ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	NRXN1
Symbol Alias	KIAA0578, Hs.22998
Approved Name	neurexin 1
Location	2p16.3
Position	chr2:50145643-51259674, -
External Links	HGNC: 8008 Entrez Gene: 9378 Ensembl: ENSG00000179915 UCSC: uc002rxe.3
No. of Studies	1 (significant: 0; non-significant: 1; trend: 0)
Source	Literature-origin; Mapped by LD-proxy; Mapped by literature SNP

Gene related studies (count: 1)

Reference	Statistical Values/Author Comments	Result of Statistical Analysis
Neale BM, 2010 (b)	No significant or Trend associated SNP was mapped in this gene.	Non-significant

Gene related SNPs (count: 3)

Literature-origin SNPs (count: 1)

rs_ID	Location	Functional Annotation	No. of Studies (significant/non-significant/trend)
rs17495366	Chr2:50268616(Fwd)	intron_variant	1(0/1/0)

LD-proxies (count: 2)

rs_ID	Location	Functional Annotation
rs1369296	Chr2:50232325(Fwd)	intron_variant
rs1363051	Chr2:50279475(Fwd)	intron_variant

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 52)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 52)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0001525	angiogenesis	Biological Process		35
GO:0005102	receptor binding	Molecular Function		61
GO:0004872	receptor activity	Molecular Function	TAS[1621094]	36
GO:0005515	protein binding	Molecular Function	IPI[11152476]	910
GO:0005246	calcium channel regulator activity	Molecular Function		10
GO:0005887	integral to plasma membrane	Cellular Component	TAS[1621094]	220
GO:0005886	plasma membrane	Cellular Component		772
GO:0007157	heterophilic cell-cell adhesion	Biological Process		11
GO:0007155	cell adhesion	Biological Process		86
GO:0007269	neurotransmitter secretion	Biological Process		18
GO:0007158	neuron cell-cell adhesion	Biological Process	TAS[15797875]	5
GO:0007411	axon guidance	Biological Process	TAS[1621094]	65
GO:0007612	learning	Biological Process	ISS[19822762]	13
GO:0009986	cell surface	Cellular Component		70
GO:0016021	integral to membrane	Cellular Component		845
GO:0016339	calcium-dependent cell-cell adhesion	Biological Process		8
GO:0023041	neuronal signal transduction	Biological Process	TAS[15797875]	2
GO:0030054	cell junction	Cellular Component		77
GO:0030139	endocytic vesicle	Cellular Component		12
GO:0030534	adult behavior	Biological Process	ISS[19822762]	5
GO:0033130	acetylcholine receptor binding	Molecular Function		2
GO:0035176	social behavior	Biological Process	IMP[17034946]	9
GO:0042734	presynaptic membrane	Cellular Component	TAS[15797875]	15
GO:0043473	pigmentation	Biological Process	IMP[17034946]	4
GO:0044295	axonal growth cone	Cellular Component		3
GO:0045184	establishment of protein localization	Biological Process		4
GO:0046872	metal ion binding	Molecular Function		170
GO:0051965	positive regulation of synapse assembly	Biological Process		4
GO:0050885	neuromuscular process controlling balance	Biological Process	ISS[19822762]	8
GO:0050839	cell adhesion molecule binding	Molecular Function		9
GO:0048306	calcium-dependent protein binding	Molecular Function		5
GO:0071625	vocalization behavior	Biological Process	IMP[19896112]	2
GO:0060325	face morphogenesis	Biological Process	IMP[17034946]	5
GO:0060134	prepulse inhibition	Biological Process	ISS[19822762]	10
GO:0051968	positive regulation of synaptic transmission, glutamatergic	Biological Process		8
GO:0097104	postsynaptic membrane assembly	Biological Process		3
GO:0097091	synaptic vesicle clustering	Biological Process		2
GO:0090129	positive regulation of synapse maturation	Biological Process		2
GO:0090004	positive regulation of establishment of protein localization to plasma membrane	Biological Process		3
GO:0097114	N-methyl-D-aspartate receptor clustering	Biological Process		2
GO:0097112	gamma-aminobutyric acid receptor clustering	Biological Process		1
GO:0097109	neuroligin family protein binding	Molecular Function		1
GO:0097105	presynaptic membrane assembly	Biological Process		3
GO:0097118	neuroligin clustering	Biological Process		2
GO:0097119	postsynaptic density protein 95 clustering	Biological Process		3
GO:0097116	gephyrin clustering	Biological Process		2
GO:0097117	guanylate kinase-associated protein clustering	Biological Process		1
GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	Biological Process		6
GO:2000463	positive regulation of excitatory postsynaptic membrane potential	Biological Process		2
GO:0097120	receptor localization to synapse	Biological Process		3
GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity	Biological Process		3
GO:2000821	regulation of grooming behavior	Biological Process		1

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04514	Cell adhesion molecules (CAMs)	20	Cell adhesion molecules are (glyco)proteins expressed on the...... Cell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes. More...

Genes shared at least 5 GO terms with NRXN1 (count: 41)

Gene Symbol	Pathway Count	Pathway List
NLGN1	21	receptor activity; integral to plasma membrane; heterophilic cell-cell adhesion; neuron cell-cell adhesion; cell surface; calcium-dependent cell-cell adhesion; neuronal signal transduction; cell junction; establishment of protein localization; positive regulation of synapse assembly; cell adhesion molecule binding; positive regulation of synaptic transmission, glutamatergic; postsynaptic membrane assembly; synaptic vesicle clustering; N-methyl-D-aspartate receptor clustering; presynaptic membrane assembly; postsynaptic density protein 95 clustering; regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity; positive regulation of excitatory postsynaptic membrane potential; receptor localization to synapse; regulation of N-methyl-D-aspartate selective glutamate receptor activity;
NRXN2	10	calcium channel regulator activity; cell adhesion; neurotransmitter secretion; integral to membrane; metal ion binding; cell adhesion molecule binding; postsynaptic membrane assembly; neuroligin clustering; postsynaptic density protein 95 clustering; gephyrin clustering;
SEMA4D	7	receptor binding; receptor activity; protein binding; integral to plasma membrane; plasma membrane; cell adhesion; axon guidance;
TNR	7	receptor binding; cell adhesion; neuron cell-cell adhesion; axon guidance; cell surface; neuromuscular process controlling balance; positive regulation of synaptic transmission, glutamatergic;
DRD3	7	protein binding; integral to plasma membrane; plasma membrane; learning; endocytic vesicle; social behavior; prepulse inhibition;
SYT1	7	protein binding; plasma membrane; neurotransmitter secretion; integral to membrane; cell junction; presynaptic membrane; calcium-dependent protein binding;
ADAM8	6	angiogenesis; protein binding; integral to plasma membrane; plasma membrane; cell surface; cell adhesion molecule binding;
CADM1	6	receptor binding; protein binding; plasma membrane; heterophilic cell-cell adhesion; integral to membrane; cell adhesion molecule binding;
PTPRD	6	receptor binding; protein binding; integral to plasma membrane; heterophilic cell-cell adhesion; cell adhesion molecule binding; presynaptic membrane assembly;
SLC6A3	6	receptor binding; protein binding; integral to plasma membrane; plasma membrane; integral to membrane; prepulse inhibition;
ACHE	6	protein binding; plasma membrane; cell adhesion; cell surface; cell junction; presynaptic membrane;
ADORA2A	6	protein binding; integral to plasma membrane; plasma membrane; presynaptic membrane; prepulse inhibition; positive regulation of synaptic transmission, glutamatergic;
DRD2	6	protein binding; integral to plasma membrane; plasma membrane; endocytic vesicle; pigmentation; prepulse inhibition;
GRIN2A	6	protein binding; integral to plasma membrane; plasma membrane; cell surface; cell junction; presynaptic membrane;
GRIN2B	6	protein binding; integral to plasma membrane; plasma membrane; learning; cell surface; cell junction;
ITGA2	6	protein binding; plasma membrane; cell adhesion; axon guidance; cell surface; metal ion binding;
PVRL1	6	protein binding; plasma membrane; heterophilic cell-cell adhesion; cell adhesion; integral to membrane; cell adhesion molecule binding;
STX1A	6	protein binding; plasma membrane; neurotransmitter secretion; integral to membrane; cell junction; calcium-dependent protein binding;
GRM7	6	calcium channel regulator activity; integral to plasma membrane; plasma membrane; integral to membrane; adult behavior; presynaptic membrane;
SLC6A1	6	integral to plasma membrane; plasma membrane; neurotransmitter secretion; learning; cell surface; integral to membrane;
PRKD1	5	angiogenesis; protein binding; integral to plasma membrane; plasma membrane; metal ion binding;
CNTNAP2	5	receptor binding; cell adhesion; cell surface; integral to membrane; vocalization behavior;
TIGIT	5	receptor binding; protein binding; plasma membrane; cell surface; integral to membrane;
HTR3A	5	receptor activity; integral to plasma membrane; plasma membrane; integral to membrane; cell junction;
ADAM17	5	protein binding; integral to plasma membrane; plasma membrane; cell adhesion; cell surface;
ANK3	5	protein binding; plasma membrane; axon guidance; cell surface; establishment of protein localization;
CACNA1C	5	protein binding; plasma membrane; axon guidance; integral to membrane; metal ion binding;
DRD1	5	protein binding; integral to plasma membrane; plasma membrane; prepulse inhibition; positive regulation of synaptic transmission, glutamatergic;
ENPP1	5	protein binding; plasma membrane; cell surface; integral to membrane; metal ion binding;
GHR	5	protein binding; integral to plasma membrane; plasma membrane; cell surface; integral to membrane;
LPAR1	5	protein binding; integral to plasma membrane; plasma membrane; cell surface; endocytic vesicle;
PTPRK	5	protein binding; integral to plasma membrane; cell adhesion; cell surface; integral to membrane;
SYT2	5	protein binding; plasma membrane; neurotransmitter secretion; integral to membrane; cell junction;
VAMP2	5	protein binding; integral to plasma membrane; plasma membrane; neurotransmitter secretion; cell junction;
CDH4	5	integral to plasma membrane; plasma membrane; heterophilic cell-cell adhesion; cell adhesion; axon guidance;
GRIK1	5	integral to plasma membrane; plasma membrane; cell junction; adult behavior; presynaptic membrane;
OXTR	5	integral to plasma membrane; plasma membrane; social behavior; positive regulation of synapse assembly; positive regulation of synaptic transmission, glutamatergic;
CDH2	5	plasma membrane; heterophilic cell-cell adhesion; cell adhesion; integral to membrane; calcium-dependent cell-cell adhesion;
ITGAL	5	plasma membrane; heterophilic cell-cell adhesion; cell adhesion; metal ion binding; cell adhesion molecule binding;
NCAM1	5	plasma membrane; cell adhesion; axon guidance; cell surface; integral to membrane;
SNPH	5	plasma membrane; neurotransmitter secretion; integral to membrane; cell junction; presynaptic membrane;

Genes shared at least 2 KEGG pathways with NRXN1 (count: 0)

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Region: chr2:50145643..51259674 View in gBrowse