ADHDgene Database

Hot Results

Quick Search

Keyword:
Type:

Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	CDH2
Previous Symbol	NCAD
Symbol Alias	CDHN, CD325
Approved Name	cadherin 2, type 1, N-cadherin (neuronal)
Name Alias	N-cadherin
Location	18q12.1
Position	chr18:25530930-25757445, -
External Links	HGNC: 1759 Entrez Gene: 1000 Ensembl: ENSG00000170558 UCSC: uc002kwg.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
18q11.2-12.3	chr18:19000000-43500000	1 (1/0/0)

Gene related GO terms (count: 28)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 28)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0005911	cell-cell junction	Cellular Component	IDA[7650039]	20
GO:0005913	cell-cell adherens junction	Cellular Component	IDA[19101069]	9
GO:0005509	calcium ion binding	Molecular Function		124
GO:0005886	plasma membrane	Cellular Component		772
GO:0016339	calcium-dependent cell-cell adhesion	Biological Process		8
GO:0016021	integral to membrane	Cellular Component		845
GO:0014704	intercalated disc	Cellular Component		10
GO:0008013	beta-catenin binding	Molecular Function	TAS[16344550]	10
GO:0007157	heterophilic cell-cell adhesion	Biological Process		11
GO:0007156	homophilic cell adhesion	Biological Process		27
GO:0007155	cell adhesion	Biological Process	TAS[2384753]	86
GO:0005916	fascia adherens	Cellular Component		4
GO:0043410	positive regulation of MAPK cascade	Biological Process		17
GO:0042692	muscle cell differentiation	Biological Process		8
GO:0034332	adherens junction organization	Biological Process		9
GO:0034329	cell junction assembly	Biological Process		13
GO:0030027	lamellipodium	Cellular Component		27
GO:0019903	protein phosphatase binding	Molecular Function		12
GO:0016477	cell migration	Biological Process		24
GO:0016342	catenin complex	Cellular Component	IDA[7650039]	1
GO:0045295	gamma-catenin binding	Molecular Function	IPI[7650039]	6
GO:0045294	alpha-catenin binding	Molecular Function	IPI[7650039]	1
GO:0045216	cell-cell junction organization	Biological Process		10
GO:0045202	synapse	Cellular Component		31
GO:0090090	negative regulation of canonical Wnt receptor signaling pathway	Biological Process		14
GO:0051149	positive regulation of muscle cell differentiation	Biological Process		5
GO:0051146	striated muscle cell differentiation	Biological Process		2
GO:0048514	blood vessel morphogenesis	Biological Process		4

Gene related KEGG pathways (count: 2)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04514	Cell adhesion molecules (CAMs)	20	Cell adhesion molecules are (glyco)proteins expressed on the...... Cell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes. More...
hsa05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27	Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an...... Arrhythmogenic right ventricular cardiomyopathy (ARVC) is an inherited heart muscle disease that may result in arrhythmia, heart failure, and sudden death. The hallmark pathological findings are progressive myocyte loss and fibrofatty replacement, with a predilection for the right ventricle. A number of genetic studies have identified mutations in various components of the cardiac desmosome that have important roles in the pathogenesis of ARVC. Disruption of desmosomal function by defective proteins might lead to death of myocytes under mechanical stress. The myocardial injury may be accompanied by inflammation. Since regeneration of cardiac myocytes is limited, repair by fibrofatty replacement occurs. Several studies have implicated that desmosome dysfunction results in the delocalization and nuclear translocation of plakoglobin. As a result, competition between plakoglobin and beta-catenin will lead to the inhibition of Wnt/beta-catenin signaling, resulting in a shift from a myocyte fate towards an adipocyte fate of cells. The ryanodine receptor plays a crucial part in electromechanical coupling by control of release of calcium from the sarcoplasmic reticulum into the cytosol. Therefore, defects in this receptor could result in an imbalance of calcium homeostasis that might trigger cell death. More...

Genes shared at least 5 GO terms with CDH2 (count: 19)

Gene Symbol	Pathway Count	Pathway List
CTNND1	10	cell-cell junction; cell-cell adherens junction; plasma membrane; cell adhesion; adherens junction organization; cell junction assembly; lamellipodium; protein phosphatase binding; cell-cell junction organization; negative regulation of canonical Wnt receptor signaling pathway;
CDH15	10	calcium ion binding; plasma membrane; integral to membrane; homophilic cell adhesion; cell adhesion; muscle cell differentiation; adherens junction organization; cell junction assembly; cell-cell junction organization; positive regulation of muscle cell differentiation;
PVRL1	9	cell-cell adherens junction; plasma membrane; integral to membrane; heterophilic cell-cell adhesion; homophilic cell adhesion; cell adhesion; adherens junction organization; cell junction assembly; cell-cell junction organization;
CADM1	8	cell-cell junction; plasma membrane; integral to membrane; heterophilic cell-cell adhesion; homophilic cell adhesion; adherens junction organization; cell junction assembly; cell-cell junction organization;
APC	8	cell-cell adherens junction; plasma membrane; beta-catenin binding; cell adhesion; lamellipodium; cell migration; gamma-catenin binding; negative regulation of canonical Wnt receptor signaling pathway;
CDH4	8	calcium ion binding; plasma membrane; heterophilic cell-cell adhesion; homophilic cell adhesion; cell adhesion; adherens junction organization; cell junction assembly; cell-cell junction organization;
CDH6	8	calcium ion binding; plasma membrane; integral to membrane; homophilic cell adhesion; cell adhesion; adherens junction organization; cell junction assembly; cell-cell junction organization;
DSC3	7	cell-cell junction; calcium ion binding; plasma membrane; integral to membrane; homophilic cell adhesion; cell adhesion; gamma-catenin binding;
DSG1	7	cell-cell junction; calcium ion binding; plasma membrane; calcium-dependent cell-cell adhesion; integral to membrane; homophilic cell adhesion; gamma-catenin binding;
CDH12	7	calcium ion binding; plasma membrane; integral to membrane; homophilic cell adhesion; adherens junction organization; cell junction assembly; cell-cell junction organization;
CDH13	7	calcium ion binding; plasma membrane; calcium-dependent cell-cell adhesion; homophilic cell adhesion; adherens junction organization; cell junction assembly; cell-cell junction organization;
DSG2	6	cell-cell junction; calcium ion binding; plasma membrane; integral to membrane; homophilic cell adhesion; cell adhesion;
PTPRK	6	cell-cell junction; integral to membrane; beta-catenin binding; cell adhesion; cell migration; gamma-catenin binding;
DSC2	6	cell-cell adherens junction; calcium ion binding; plasma membrane; integral to membrane; homophilic cell adhesion; cell adhesion;
CDHR5	6	calcium ion binding; plasma membrane; calcium-dependent cell-cell adhesion; integral to membrane; homophilic cell adhesion; cell adhesion;
CDON	6	plasma membrane; integral to membrane; cell adhesion; positive regulation of MAPK cascade; muscle cell differentiation; positive regulation of muscle cell differentiation;
CDH23	5	calcium ion binding; plasma membrane; calcium-dependent cell-cell adhesion; integral to membrane; homophilic cell adhesion;
DCHS1	5	calcium ion binding; plasma membrane; calcium-dependent cell-cell adhesion; integral to membrane; homophilic cell adhesion;
NRXN1	5	plasma membrane; calcium-dependent cell-cell adhesion; integral to membrane; heterophilic cell-cell adhesion; cell adhesion;

Genes shared at least 2 KEGG pathways with CDH2 (count: 0)

View in gBrowse

Region: chr18:25530930..25757445 View in gBrowse