCK2	2	Shigellosis; Chemokine signaling pathway;
WASL	2	Shigellosis; Chemokine signaling pathway;
GNAL	2	Amoebiasis; Chagas disease (American trypanosomiasis);
CASP1	2	Cytosolic DNA-sensing pathway; NOD-like receptor signaling pathway;
PYCARD	2	Cytosolic DNA-sensing pathway; NOD-like receptor signaling pathway;
ITK	2	T cell receptor signaling pathway; Chemokine signaling pathway;
ARRB1	2	MAPK signaling pathway; Chemokine signaling pathway;
ARRB2	2	MAPK signaling pathway; Chemokine signaling pathway;
BDNF	2	MAPK signaling pathway; Neurotrophin signaling pathway;
MAP3K5	2	MAPK signaling pathway; Neurotrophin signaling pathway;
MAPK7	2	MAPK signaling pathway; Neurotrophin signaling pathway;
NTF3	2	MAPK signaling pathway; Neurotrophin signaling pathway;
NTRK2	2	MAPK signaling pathway; Neurotrophin signaling pathway;
PLA2G10	2	MAPK signaling pathway; Toxoplasmosis;
PLA2G1B	2	MAPK signaling pathway; Toxoplasmosis;
PLA2G2A	2	MAPK signaling pathway; Toxoplasmosis;
PLA2G2D	2	MAPK signaling pathway; Toxoplasmosis;
PLA2G2E	2	MAPK signaling pathway; Toxoplasmosis;
PLA2G3	2	MAPK signaling pathway; Toxoplasmosis;
PLA2G4B	2	MAPK signaling pathway; Toxoplasmosis;
PLA2G5	2	MAPK signaling pathway; Toxoplasmosis;
PLA2G6	2	MAPK signaling pathway; Toxoplasmosis;
RASGRP2	2	MAPK signaling pathway; Chemokine signaling pathway;
RPS6KA4	2	MAPK signaling pathway; Neurotrophin signaling pathway;
TNFAIP3	2	Measles; NOD-like receptor signaling pathway;
CXCR1	2	Epithelial cell signaling in Helicobacter pylori infection; Chemokine signaling pathway;
CXCR2	2	Epithelial cell signaling in Helicobacter pylori infection; Chemokine signaling pathway;
CYBA	2	Osteoclast differentiation; Leishmaniasis;
GAB2	2	Osteoclast differentiation; Chronic myeloid leukemia;
LILRB3	2	Osteoclast differentiation; B cell receptor signaling pathway;
NCF2	2	Osteoclast differentiation; Leishmaniasis;
CCR5	2	Chemokine signaling pathway; Toxoplasmosis;
GNAO1	2	Toxoplasmosis; Chagas disease (American trypanosomiasis);
PPP2R1B	2	Hepatitis C; Chagas disease (American trypanosomiasis);
PPP2R2C	2	Hepatitis C; Chagas disease (American trypanosomiasis);
PPP2R2D	2	Hepatitis C; Chagas disease (American trypanosomiasis);

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Region: chr11:65421067..65430565 View in gBrowse