ADHDgene Database

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Large-scale studies

Data Summary

Published Variant
- SNP: 1391
- CNV: 398
- Others: 173
Published Gene: 359
Published Region: 128
Pathway by PBA: 8
Study: 361

Detail ...

Gene Report

Basic Info

Approved Symbol	IRF8
Previous Symbol	ICSBP1
Symbol Alias	IRF-8, ICSBP
Approved Name	interferon regulatory factor 8
Previous Name	interferon consensus sequence binding protein 1
Location	16q24.1
Position	chr16:85932409-85956212, +
External Links	HGNC: 5358 Entrez Gene: 3394 Ensembl: ENSG00000140968 UCSC: uc002fjh.2
No. of Studies	0 (significant: 0; non-significant: 0; trend: 0)
Source	Mapped by significant region

Gene related studies (count: 0)

Gene related SNPs (count: 0)

Gene related CNVs (count: 0)

Gene related other variant (count: 0)

Gene related regions (count: 1)

Region Name	Position	No. of Studies (significant/non-significant/trend)
16q23.1-24.3	chr16:74100000-90354753	1 (1/0/0)

Gene related GO terms (count: 19)

GO terms by PBA (with statistical significance of FDR<0.05) (count: 0)

GO terms by database search (count: 19)

ID	Name	Type	Evidence[PMID]	No. of Genes in ADHDgene
GO:0071222	cellular response to lipopolysaccharide	Biological Process		13
GO:0060337	type I interferon-mediated signaling pathway	Biological Process		5
GO:0060333	interferon-gamma-mediated signaling pathway	Biological Process		8
GO:0045893	positive regulation of transcription, DNA-dependent	Biological Process		80
GO:0032729	positive regulation of interferon-gamma production	Biological Process		9
GO:0030099	myeloid cell differentiation	Biological Process		5
GO:0019221	cytokine-mediated signaling pathway	Biological Process		28
GO:0006955	immune response	Biological Process	TAS[8861914]	45
GO:0044130	negative regulation of growth of symbiont in host	Biological Process		4
GO:0042832	defense response to protozoan	Biological Process		5
GO:0042742	defense response to bacterium	Biological Process		11
GO:0032735	positive regulation of interleukin-12 production	Biological Process		7
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	Biological Process	TAS[1460054]	78
GO:0000975	regulatory region DNA binding	Molecular Function		2
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity	Molecular Function	TAS[1460054]	15
GO:0005515	protein binding	Molecular Function		910
GO:0005634	nucleus	Cellular Component		770
GO:0005829	cytosol	Cellular Component		447
GO:0006909	phagocytosis	Biological Process		5

Gene related KEGG pathways (count: 0)

Genes shared at least 5 GO terms with IRF8 (count: 9)

Gene Symbol	Pathway Count	Pathway List
IRF7	8	type I interferon-mediated signaling pathway; interferon-gamma-mediated signaling pathway; positive regulation of transcription, DNA-dependent; cytokine-mediated signaling pathway; negative regulation of transcription from RNA polymerase II promoter; protein binding; nucleus; cytosol;
RELA	7	cellular response to lipopolysaccharide; positive regulation of transcription, DNA-dependent; cytokine-mediated signaling pathway; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; protein binding; nucleus; cytosol;
IRF9	7	type I interferon-mediated signaling pathway; interferon-gamma-mediated signaling pathway; cytokine-mediated signaling pathway; regulatory region DNA binding; protein binding; nucleus; cytosol;
IL12B	6	cellular response to lipopolysaccharide; positive regulation of interferon-gamma production; negative regulation of growth of symbiont in host; defense response to protozoan; positive regulation of interleukin-12 production; protein binding;
TLR4	6	cellular response to lipopolysaccharide; positive regulation of interferon-gamma production; immune response; defense response to bacterium; positive regulation of interleukin-12 production; protein binding;
PYCARD	5	cellular response to lipopolysaccharide; positive regulation of interferon-gamma production; protein binding; nucleus; cytosol;
HNF1B	5	positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; protein binding; nucleus;
ID2	5	positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; protein binding; nucleus; cytosol;
KAT5	5	positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; protein binding; nucleus; cytosol;

Genes shared at least 2 KEGG pathways with IRF8 (count: 0)

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Region: chr16:85932409..85956212 View in gBrowse