ADHDgene Database

Gene Report

Basic Info

Approved Symbol	CDH4
Approved Name	cadherin 4, type 1, R-cadherin (retinal)
Name Alias	R-Cadherin
Location	20q13.3
Position	chr20:59827559-60512299, +
External Links	HGNC: 1763 Entrez Gene: 1002 Ensembl: ENSG00000179242 UCSC: uc002ybn.1
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by CNV

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 1)

ID	Location	Size	Band	Type	Inheritance
CNV_Elia[2010]_211	chr20:59555390-59592324 (NCBI Build 35 (hg17))	36935	20q13.33	Deletion (hemizygous)	Maternal

Gene related other variant (count: 0)

Gene related regions (count: 0)

Gene related GO terms (count: 11)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0007155	cell adhesion	Biological Process	TAS[2059658]	86
GO:0007156	homophilic cell adhesion	Biological Process		27
GO:0005886	plasma membrane	Cellular Component		772
GO:0005887	integral to plasma membrane	Cellular Component		220
GO:0034329	cell junction assembly	Biological Process		13
GO:0034332	adherens junction organization	Biological Process		9
GO:0007157	heterophilic cell-cell adhesion	Biological Process		11
GO:0007411	axon guidance	Biological Process		65
GO:0045773	positive regulation of axon extension	Biological Process		7
GO:0045216	cell-cell junction organization	Biological Process		10
GO:0005509	calcium ion binding	Molecular Function		124

Gene related KEGG pathways (count: 1)

ID	Name	No. of Genes in ADHDgene	Brief Description
hsa04514	Cell adhesion molecules (CAMs)	20	Cell adhesion molecules are (glyco)proteins expressed on the...... Cell adhesion molecules are (glyco)proteins expressed on the cell surface and play a critical role in a wide array of biologic processes that include hemostasis, the immune response, inflammation, embryogenesis, and development of neuronal tissue. There are four main groups: the integrin family, the immunoglobulin superfamily, selectins, and cadherins. Membrane proteins that mediate immune cell–cell interactions fall into different categories, namely those involved in antigen recognition, costimulation and cellular adhesion. Furthermore cell-cell adhesions are important for brain morphology and highly coordinated brain functions such as memory and learning. During early development of the nervous system, neurons elongate their axons towards their targets and establish and maintain synapses through formation of cell-cell adhesions. Cell-cell adhesions also underpin axon-axon contacts and link neurons with supporting schwann cells and oligodendrocytes. More...

Genes shared at least 5 GO terms with CDH4 (count: 9)

Gene Symbol	Pathway Count	Pathway List
CDH2	8	cell adhesion; homophilic cell adhesion; plasma membrane; cell junction assembly; adherens junction organization; heterophilic cell-cell adhesion; cell-cell junction organization; calcium ion binding;
CDH15	7	cell adhesion; homophilic cell adhesion; plasma membrane; cell junction assembly; adherens junction organization; cell-cell junction organization; calcium ion binding;
CDH6	7	cell adhesion; homophilic cell adhesion; plasma membrane; cell junction assembly; adherens junction organization; cell-cell junction organization; calcium ion binding;
PVRL1	7	cell adhesion; homophilic cell adhesion; plasma membrane; cell junction assembly; adherens junction organization; heterophilic cell-cell adhesion; cell-cell junction organization;
CADM1	6	homophilic cell adhesion; plasma membrane; cell junction assembly; adherens junction organization; heterophilic cell-cell adhesion; cell-cell junction organization;
CDH12	6	homophilic cell adhesion; plasma membrane; cell junction assembly; adherens junction organization; cell-cell junction organization; calcium ion binding;
CDH13	6	homophilic cell adhesion; plasma membrane; cell junction assembly; adherens junction organization; cell-cell junction organization; calcium ion binding;
CTNND1	5	cell adhesion; plasma membrane; cell junction assembly; adherens junction organization; cell-cell junction organization;
NRXN1	5	cell adhesion; plasma membrane; integral to plasma membrane; heterophilic cell-cell adhesion; axon guidance;

Genes shared at least 2 KEGG pathways with CDH4 (count: 0)

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Region: chr20:59827559..60512299 View in gBrowse